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Browse our Interleukin 6 Proteins (IL6)

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Interleukin 6 Proteins (IL6)
On are 218 Interleukin 6 (IL6) Proteins from 29 different suppliers available. Additionally we are shipping Interleukin 6 Antibodies (887) and Interleukin 6 Kits (344) and many more products for this protein. A total of 1475 Interleukin 6 products are currently listed.
BSF2, CHIL-6, HGF, HSF, IFNB2, IL-6, il6, ILg6
list all proteins Gene Name GeneID UniProt
IL6 16193 P08505
Rat IL6 IL6 24498 P20607
IL6 3569 P05231

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Interleukin 6 Proteins (IL6) by Origin

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Top referenced Interleukin 6 Proteins

  1. Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2667541 : Murakami, Hibi, Nakagawa, Nakagawa, Yasukawa, Yamanishi, Taga, Kishimoto: IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. in Science (New York, N.Y.) 1993 (PubMed)
    Show all 5 references for ABIN2667541

  2. Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305109 : Chiu, Moulds, Coffman, Rennick, Lee: Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. in Proceedings of the National Academy of Sciences of the United States of America 1988 (PubMed)
    Show all 5 references for ABIN1305109

  3. Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305110 : Van Snick, Cayphas, Szikora, Renauld, Van Roost, Boon, Simpson: cDNA cloning of murine interleukin-HP1: homology with human interleukin 6. in European journal of immunology 1988 (PubMed)
    Show all 5 references for ABIN1305110

  4. Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305111 : Kitamura, Takaku, Miyajima: IL-1 up-regulates the expression of cytokine receptors on a factor-dependent human hemopoietic cell line, TF-1. in International immunology 1991 (PubMed)
    Show all 4 references for ABIN1305111

  5. Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2002764 : Kishimoto, Akira, Narazaki, Taga: Interleukin-6 family of cytokines and gp130. in Blood 1995 (PubMed)
    Show all 4 references for ABIN2002764

  6. Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2007389 : Heinrich, Behrmann, Müller-Newen, Schaper, Graeve: Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. in The Biochemical journal 1998 (PubMed)
    Show all 3 references for ABIN2007389

  7. Rhesus Monkey Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2009972 : Chung, Seo, Hur, Kim, Kim, Jung, Kim, Park, Shin: Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. in Journal of human genetics 2003 (PubMed)
    Show all 3 references for ABIN2009972

  8. Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1878195 : Fan, Ren, Zhu, Zhang, Zhu: A new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structure. in Biosensors & bioelectronics 2014 (PubMed)

More Proteins for Interleukin 6 Interaction Partners

Mouse (Murine) Interleukin 6 (IL6) interaction partners

  1. MKP-5 (show DUSP10 Proteins)-mediated regulation of JNK (show MAPK8 Proteins) negatively regulates phosphorylation of GRAB, which subsequently controls secretion of IL-6

  2. This study indicates that the ANG II (show AGT Proteins) effects are, in part, mediated or triggered by Gal-3 (show LGALS3 Proteins) together with the related intercellular signaling (ICAM-1 (show ICAM1 Proteins) and IL-6), leading to cardiac inflammation and fibrosis.

  3. While ambient IL-6 was sufficient to suppress the induction of expression of the transcription factor Foxp3 (show FOXP3 Proteins) in T cells, trans-presentation of IL-6 by DC-bound IL-6Ralpha (show IL6R Proteins) (called 'IL-6 cluster signaling' here) was needed to prevent premature induction of interferon-gamma (IFN-gamma (show IFNG Proteins)) expression in T cells and to generate pathogenic TH17 cells in vivo.

  4. Skeletal muscle IL-6 seems to regulate whole body substrate utilization in the fed, but not fasted, state and influence skeletal muscle pyruvate dehydrogenase-E1alpha (show PDHA1 Proteins) activity in a circadian manner. However, skeletal muscle IL-6 is not required for maintaining metabolic flexibility in response to fasting.

  5. tumor-induced IL-6 impairs the ketogenic response to reduced caloric intake, resulting in a systemic metabolic stress response that blocks anti-cancer immunotherapy.

