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MRAP2b decreases the constitutive activity of the MC4R during fasting periods, driving the animal toward a positive energy balance.
MRAP2 proteins allow for developmental control of MC4R activity, with MRAP2a blocking its function and stimulating growth during larval development, whereas MRAP2b enhances responsiveness to alpha-MSH once the zebrafish begins feeding, thus increasing the capacity for regulated feeding and growth.
The common variant rs17782313 near MC4R is associated with body mass index and measures of body fatness in children aged 2-9 years.
Case Report: MC4R p.Met215del coexisting with FTO and MC1R gene variants, causes severe early onset obesity.
An SNP in the FTO (show FTO Proteins) (rs9939609) gene but not in the MC4R (rs17782313) gene was significantly associated with prepregnancy body mass index (BMI) >/=25 kg/m(2) (relative riskFTO = 2.1; 95% confidence interval [CI], 1.4-3.1). SNPs were not statistically associated with excessive gestational weight gain (GWG) or postpartum weight retention (PPWR).
genetic association studies in population of children in Chile: Data suggest that a polymorphism in the 3prime untranslated region of MC4R (rs17782313) is associated with eating behavior leading to overweight/obesity in the pediatric population studied (children 8-14 years old).
Genetic alterations in the leptin, LEPR and MC$R genes are associated with severe obesity.
FTO (show FTO Proteins) rs9939609, MC4R rs17782313, and PPARgamma (show PPARG Proteins) rs1801282 polymorphisms seem to have little effect on the incidence of metabolic malfunctions and no effect on androgen-related disorders in the examined middle-aged and elderly men.
Epigenetic alterations of the newly identified genes MC4R and HNF4a (show HNF4A Proteins) in early life might contribute to metabolic profile changes, especially increased triglyceride levels, in the cord blood of preterm infants.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R), pro-opiomelanocortin (POMC (show POMC Proteins)), apolipoprotein E (APOE (show APOE Proteins)) and agouti-related protein (AGRP (show AGRP Proteins)) with obesity in the North Indian population.
Data provide evidence that variants of MC4R and LYPLAL1 (show LYPLAL1 Proteins) modulate body fat distribution with sexual dimorphism in a Chinese population.
that the FTO rs9939609 and MC4R rs17782313 variants may be significantly associated with nocturnal but not daytime blood pressure levels and their combined effects were significant in this Chinese Han population
Atherosclerosis and Hypercholesterolemia in Mice Lacking Both the Melanocortin Type 4 Receptor and Low Density Lipoprotein Receptor (show LDLR Proteins)
results indicate that the MC4R is not required for estrogen's effects on metabolic and reproductive functions
Mc4r receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling.
Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R-SphK1 (show SPHK1 Proteins) signaling.
Our findings support the hypothesis that MC4R signaling in the pedunculopontine tegmental nucleus may involve in the modulation of midbrain dopamine systems.
These results indicate that intact CNS MC4R signaling is necessary for leptin (show LEP Proteins) to exert its chronic antidiabetic, anorexic, and cardiovascular actions.
Mc4r signaling has a protective role in minimizing glucose fluctuations due to circadian rhythms and environmental light cues, a previously undiscovered connection between circadian biology and glucose metabolism mediated through the melanocortin system.
MC4R specifically inhibited the presynaptic N-type channel subtype, and this inhibition may be important for the effects of melanocortin in the central subdivision of the amygdala
Coupling of MC4R to Kir7.1 (show KCNJ13 Proteins) may explain unusual aspects of the control of energy homeostasis by melanocortin signalling, including the gene dosage effect of MC4R and the sustained effects of AgRP (show AGRP Proteins) on food intake.
The MC4R-expressing neurons regulating feeding are SIM1 (show SIM1 Proteins)(+), located in the paraventricular hypothalamus, glutamatergic and not GABAergic, and do not express oxytocin, corticotropin-releasing hormone (show CRH Proteins), vasopressin (show AVP Proteins), or prodynorphin (show PDYN Proteins).
evaluate the association of single nucleotide polymorphisms (SNPs) in MC4R with milk production traits in water buffalo. Based on the SNP data, seven haplotypes were constructed. Three SNPs H1 (AGT (show AGT Proteins)), H2 (GAT), and H3 (GAC (show GLS Proteins)) accounted for 93.0% of the total individuals. Statistical analysis indicated that the SNP g.1104C>T was significantly associated with milk yield, protein, and fat percentage.
The MC4R gene may thus be a candidate gene for carcass traits with MC4R single nucleotide polymorphisms being potentially valuable as genetic markers for economic traits in Hanwoo.
The aim was to estimate the frequency of the SNPs in the MC4R gene and to determine if individual genotypes were associated with several economic traits.
The results suggested that -129A>G and 1,069C>G single nucleotide polymorphism of the MC4R gene may be useful as a genetic marker for carcass and meat quality traits in Qinchuan cattle.
results are suggestive that adrenal glucocorticoid production could be regulated through melanocortin 4 receptor
Single nucleotide polymorphisms in 5'-untranslated region of MC4R gene, were detected.
These results indicate that genetic selection against boar taint is possible using MC4R as a marker.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Transcriptional profiling was used to identify genes and pathways that responded to intracerebroventricular injection of MC4R agonist [Nle(4), d-Phe(7)]-alpha-melanocyte stimulating hormone (show POMC Proteins) in pigs homozygous for the missense mutation in the MC4R.
study did not find any significant associations for polymorphisms in insulin (show INS Proteins)-like grwoth factor 2, GTP Binding Protein (show RND1 Proteins) alpha Subunits, Gs and melanocortin receptor 4 genes with reproductive traits of Polish Landrace and Large White pigs
Linkage disequilibrium analysis among MC4R, LEP (show LEP Proteins) and H-FABP (show FABP3 Proteins) revealed that these genes were independent.
The c.1426G>A polymorphism affects daily gain, feed conversion ratio and ham weight in both breeds, lean cuts in the Italian Duroc and backfat thickness in the Italian Large White.
MC4R allelic variants had no effects on meat quality traits.
The effects of missense mutations of MC4R on carcass composition, growth traits and meat quality in 1191 gilts of five swine breeds are reported.
No effect of the MC4R trait nucleotides could be seen on muscle growth.
Results of associated analysis show that the polymorphism of MC4R gene was associated traits of back fat thickness (BF).
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.
melanocortin receptor 4
, melanocortin 4-receptor
, melanocortin 4 receptor
, melanocortin-4 receptor
, Melanocortin receptor 4