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Human Polyclonal CLDN2 Primary Antibody for DB - ABIN390022
Morita, Furuse, Fujimoto, Tsukita: Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 2 references for ABIN390022
Human Polyclonal CLDN2 Primary Antibody for EIA, IHC (p) - ABIN951548
Smith, Schacker, Reilly, Haase: A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection. in Journal of acquired immune deficiency syndromes (1999) 2010
Show all 2 references for ABIN951548
Human Polyclonal CLDN2 Primary Antibody for EIA, WB - ABIN358849
Furuse, Fujita, Hiiragi, Fujimoto, Tsukita: Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. in The Journal of cell biology 1998
Show all 2 references for ABIN358849
Human Polyclonal CLDN2 Primary Antibody for EIA, WB - ABIN951547
Kojima, Ishida, Takikita-Suzuki, Hotta, Katsura, Nagata, Enoki, Kato, Okabe: Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinoma. in Oncology reports 2010
Show all 2 references for ABIN951547
Cow (Bovine) Polyclonal CLDN2 Primary Antibody for WB - ABIN2775603
Escaffit, Boudreau, Beaulieu: Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. in Journal of cellular physiology 2005
Data show that alterations in myosin light chain kinase (show MYLK Antibodies) activity, claudin-15 (show CLDN15 Antibodies) and claudin-2 expression are associated with gluten-induced symptomatology and intestinal permeability changes in diarrhea-predominant irritable bowel syndrome (IBS-D).
hypotonic stress induces dephosphorylation, clathrin-dependent endocytosis, and degradation of claudin-1 (show CLDN7 Antibodies) and -2 in lysosomes, resulting in disruption of the TJ barrier in renal tubular epithelial cells.
The claudin-2 expression increased in tumor necrosis factor alpha (TNF-alpha (show TNF Antibodies)) Treated Caco-2 cell monolayers.
We conclude that Claudin-2 expression is significantly associated with bile acid receptors VDR (show CYP27B1 Antibodies) and TGR5 (show GPBAR1 Antibodies) expression. Our studies identify a novel role of a tight junction protein (show OCLN Antibodies) in the development and progression of esophageal mucosal metaplasia, dysplasia and carcinoma.
The authors conclude that claudin-2 forms gated paracellular channels.
Genetic variants in CLDN2 and MORC4 (show MORC4 Antibodies) genes were associated with chronic pancreatitis in Indian patients.
The current study reveals an important and novel mechanism for VDR (show CYP27B1 Antibodies) by regulation of epithelial barriers.
Quercetin decreases claudin-2 expression mediated by up-regulation of miR-16 (show GDE1 Antibodies) expression and instability of claudin-2 mRNA in lung adenocarcinoma cells.
Pan (show SUPT6H Antibodies)-inhibition of SFK signaling pathways elevated Claudin-2 expression levels in breast cancer cells. Loss of Yes or Fyn (show FYN Antibodies) induces Claudin-2 expression; whereas, diminished Lyn (show LYN Antibodies) levels impairs Claudin-2 expression in breast cancer cells.
PKCiota binds to Rab14 (show RAB14 Antibodies) and that PKCiota requires Rab14 (show RAB14 Antibodies) for its correct distribution in cells. As with Rab14 (show RAB14 Antibodies), PKCiota protects claudin-2 from lysosomal degradation and, in consequence, modulates epithelial barrier.
findings reveal a critical albeit complex role of claudin-2 in intestinal homeostasis by regulating epithelial permeability, inflammation and proliferation
Based on studies of Cldn2(-/-) mice, claudin 2 regulates paracellular ion and water flow required for proper regulation of bile composition and flow.
IL-6 (show IL6 Antibodies) modulation of intestinal TJ permeability was regulated by JNK (show MAPK8 Antibodies) activation of AP-1 (show JUN Antibodies) and AP-1 (show JUN Antibodies) activation of claudin-2 gene
this study set out to map out all the pore-lining residues of claudin-2 by comprehensive cysteine-scanning mutagenesis of the entire first extracellular loop (ECL1).
The capacity of non-AQP1 (show AQP1 Antibodies)-dependent transcellular proximal fluid reabsorption (PFR) is sufficient to be maintained in AQP1 (show AQP1 Antibodies)- and claudin-2-doubly deficient knockout mice.
These results suggest that the ERK (show EPHB2 Antibodies) pathway positively regulates claudin-2 protein expression and claudin-2 is involved in lowering TER (show TECR Antibodies) in CMT93-II cells.
Claudin-2 assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK (show MYLK Antibodies) in colon inflammation.
cingulin (show CGN Antibodies) is dispensable for the structure and barrier function of tight junctions, and is embedded in signaling networks that control the expression of claudin-2.
Together these data are consistent with phosphorylation at S208 playing a major role in the retention of claudin-2 at the plasma membrane
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.
, integral membrane protein claudin-2