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Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305110
Chiu, Moulds, Coffman, Rennick, Lee: Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. in Proceedings of the National Academy of Sciences of the United States of America 1988
Show all 5 Pubmed References
Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305109
Prussin, Metcalfe: Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. in Journal of immunological methods 1996
Show all 5 Pubmed References
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305111
Kitamura, Takaku, Miyajima: IL-1 up-regulates the expression of cytokine receptors on a factor-dependent human hemopoietic cell line, TF-1. in International immunology 1991
Show all 4 Pubmed References
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN803874
Tan, Li, Rajendran, Kumar, Hui, Sethi et al.: Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis ... in The Journal of pharmacology and experimental therapeutics 2010
Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN804234
Han, Kitamoto, Wang, Boisvert: Interleukin-10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1525747
Andrianjafiniony, Dupré-Aucouturier, Letexier, Couchoux, Desplanches: Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading. in American journal of physiology. Cell physiology 2010
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN620832
Leyh, Seitz, Dürselen, Schaumburger, Ignatius, Grifka, Grässel: Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. in Arthritis research & therapy 2015
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1112348
Xin, Mizukami, Urabe, Toda, Shinoda, Yoshida, Oomura, Kojima, Ichino, Klinman, Ozawa, Okuda: Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells. in Journal of virology 2006
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1878195
Fan, Ren, Zhu, Zhang, Zhu: A new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structure. in Biosensors & bioelectronics 2014
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1589641
Poli, Asperti, Ruzzenenti, Mandelli, Campostrini, Martini, Di Somma, Maccarinelli, Girelli, Naggi, Arosio: Oversulfated heparins with low anticoagulant activity are strong and fast inhibitors of hepcidin expression in vitro and in vivo. in Biochemical pharmacology 2014
In the context of the elastase model of abdominal aortic aneurysm disease, IL-6 appears a multi-faceted factor, protective upon acute injury, but negatively involved in the perpetuation of the disease process
Results demonstrate that increased tumor-associated macrophages-derived IL-6 had an amplifying effect on the i (show FAM126A Proteins)nflammation response, thereby promoting the occurrence and development of hepatocellular carcinoma (HCC).
activation of beta2-AR accelerated hepatocyte proliferation and improved recellularized liver function by mediating the IL-6/Stat 3 (show STAT3 Proteins) signalling pathway, indicating that nervous system regulation may be an essential component contributing to the complexity of recellularized liver in tissue engineering
Taken together, we indicated that anti-IL-6 and anti-TNF-alpha (show TNF Proteins) therapy prevent intestinal permeability induced by intestinal inflammation
However, the mechanism that induces release of IL-6 from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway.
Following vasectomy, IL1alpha (show IL1A Proteins), IL1beta (show IL1B Proteins), IL1ra (show IL1RN Proteins), IL10 (show IL10 Proteins), and TNF-alpha (show TNF Proteins) may mediate immune reaction in whole epididymis, whereas IL6 and TGF-beta1 (show TGFB1 Proteins) may mediate regionally different immune response primarily in the lower part of epididymis.
IL-6 induces prostate oncogenesis through amplifying local inflammation.
IFN-gamma (show IFNG Proteins)/TNFalpha (show TNF Proteins) activate the JAKs/STAT3 (show STAT3 Proteins) signaling pathway in an IL-6-independent manner in skeletal muscle fibers.
interactions between TNF-alpha (show TNF Proteins) and IL-6 exacerbate oxidative stress and reduce phosphorylation of eNOS (show NOS3 Proteins), thereby contributing to coronary endothelial dysfunction in T2D mice.
Data show that lack of B cell-derived IL-6 abrogates spontaneous germinal centers (GCs (show UGCG Proteins)) formation in systemic lupus erythematosus (SLE).
IL-6 and TNF-alpha (show TNF Proteins) CSF (show CSF2 Proteins) levels are elevated in subarachnoid hemorrhage (SAH (show ACSM3 Proteins)) patients and may participate in SAH (show ACSM3 Proteins) development.
Identify Kaposi sarcoma virus miR (show MLXIP Proteins)-K12 (show KRT12 Proteins)-1 as an oncogene (show RAB1A Proteins) which activates NF-kappaB (show NFKB1 Proteins)/IL-6/STAT3 (show STAT3 Proteins) signaling pathway, promoting tumorigenesis.
