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Study conclude that CART is a regulator of glucose homeostasis and could play an important role in the pathophysiology of type 2 diabetes. Based on the ability of CART to increase insulin (show INS ELISA Kits) secretion and reduce glucagon (show GCG ELISA Kits) secretion, CART-based agents could be a therapeutic modality in type 2 diabetes.
In samples from patients undergoing IVF (show SCN5A ELISA Kits), there is a significant positive correlation between patient BMI, CART mRNA expression in granulosa cells, and CART peptide levels in follicular fluid.
Colocalization experiments provided evidence for the presence of cocaine- and amphetamine-regulated transcript (show CARTPT ELISA Kits) (CART) in KP-immunoreactive (IR) and perikarya and in KP-IR and NKB (show TAC3 ELISA Kits)-IR axon varicosities.
In schizophrenia patients on clozapine monotherapy, CART levels did not correlate with age, weight, BMI, abdominal, waist and hip circumferences, WHR, blood pressure, clozapine dose or treatment duration, body composition, or markers of insulin (show INS ELISA Kits) resistance
Family-based association study failed to observe a statistically significant association for any of the genotyped SNPs in the CARTPT (show CARTPT ELISA Kits) gene and attention-deficit hyperactivity disorder.
Ischemia insult triggered by oxygen-glucose deprivation (OGD (show FGFR1 ELISA Kits)) enhances NRSF (show REST ELISA Kits) mRNA levels and then NRSF (show REST ELISA Kits) antagonizes the CREB (show CREB1 ELISA Kits) signaling on CART activation, leading to augmented cell death.
It was shown that cocaine- and amphetamine-regulated transcript protein (show CARTPT ELISA Kits) (CART) increases the transcriptional activity of estrogen receptor alpha (show ESR1 ELISA Kits) and that CART stimulates an autocrine/paracrine loop within tumor cells to amplify the CART signal.
This gene encodes a secreted protein which is processed by prohormone/proprotein convertases to produce smaller, biologically active peptides. Expression of the transcript for this gene is regulated by certain drugs such as cocaine, and the encoded protein is thought to be involved in the regulation of appetite and stress. Mutations in this gene are associated with susceptibility to obesity.
cocaine and amphetamine regulated transcript
, cocaine- and amphetamine-regulated transcript protein