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Osteomodulin (OMD) directly binds to type 1 collagen. OMD suppresses formation of collagen fibrils.
Osteomodulin, osteoglycin (show OGN Proteins), and asporin (show ASPN Proteins) appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.
TGF beta 1 (show TGFB1 Proteins) signaling and stimulation of osteoadherin in human pulpal fibroblasts and in early secretory and mature odontoblasts
tyrosine sulfate-rich domains of the LRR proteins fibromodulin (show FMOD Proteins) and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors
found transforming growth factor beta1 to down regulate OSAD, while bone morphogenetic protein 2 (show BMP2 Proteins) up regulates OSAD
OSAD overexpression enhanced the differentiation and maturation of osteoblasts in vitro.
May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)- integrin (By similarity).
, KSPG osteomodulin
, keratan sulfate proteoglycan osteomodulin
, osteoadherin proteoglycan