Serum IL-6 and IL-10 (show IL10 Proteins) admission levels for patients with Takotsubo cardiomyopathy are associated with higher risk of adverse events during follow-up
Interleukin-6 as possible early marker of stress response after femoral fracture.
Results showed that serum IL-6 levels were significantly higher in patients with hepatocellular carcinoma (HCC (show FAM126A Proteins)) and demonstrate that increased tumor-associated macrophages -derived IL-6 had an amplifying effect on the inflammation response, thereby promoting the occurrence and development of HCC (show FAM126A Proteins).
Data show that secretion of IL-6 induced by loss of HIC1 (show HIC1 Proteins) activated STAT3 (show STAT3 Proteins) through IL-6/JAK (show JAK3 Proteins) pathway and was associated with NSCLC progression.
YY1 (show YY1 Proteins) was over-expressed in RA which can bind to the promotor of IL-6 to introduce IL-6 expression, contributing to the inflammation of RA via stimulation of Th17 differentiation.
study demonstrates enhanced T cell responses to IL-6 in T1D due, in part, to an increase in IL-6R surface expression. Dysregulated IL-6 responsiveness may contribute to diabetes through multiple mechanisms including altered T cell trafficking
Levels of serum pentraxin 3 (show PTX3 Proteins), IL-6, fetuin A (show AHSG Proteins) and insulin (show INS Proteins) in patients with rheumatoid arthritis.
This result suggests that the IL-6 -174 polymorphism is a putative independent risk indicator for new cardiovascular events among patients with coronary heart disease.
STA3 (show ARHGEF3 Proteins) facilitates TLR4 (show TLR4 Proteins)-dependent IL-6 and IL-8 (show IL8 Proteins) production via IL-6 receptor-positive feedback in endometrial cells.
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.
Testicular IL-1 alpha (show IL1A Proteins) and IL-1 beta (show IL1B Proteins) concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Proteins) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha (show TNF Proteins), iNOS (show NOS2 Proteins), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Proteins) was unaffected.[IL-6, IL-12 (show IL12A Proteins)]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Proteins) and IL-6/sIL-6R in causing proteoglycan (show Vcan Proteins) degradation in human and bovine cartilage.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta (show IL1B Proteins) and IL-6 in rabbit cornea cells.
we showed that IL-6 did not directly promote the proliferation of theca interna cells.
Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1 (show HIF1A Proteins)-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Proteins), IL-10 (show IL10 Proteins), and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (show STAT3 Proteins) (signal transducer/activator of transcription (show STAT1 Proteins) 3) signaling pathway (including up-regulation of STAT3 (show STAT3 Proteins) expression/phosphorylation).
LIF (show LIF Proteins) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
interleukin-6, endothelin ET-1 (show EDN1 Proteins), and apoptotic Bak (show BAK1 Proteins) and Bcl-XL (show BCL2L1 Proteins) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP, ICAM-1 (show ICAM1 Proteins), TNF-alpha (show TNF Proteins), VCAM-1 (show VCAM1 Proteins) and IL-6, quickly and reliably signaled adverse interactions.
IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.
These results suggest that TNF-alpha (show TNF Proteins) and IL-10 (show IL10 Proteins), but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (show WNT2 Proteins) signaling pathway transactivator beta-catenin (show CTNNB1 Proteins), induced expression of inhibitors of the Wnt (show WNT2 Proteins) pathway, and increased expression of GDF-5 (show GDF5 Proteins).
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (show ADORA2B Proteins) activation and that this effect can be modulated by A2AAR (show ADORA2A Proteins)
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (show IL10 Proteins) alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (show IL10 Proteins) and TNF-alpha (show TNF Proteins), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (show KRT12 Proteins)), are potent inducers of IL-1beta (show IL1B Proteins) and IL-6 gene expression and were equal to, or more potent than, crude LPS (show IRF6 Proteins).
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
B-cell hybridoma growth factor
, interleukin HP-1
, Interleukin 6 (interferon, beta 2)
, B-cell differentiation factor
, B-cell stimulatory factor 2
, CTL differentiation factor
, hybridoma growth factor
, interferon beta-2
, interleukin BSF-2
, interleukin-6 protein