  6. Furthermore, IL-6 MKO mice had higher hepatic pyruvate dehydrogenase (PDH (show PDP Proteins))(Ser232) and PDH (show PDP Proteins)(Ser300) phosphorylation than control mice at rest. In conclusion, hepatic gluconeogenic capacity in mice is increased during prolonged exercise independent of muscle IL-6. Furthermore, Skeletal muscle IL-6 influences hepatic substrate regulation at rest and hepatic glucose metabolism during prolonged exercise, seemingly independent

  7. Brd3 (show BRD3 Proteins) knockout significantly decreased the recruitment of acetylase CBP (show CREBBP Proteins) to IL6 gene promoter, and the acetylation level of histone3 within IL6 gene promoter was repressed.

  8. The production of inflammatory mediators of IL-6 and COX-2 was also significantly attenuated when treated with 1. It may be attributed to inhibiting NFkappaB signaling. Moreover, this polyphenol suppressed p-STAT3 (show STAT3 Proteins) production as well as its downstream proteins response for apoptosis, such as Bcl-2 (show BCL2 Proteins) and Bax (show BAX Proteins). In summary, the study not only afforded our understanding involved in colitis, but also provided the possible thera...

  9. Taken together, these data show that, in adipose tissues, IL-17A (show IL17A Proteins) contributes to exacerbating insulin (show INS Proteins) resistance-enhancing IL-6 production and promotes the infiltration of Th17 cells in cooperation with TNFalpha (show TNF Proteins); these findings represent a novel hypothesis for the association between IL-17A (show IL17A Proteins)-producing cells and type 2 diabetes.

  10. beta2-Adrenergic receptor (show ADRB2 Proteins) signaling upregulated IL-6 mRNA expression between 10- and 60-fold in mouse retinal microglia, pericytes, RPE (show RPE Proteins), and choroidal endothelial cells in culture.

Human Interleukin 6 (IL6) interaction partners

  1. data demonstrated that Tipalpha may accelerate tumor aggressiveness in gastric cancer by promoting EMT (show ITK Proteins) through activation of IL-6/STAT3 (show STAT3 Proteins) pathway

  2. Elevated serum Il-6 levels are associated with disease activity and the development of cardiopulmonary manifestations in systemic sclerosis patients.

  3. tumor-induced IL-6 impairs the ketogenic response to reduced caloric intake, resulting in a systemic metabolic stress response that blocks anti-cancer immunotherapy.

  4. this study shows that IL-6 may not be a marker for the selection of patients with sinus arrhythmia or coronary artery disease

  5. Inflammatory factor IL-6 may participate in the pathogenesis of atherosclerosis by increasing endothelial lipase (EL (show LIPG Proteins)) expression and the proliferation of endothelial cells via the p38 MAPK (show MAPK14 Proteins) and NF-kappaB (show NFKB1 Proteins) signaling pathways.

  6. our results also revealed a significant difference in the genotype/allele frequencies of the rs1800624 and rs1800625 polymorphisms between the sepsis and severe sepsis subtypes, the rs1800624 TT or rs1800625 TT genotype carriers exhibited a significant increase in RAGE (show AGER Proteins) mRNA, sRAGE, TNF-a (show TNF Proteins) and IL-6 expression compared with the rs1800624 AT/AA or rs1800625 CT/CC carriers in sepsis patients

  7. IL-6 trans-signaling and PTX3 (show PITX3 Proteins) amplification at the site of inflammation could have a role in pathophysiological mechanisms of Peyronie's disease.

  8. co-culturing with osteosarcoma cancer stem cells with mesenchymal stromal cells stimulated the migratory capacity of osteosarcoma via TGFbeta1 (show TGFB1 Proteins) and IL-6 secretion.

  9. Results show no association of TNF-alpha (show TNF Proteins) (rs1800629) and IL-6 (rs1800795) polymorphisms with chemotherapy induced cognitive impairment.

  10. MAOA (show MAOA Proteins) provides tumor cell growth advantages in the bone microenvironment by stimulating interleukin-6 (IL6) release from osteoblasts, and triggers skeletal colonization by activating osteoclastogenesis through osteoblast production of RANKL (show TNFSF11 Proteins) and IL6.

Cow (Bovine) Interleukin 6 (IL6) interaction partners

  1. when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.

  2. The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.

  3. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

  4. Testicular IL-1 alpha (show IL1A Proteins) and IL-1 beta (show IL1B Proteins) concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Proteins) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.

