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The family-based study showed no association between the CNTFR rs7036351, NET rs3785143 polymorphisms, and attention-deficit hyperactivity disorder.
R28E mutation in CNTF (show CNTF ELISA Kits) abrogatesIL-6 receptor-dependent but retains CNTF (show CNTF ELISA Kits) receptor-dependent signaling via glycoprotein 130/ LIFR (show LIFR ELISA Kits).
gene expression and surface expression in NK92 cells of ciliary neurotrophic factor alpha (CNTFR-alpha) and glycoprotein (gp)130 in natural killer (NK) cells, in the context of malaria, were investigated.
Data indicate that CNTFRalpha plays a role in the formation or maintenance of tumor-initiating cells in gliomas, is a marker that correlates with histological grade, may underlie treatment resistance in some cases, and is a potential therapeutic target.
expression of neurotrophin (show BDNF ELISA Kits) receptors Pan-Trk (show NTRK1 ELISA Kits), p75 neurotrophin receptor (p75 (show NGFR ELISA Kits)(NTR (show NGFR ELISA Kits)) and ciliary neurotrophic factor receptor-alpha in ulveal melanoma does not show a role in growth.
Data show that variants in CNTFR were significantly associated with a lower age at onset of the eating disorders.
interactions of CNTFR with LIFR and gp130 in vitro
C174T polymorphism in exon 9 of CNTFR is significantly associated with fat-free (show VPS51 ELISA Kits) mass in men and women, with concomitant differences in muscular strength.
Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC (show CLC ELISA Kits) and CNTFRalpha.
In liver CNTFRalpha serves as a key modulator in regulating PI3K and AMP-activated protein kinase dynamically under CNTF stimulation, resulting in the increase of glucose uptake and translocation of glucose transporter 4.
The data, along with previous work indicating no effect of muscle specific (show EIF3K ELISA Kits) ciliary neurotrophic factor (show CNTF ELISA Kits) alpha (CNTFRalpha) depletion on motor innervation, suggest that motor neuron and muscle CNTFRalpha function in concert to maintain motor neuron axons.
CNTFR expression was downregulated by androgen in the inguinoscrotal fat pad suggesting that the genitofemoral nerve may be masculinised to control gubernacular migration in the inguinoscrotal phase of testicular descent by a negative regulating mechanism in mouse embryos .
The data of this study data suggest that CNTF (show CNTF ELISA Kits) receptors may promote adult motor neuron survival.
CNTF (show CNTF ELISA Kits)-Ralpha and CNTF (show CNTF ELISA Kits) are present in the pre-and post-synaptic sites of the neuromuscular junction.
Data show that CNTF receptor alpha subunit (show POLG ELISA Kits), CNTFRalpha, signaling in leptin (show LEP ELISA Kits)-responsive neurons is not required for endogenous maintenance of energy balance.
identification of neuropoietin as a new ligand with with important implications for murine nervous system development
CNTF (show CNTF ELISA Kits)-CNTFRalpha activates the JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) pathway leading to enhanced Cx43 (show GJA1 ELISA Kits) expression and intercellular coupling
It is suggested that the loss of CNTFRalpha from axons renders RGCs unresponsive to CNTF (show CNTF ELISA Kits), thereby contributing to regenerative failure and death, while its appearance on glia may promote glial scarring.
Co-administration of ciliary neurotrophic factor (show CNTF ELISA Kits) with its soluble receptor (show IFNAR1 ELISA Kits) protects against neuronal death and enhances neurite outgrowth.
CNTF (show CNTF ELISA Kits) receptor signaling, likely by the MNs (show GYPE ELISA Kits) themselves, can play an essential role in MN survival. This role is independent of any developmental contributions CNTF (show CNTF ELISA Kits) receptor signaling makes to MN survival or function.
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
CNTF receptor subunit alpha
, ciliary neurotrophic factor receptor subunit alpha
, CNTFR alpha
, ciliary neurotrophic factor receptor alpha
, ciliary neurotrophic factor receptor subunit alpha preproprotein
, GPA receptor subunit alpha
, growth promoting activity (GPA) receptor alpha; GPARalpha
, growth-promoting activity receptor subunit alpha
, ciliary neurotrophic factor receptor
, ciliary neurotrophic factor receptor subunit alpha-like