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AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.
sPLA2-IIA (show PLA2G2A Proteins) activates Integrin alphaVbeta3 (show ITGAV Proteins) and Integrin alpha4beta1 in an allosteric manner. (Review)
Our results suggest that the analysis of alpha4beta7 integrin expression on circulating lymphocytes cannot be considered a reliable test for gastrointestinal involvement in CVID (show TNFRSF13B Proteins) patients
In colon cancer samples, there was a positive correlation between the expression of integrin alpha4 and VEGF-C (show VEGFC Proteins). Integrin alpha4 and VEGF-C (show VEGFC Proteins) were significantly associated with the clinicopathological parameters (LMVD, Duke's stage, and lymph node metastasis). patients with high integrin alpha4 or VEGF-C (show VEGFC Proteins) expression had significantly shorter overall survival and tumor-free survival time.
Macrophage tissue factor (show F3 Proteins) prothrombotic activity is regulated by integrin-alpha4/arf6 (show ARF6 Proteins) trafficking.
gut (show GUSB Proteins)-homing alpha4beta7 CD4 (show CD4 Proteins)(+) T cells and their functional subsets were profoundly depleted during acute HIV-1 infection.
Data show tht Rho kinase (show ROCK1 Proteins) (ROCK) activity was increased by inhibiting integrin alpha4 with human umbilical vein endothelial cells (HUVECs) and hypoxia.
These data showed that Mycobacterium tuberculosis ESAT-6 and ESAT-6/CFP (show CFP Proteins)-10 fusion proteins could induce adhesion of macrophages to fibronectin (show FN1 Proteins) through alpha4beta1 integrin.
Enhanced susceptibility of activated endocervical CD4+ T cells to HIV may be related to increased CCR5 expression by these cell subsets, but did not appear to be due to direct interaction of integrins a4b7 or a4b1 with HIV envelope.
knockdown of PTTG1 (show PTTG1 Proteins) increased expression of integrin alpha 4 (ITGA4), ITGA5 (show ITGA5 Proteins), and integrin beta 1 (ITGB1 (show ITGB1 Proteins)); otherwise, RhoA (show RHOA Proteins) expression was significantly decreased
Here we delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated by the integrin alpha4 and its counter-receptor VCAM-1 (show VCAM1 Proteins), respectively; expression of the latter was upregulated in obesity.
uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology
this study shows that alpha4beta1 integrin mediates memory CD8 (show CD8A Proteins)+ T cells accumulation in salivary glands after infection with lymphocytic choriomeningitis virus
The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 (show MADCAM1 Proteins) interactions as drivers of colitis by directing inflammatory monocytes into the colon.
These results suggest that Tie2 (show TEK Proteins) signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1 (show VCAM1 Proteins).
ITGA4 expression enhances metastasis in MYCN (show MYCN Proteins) low neuroblastoma (show ARHGEF16 Proteins).
CD49d-high-expressing Th1 (show HAND1 Proteins) memory phenotype CD4 (show CD4 Proteins)+ T cells with enhanced B cell helper activity develop early in the peritoneal cavity.
Data suggest that bortezomib mobilizes hematopoietic stem cells (HSPCs) by modulation of the integrin alpha4beta1 (VLA)-4/vascular cell adhesion molecule-1 (VCAM-1 (show VCAM1 Proteins)) axis.
Administration of a novel recombinant antibody against alpha4beta7 gut (show GUSB Proteins)-homing integrin during acute lentiviral infection prevents mobilization of cell lineages of the innate immune system and protects the gut (show GUSB Proteins) tissues from acute lentiviral infection.
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
269C wild type
, CD49 antigen-like family member D
, VLA-4 subunit alpha
, antigen CD49D, alpha-4 subunit of VLA-4 receptor
, integrin alpha 4
, integrin alpha-4
, integrin alpha-4 subunit
, integrin alpha-IV
, very late activation protein 4 receptor, alpha 4 subunit
, LPAM subunit alpha
, VLA-4 receptor, alpha 4 subunit
, lymphocyte Peyer patch adhesion molecules subunit alpha