  5. The results showed that the expression of TNF-alpha (show TNF Proteins), iNOS (show NOS2 Proteins), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Proteins) was unaffected.[IL-6, IL-12 (show IL12A Proteins)]

  6. results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes.

  7. Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Proteins) and IL-6/sIL-6R in causing proteoglycan (show Vcan Proteins) degradation in human and bovine cartilage.

Rabbit Interleukin 6 (IL6) interaction partners

  1. Mild heat shock increased the production of inflammatory cytokines, IL-1beta (show IL1B Proteins) and IL-6 in rabbit cornea cells.

Pig (Porcine) Interleukin 6 (IL6) interaction partners

  1. we showed that IL-6 did not directly promote the proliferation of theca interna cells.

  2. Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1 (show HIF1A Proteins)-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.

  3. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Proteins), IL-10 (show IL10 Proteins), and IL-6 in ovarian follicles are reported.

  4. Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (show STAT3 Proteins) (signal transducer/activator of transcription (show STAT1 Proteins) 3) signaling pathway (including up-regulation of STAT3 (show STAT3 Proteins) expression/phosphorylation).

  5. LIF (show LIF Proteins) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.

  6. INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.

  7. interleukin-6, endothelin ET-1 (show EDN1 Proteins), and apoptotic Bak (show BAK1 Proteins) and Bcl-XL (show BCL2L1 Proteins) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury

  8. Data show that all five molecules, BNP, ICAM-1 (show ICAM1 Proteins), TNF-alpha (show TNF Proteins), VCAM-1 (show VCAM1 Proteins) and IL-6, quickly and reliably signaled adverse interactions.

  9. IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.

  10. These results suggest that TNF-alpha (show TNF Proteins) and IL-10 (show IL10 Proteins), but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.

Goat Interleukin 6 (IL6) interaction partners

  1. Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.

Horse (Equine) Interleukin 6 (IL6) interaction partners

  1. These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.

  2. IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (show WNT2 Proteins) signaling pathway transactivator beta-catenin (show CTNNB1 Proteins), induced expression of inhibitors of the Wnt (show WNT2 Proteins) pathway, and increased expression of GDF-5 (show GDF5 Proteins).

  3. study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (show ADORA2B Proteins) activation and that this effect can be modulated by A2AAR (show ADORA2A Proteins)

  4. Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.

  5. Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.

  6. Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (show IL10 Proteins) alone, were useful diagnostic indices of sepsis in equine neonates.

  7. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (show IL10 Proteins) and TNF-alpha (show TNF Proteins), in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Rainbow Trout (Oncorhynchus mykiss) Interleukin 6 (IL6) interaction partners

  1. IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.

  2. in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout

  3. found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (show KRT12 Proteins)), are potent inducers of IL-1beta (show IL1B Proteins) and IL-6 gene expression and were equal to, or more potent than, crude LPS (show IRF6 Proteins).

Interleukin 6 (IL6) Protein Profile

Protein Summary

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.

Alternative names and synonyms associated with Interleukin 6 (IL6)

  • interleukin 6 (Il6)
  • interleukin 6 (interferon, beta 2) (IL6)
  • interleukin-6 (il-6)
  • BSF2 protein
  • CHIL-6 protein
  • HGF protein
  • HSF protein
  • IFNB2 protein
  • IL-6 protein
  • il6 protein
  • ILg6 protein

Protein level used designations for Interleukin 6 Proteins (IL6)

B-cell hybridoma growth factor , interleukin HP-1 , interleukin-6 , IL-6 , Interleukin 6 (interferon, beta 2) , B-cell differentiation factor , B-cell stimulatory factor 2 , BSF-2 , CDF , CTL differentiation factor , IFN-beta-2 , hybridoma growth factor , interferon beta-2 , interleukin BSF-2 , Anpl-IL*06-01 , interleukin-6 protein , interferon-beta-2

16193 Mus musculus
24498 Rattus norvegicus
3569 Homo sapiens
443406 Ovis aries
395337 Gallus gallus
280826 Bos taurus
403985 Canis lupus familiaris
101798321 Anas platyrhynchos
100008733 Oryctolagus cuniculus
399500 Sus scrofa
517016 Bos taurus
100860785 Capra hircus
100034196 Equus caballus
493687 Felis catus
705819 Macaca mulatta
101281783 Orcinus orca
100136689 Oncorhynchus mykiss
503562 Takifugu rubripes
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