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Browse our anti-MTM1 (MTM1) Antibodies

Full name:
anti-Myotubularin 1 Antibodies (MTM1)
On www.antibodies-online.com are 79 Myotubularin 1 (MTM1) Antibodies from 19 different suppliers available. Additionally we are shipping MTM1 Kits (4) and MTM1 Proteins (4) and many more products for this protein. A total of 94 MTM1 products are currently listed.
Synonyms:
AF073996, CNM, mKIAA4176, Mtm, MTMX, wu:fb19c01, XLMTM, zgc:123266

Most Popular Reactivities for anti-MTM1 (MTM1) Antibodies

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anti-Human MTM1 Antibodies:

anti-Rat (Rattus) MTM1 Antibodies:

anti-Mouse (Murine) MTM1 Antibodies:

All available anti-MTM1 Antibodies

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Top referenced anti-MTM1 Antibodies

  1. Human Polyclonal MTM1 Primary Antibody for IHC (p), WB - ABIN1882103 : Herman, Kopacz, Zhao, Mills, Metzenberg, Das: Characterization of mutations in fifty North American patients with X-linked myotubular myopathy. in Human mutation 2002 (PubMed)
    Show all 6 references for ABIN1882103

  2. Human Polyclonal MTM1 Primary Antibody for EIA, WB - ABIN359029 : Biancalana, Caron, Gallati, Baas, Kress, Novelli, DApice, Lagier-Tourenne, Buj-Bello, Romero, Mandel: Characterisation of mutations in 77 patients with X-linked myotubular myopathy, including a family with a very mild phenotype. in Human genetics 2003 (PubMed)
    Show all 3 references for ABIN359029

  3. Human Polyclonal MTM1 Primary Antibody for ICC, IF - ABIN4337571 : Gupta, Hnia, Smith, Gundry, McIntire, Shimazu, Bass, Talbot, Amoasii, Goldman, Laporte, Beggs: Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafish. in PLoS genetics 2013 (PubMed)
    Show all 2 references for ABIN4337571

  4. Human Monoclonal MTM1 Primary Antibody for IHC (p), RNAi - ABIN561867 : Hedberg, Lindberg, Máthé, Moslemi, Oldfors: Myopathy in a woman and her daughter associated with a novel splice site MTM1 mutation. in Neuromuscular disorders : NMD 2012 (PubMed)

  5. Human Polyclonal MTM1 Primary Antibody for ELISA, WB - ABIN268752 : Laporte, Hu, Kretz, Mandel, Kioschis, Coy, Klauck, Poustka, Dahl: A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast. in Nature genetics 1996 (PubMed)

More Antibodies against MTM1 Interaction Partners

Zebrafish Myotubularin 1 (MTM1) interaction partners

Human Myotubularin 1 (MTM1) interaction partners

  1. Results confirm that the severe neonatal onset of myopathy in male infants is sufficient to address the direct molecular testing toward the MTM1 gene and, above all, suggest that the number of undiagnosed symptomatic female carriers is probably underestimated

  2. This study demonistrated that MTM1 mutation releated to Centronuclear myopathy.

  3. mutations in SPEG (show SPEG Antibodies) cause a centronuclear myopathy phenotype as a result of its interaction with MTM1.

  4. Mutations in specific myotubularins such as MTM1 result in myotubular myopathy and Charcot-Marie-Tooth peripheral neuropathy. (Review)

  5. Large duplications in MTM1 may account for a number of Centronuclear myopathy cases that have remained genetically unresolved.

  6. Analysis of human XLMTM patient myotubes showed that mutations that disrupt the interaction between myotubularin and MTMR12 (show MTMR12 Antibodies) proteins result in reduction of both myotubularin and MTMR12 (show MTMR12 Antibodies)

  7. data explain the basis for phenotypic variability among human patients with MTM1 p.R69C mutations and establish the Mtm1 p.R69C mouse as a valuable model for the disease, as its less severe phenotype will expand the scope of testable preclinical therapies

  8. The patients of Myopathy had a novel heterozygous splice site mutation in the myotubularin gene, MTM1 (c.867+1G>T). Analysis of MTM1 cDNA revealed that the mutation resulted in aberrant splicing with variable exon skipping.

  9. A nonsense mutation Arg486STOP was identified in exon 7 of the MTM1 gene.

  10. Myotubularin regulates Akt (show AKT1 Antibodies)-dependent survival signaling via phosphatidylinositol 3-phosphate.

Mouse (Murine) Myotubularin 1 (MTM1) interaction partners

  1. Differential muscle hypertrophy is associated with satellite cell numbers and Akt (show AKT1 Antibodies) pathway activation following activin type IIB receptor (show ACVR2B Antibodies) inhibition in Mtm1

  2. MTM1 interacts with BIN1 (show BIN1 Antibodies) in skeletal muscle.

  3. Data show that the IGF1R (show IGF1R Antibodies)/Akt (show AKT1 Antibodies) pathway is affected in phosphoinositide phosphatase myotubularin (MTM1)-deficient muscles.

  4. Deletion of the Mtm1 gene in a mature muscle reproduces the pathological hallmarks of myotubular myopathy.

  5. study reveal a direct function of MTM1 enzymatic activity in SR remodeling and a key role for PtdIns3P in promoting SR membrane curvature in skeletal muscle.

  6. aberrant mTORC1 signaling and impaired autophagy are consequences of the loss of Mtm1

  7. Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice.

  8. These studies demonstrate specific abnormalities in myogenic cell number and behavior that may relate to the progression of disease in myotubularin deficiency.

  9. data explain the basis for phenotypic variability among human patients with MTM1 p.R69C mutations and establish the Mtm1 p.R69C mouse as a valuable model for the disease, as its less severe phenotype will expand the scope of testable preclinical therapies

  10. Inhibition of activin receptor type IIB (show ACVR2B Antibodies) increases strength and lifespan in myotubularin-deficient mice.

MTM1 Antigen Profile

Antigen Summary

This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy.

Alternative names and synonyms associated with MTM1

  • myotubularin 1 (MTM1) antibody
  • myotubularin 1 (mtm1) antibody
  • myotubularin 1 (Mtm1) antibody
  • X-linked myotubular myopathy gene 1 (Mtm1) antibody
  • AF073996 antibody
  • CNM antibody
  • mKIAA4176 antibody
  • Mtm antibody
  • MTMX antibody
  • wu:fb19c01 antibody
  • XLMTM antibody
  • zgc:123266 antibody

Protein level used designations for anti-Myotubularin 1 (MTM1) Antibodies

myotubularin 1 , fb19c01 , myotubularin , myotubularin-like , X-linked myotubular myopathy gene 1

GENE ID SPECIES
422388 Gallus gallus
560881 Danio rerio
100015113 Monodelphis domestica
100069680 Equus caballus
100081312 Ornithorhynchus anatinus
100350857 Oryctolagus cuniculus
100380488 Salmo salar
100387480 Callithrix jacchus
100470283 Ailuropoda melanoleuca
100516892 Sus scrofa
548545 Xenopus (Silurana) tropicalis
703131 Macaca mulatta
4534 Homo sapiens
612385 Canis lupus familiaris
533622 Bos taurus
288762 Rattus norvegicus
734460 Xenopus laevis
100174495 Pongo abelii
17772 Mus musculus
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