You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our Myotubularin Related Protein 2 Proteins (MTMR2)

Full name:
Myotubularin Related Protein 2 Proteins (MTMR2)
On are 7 Myotubularin Related Protein 2 (MTMR2) Proteins from 3 different suppliers available. Additionally we are shipping Myotubularin Related Protein 2 Antibodies (53) and many more products for this protein. A total of 65 Myotubularin Related Protein 2 products are currently listed.
6030445P13Rik, CMT4B, CMT4B1, DKFZp459I198, MTMR2, zgc:153915
list all proteins Gene Name GeneID UniProt
MTMR2 8898 Q13614
MTMR2 77116 Q9Z2D1
Rat MTMR2 MTMR2 315422  

Show all synonyms

Myotubularin Related Protein 2 Proteins (MTMR2) by Origin

Select your origin of interest

More Proteins for Myotubularin Related Protein 2 Interaction Partners

Human Myotubularin Related Protein 2 (MTMR2) interaction partners

  1. we identified a novel mutation in MTMR2 in a family with CMT4B1 and myelin outfoldings

  2. these results reveal that MTMR2 compartmentalization and potential subsequent effects on endosome maturation and endosome signaling are dynamically regulated through MAPK (show MAPK1 Proteins)-mediated differential phosphorylation events.

  3. Mutations in LITAF (show LITAF Proteins), RAB7 (show RAB7B Proteins), LMNA (show LMNA Proteins), and MTMR2 genes are rare in Chinese Charcot-Marie-Tooth disease (CMT) patients.

  4. Novel mutations in the PRX (show PRDX6 Proteins) and the MTMR2 genes are responsible for unusual Charcot-Marie-Tooth disease phenotypes.

  5. MTMR2 phosphorylation is likely to be a critical mechanism by which MTMR2 access to its lipid substrate(s) is temporally and spatially regulated, thereby contributing to the control of downstream endosome maturation events.

  6. MTMR2 shares similar phosphatase activity and substrate specificity than its homologous proteins MTM1 (show MTM1 Proteins) and MTMR3 (show MTMR3 Proteins)

  7. REVIEW : MTMR2 belongs to the myotubularin (show MTM1 Proteins) family of phosphoinositides phosphatases

  8. Loss of MTMR2, by decreasing Schwann cells proliferation and survival, may impair the first stages of myelination of the peripheral nervous system

  9. REVIEW : MTMR2 and homologous proteins are mutated in several neuromuscular diseases

  10. A phylogenetic study revealing co-evolution of myotubularins with PI 3 (show PI3 Proteins)-kinase class III complex

Mouse (Murine) Myotubularin Related Protein 2 (MTMR2) interaction partners

  1. Mtmr2 and Mtmr13 depend upon each other to achieve wild-type levels of protein expression. Mtmr2 stabilizes Mtmr13 on membranes, indicating that the Mtmr13 pseudophosphatase is regulated by its catalytically active binding partner.

  2. data indicate that Mtmr2 and Mtmr13/Sbf2 play critical roles in the sorting and modulation of cellular signalling which are likely to be disturbed in Charcot-Marie-Tooth disease type 4B

  3. Here we provide strong evidence that Mtmr2 and Fig4 (show FIG4 Proteins) functionally interact in both Schwann cells and neurons, and we reveal for the first time a role of Mtmr2 in neurons in vivo

  4. Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1

  5. Mtmr2 forms a dimer and the C-terminal coiled-coil is responsible for homodimerization, in addition to membrane association

  6. Schwann cell-autonomous loss of Mtmr2-Dlg1 (show DLG1 Proteins) interaction dysregulates membrane homeostasis in the paranodal region, thereby producing outfolding and recurrent loops of myelin.

  7. Loss of Mtmr2 in Schwann cells, but not in motor neurons, is both sufficient and necessary to cause Charcot-Marie-Tooth type neuropaathy.

  8. Interaction of Discs large 1 (Dlg1 (show DLG4 Proteins)) with the Sec8 (show EXOC4 Proteins) exocyst component promotes membrane addition, whereas with Mtmr2, negatively regulates membrane formation.

Myotubularin Related Protein 2 (MTMR2) Protein Profile

Protein Summary

This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene.

Alternative names and synonyms associated with Myotubularin Related Protein 2 (MTMR2)

  • myotubularin related protein 2 (MTMR2)
  • myotubularin related protein 2 (Mtmr2)
  • myotubularin related protein 2 (mtmr2)
  • 6030445P13Rik protein
  • CMT4B protein
  • CMT4B1 protein
  • DKFZp459I198 protein
  • MTMR2 protein
  • zgc:153915 protein

Protein level used designations for MTMR2

myotubularin related protein 2 , myotubularin-related protein 2 , myotubularin-related protein 2-like , Myotubularin-related protein 2

100080246 Ornithorhynchus anatinus
100352381 Oryctolagus cuniculus
100473901 Ailuropoda melanoleuca
451498 Pan troglodytes
606918 Canis lupus familiaris
699703 Macaca mulatta
100174264 Pongo abelii
100404569 Callithrix jacchus
8898 Homo sapiens
77116 Mus musculus
315422 Rattus norvegicus
536810 Bos taurus
418992 Gallus gallus
100518140 Sus scrofa
30644 Danio rerio
Selected quality suppliers for Myotubularin Related Protein 2 Proteins (MTMR2)
Did you look for something else?