Browse our Integrin alpha 4 Proteins (ITGA4)

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Integrin alpha 4 Proteins (ITGA4)
On are 1 Integrin alpha 4 (ITGA4) Proteins from 1 different suppliers available. Additionally we are shipping Integrin alpha 4 Antibodies (232) and Integrin alpha 4 Kits (9) and many more products for this protein. A total of 248 Integrin alpha 4 products are currently listed.
CD49D, IA4
list all proteins Gene Name GeneID UniProt
Mouse ITGA4 ITGA4 16401 Q00651
Rat ITGA4 ITGA4 311144  
ITGA4 3676 P13612

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Integrin alpha 4 Proteins (ITGA4) by Origin

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More Proteins for Integrin alpha 4 Interaction Partners

Rhesus Monkey Integrin alpha 4 (ITGA4) interaction partners

  1. Administration of a novel recombinant antibody against alpha4beta7 gut (show GUSB Proteins)-homing integrin during acute lentiviral infection prevents mobilization of cell lineages of the innate immune system and protects the gut (show GUSB Proteins) tissues from acute lentiviral infection.

Mouse (Murine) Integrin alpha 4 (ITGA4) interaction partners

  1. Here we delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated by the integrin alpha4 and its counter-receptor VCAM-1 (show VCAM1 Proteins), respectively; expression of the latter was upregulated in obesity.

  2. uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology

  3. Macrophage tissue factor (show F3 Proteins) prothrombotic activity is regulated by integrin-alpha4/arf6 (show ARF6 Proteins) trafficking.

  4. this study shows that alpha4beta1 integrin mediates memory CD8 (show CD8A Proteins)+ T cells accumulation in salivary glands after infection with lymphocytic choriomeningitis virus

  5. The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 (show MADCAM1 Proteins) interactions as drivers of colitis by directing inflammatory monocytes into the colon.

  6. These results suggest that Tie2 (show TEK Proteins) signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1 (show VCAM1 Proteins).

  7. ITGA4 expression enhances metastasis in MYCN (show MYCN Proteins) low neuroblastoma (show ARHGEF16 Proteins).

  8. CD49d-high-expressing Th1 (show HAND1 Proteins) memory phenotype CD4 (show CD4 Proteins)+ T cells with enhanced B cell helper activity develop early in the peritoneal cavity.

  9. Data suggest that bortezomib mobilizes hematopoietic stem cells (HSPCs) by modulation of the integrin alpha4beta1 (VLA)-4/vascular cell adhesion molecule-1 (VCAM-1 (show VCAM1 Proteins)) axis.

  10. Consistent with a role of alpha4beta7 in the generation of intestinal mononuclear phagocytes, bone marrow cells from beta7(-/-) mice poorly reconstituted small intestine retinoic acid (RA)-producing CD11c (show ITGAX Proteins)(hi) dendritic cells.

Human Integrin alpha 4 (ITGA4) interaction partners

  1. sPLA2-IIA (show PLA2G2A Proteins) activates Integrin alphaVbeta3 (show ITGAV Proteins) and Integrin alpha4beta1 in an allosteric manner. (Review)

  2. Our results suggest that the analysis of alpha4beta7 integrin expression on circulating lymphocytes cannot be considered a reliable test for gastrointestinal involvement in CVID (show TNFRSF13B Proteins) patients

  3. In colon cancer samples, there was a positive correlation between the expression of integrin alpha4 and VEGF-C (show VEGFC Proteins). Integrin alpha4 and VEGF-C (show VEGFC Proteins) were significantly associated with the clinicopathological parameters (LMVD, Duke's stage, and lymph node metastasis). patients with high integrin alpha4 or VEGF-C (show VEGFC Proteins) expression had significantly shorter overall survival and tumor-free survival time.

  4. Macrophage tissue factor (show F3 Proteins) prothrombotic activity is regulated by integrin-alpha4/arf6 (show ARF6 Proteins) trafficking.

  5. gut (show GUSB Proteins)-homing alpha4beta7 CD4 (show CD4 Proteins)(+) T cells and their functional subsets were profoundly depleted during acute HIV-1 infection.

  6. Data show tht Rho kinase (show ROCK1 Proteins) (ROCK) activity was increased by inhibiting integrin alpha4 with human umbilical vein endothelial cells (HUVECs) and hypoxia.

  7. These data showed that Mycobacterium tuberculosis ESAT-6 and ESAT-6/CFP (show CFP Proteins)-10 fusion proteins could induce adhesion of macrophages to fibronectin (show FN1 Proteins) through alpha4beta1 integrin.

  8. Enhanced susceptibility of activated endocervical CD4+ T cells to HIV may be related to increased CCR5 expression by these cell subsets, but did not appear to be due to direct interaction of integrins a4b7 or a4b1 with HIV envelope.

  9. knockdown of PTTG1 (show PTTG1 Proteins) increased expression of integrin alpha 4 (ITGA4), ITGA5 (show ITGA5 Proteins), and integrin beta 1 (ITGB1 (show ITGB1 Proteins)); otherwise, RhoA (show RHOA Proteins) expression was significantly decreased

  10. Integrin alpha 2 (show ITGA2 Proteins) and alpha 4 Yxxphi motifs interact with the endocytic clathrin adaptor, AP2 complex (show AP2B1 Proteins).

Integrin alpha 4 (ITGA4) Protein Profile

Protein Summary

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.

Alternative names and synonyms associated with Integrin alpha 4 (ITGA4)

  • integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (ITGA4)
  • integrin alpha 4 (Itga4)
  • integrin, alpha 4 (Itga4)
  • integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (itga4)
  • CD49D protein
  • IA4 protein

Protein level used designations for Integrin alpha 4 Proteins (ITGA4)

integrin alpha 4 , CD49 antigen-like family member D , LPAM subunit alpha , VLA-4 receptor, alpha 4 subunit , VLA-4 subunit alpha , integrin alpha-4 , integrin alpha-IV , lymphocyte Peyer patch adhesion molecules subunit alpha , 269C wild type , antigen CD49D, alpha-4 subunit of VLA-4 receptor , integrin alpha-4 subunit , very late activation protein 4 receptor, alpha 4 subunit

470596 Pan troglodytes
704745 Macaca mulatta
16401 Mus musculus
311144 Rattus norvegicus
3676 Homo sapiens
397839 Xenopus laevis
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