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anti-Human FYN antibody for Biochemical Assay

Recommended FYN Antibody (supplied by: Log in to see )

Antigen
FYN Oncogene Related To SRC, FGR, YES (FYN) Antibodies
  • AI448320
  • AW552119
  • c-fyn
  • cfyn-a
  • fyn
  • im:6908851
  • p59-FYN
  • PKC
  • si:dkey-119m7.5
  • SLK
  • SYN
  • zgc:86720
  • zgc:109996
Reactivity
Human, Mouse (Murine)
184
88
37
7
7
7
2
1
1
1
1
Host
Mouse
128
64
16
Clonality
Monoclonal
Conjugate
This FYN antibody is un-conjugated
8
7
7
7
7
7
Application
Biochemical Assay (BCA)
189
112
49
25
24
18
14
12
6
4
2
2
2
1
1
Supplier
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Available images

Catalog No. ABIN2666047
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008837764 ABIN2666048 BCA Mouse IgG Log in to see FYN-59 4

Top referenced anti-FYN antibody for Biochemical Assay

Similar anti-FYN Antibodies

Application / Reactivity Human Mouse (Murine)
Western Blotting (WB) 175 Antibodies 77 Antibodies
Proximity Ligation Assay (PLA) 2 Antibodies
Immunoprecipitation (IP) 27 Antibodies 12 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 22 Antibodies 15 Antibodies
Immunohistochemistry (IHC) 50 Antibodies 19 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 5 Antibodies 3 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 1 Antibodies
Immunofluorescence (IF) 14 Antibodies 4 Antibodies
Immunocytochemistry (ICC) 16 Antibodies 7 Antibodies

General

Antigen FYN Oncogene Related To SRC, FGR, YES (FYN) Antibodies
Reactivity Human, Mouse (Murine)
(184), (88), (37), (7), (7), (7), (2), (1), (1), (1), (1)
Host Mouse
(128), (64), (16)
Clonality (Clone)
Monoclonal   ( )
Conjugate This FYN antibody is un-conjugated
(8), (7), (7), (7), (7), (7)
Application Biochemical Assay (BCA)
(189), (112), (49), (25), (24), (18), (14), (12), (6), (4), (2), (2), (2), (1), (1)
Pubmed 4 references available
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Product Details anti-FYN Antibody

Target Details FYN Application Details Handling References for anti-FYN Antibody (ABIN2666047) Images
Purification The antibody was purified by affinity chromatography.
Clone FYN-59
Isotype IgG

Target Details FYN

Product Details anti-FYN Antibody Application Details Handling References for anti-FYN Antibody (ABIN2666047) Images back to top
Antigen
Alternative Name Fyn (FYN Antibody Abstract)
Background Fyn is a 59 kD protein tyrosine kinase and a member of the src subfamily. There are two reported isoforms of Fyn, FynT found in T cells, B cells and thymocytes, and FynB found in neuronal cells. Fyn has been shown to control cell growth, interact with the p85 subunit of PI3K, control high affinity IgE receptor-mediated mast cell degranulation, and participate in neuronal cell signaling. Fyn can be activated by T cell receptor engagement or anti-CD3 ligation. Fyn is known to be modified by phosphorylation and palmitoylation and has been shown to interact with Fyn binding protein, p85 PI3K, high affinity IgE receptor, and NCAM140. The FYN-59 monoclonal antibody recognizes human and mouse Fyn and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry.
Research Area Cancer, Tyrosine Kinases, Alzheimer's Disease, Signaling
Pathways JAK-STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-FYN Antibody Target Details FYN Handling References for anti-FYN Antibody (ABIN2666047) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-FYN Antibody Target Details FYN Application Details References for anti-FYN Antibody (ABIN2666047) Images back to top
Concentration 0.5 mg/mL
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide at 0.5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Upon receipt, store antibody solution undiluted between 2°C and 8°C.

References for anti-FYN Antibody (ABIN2666047)

Product Details anti-FYN Antibody Target Details FYN Application Details Handling Images back to top
Background publications

Laird, Laky, Hayes: "Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing γδ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 11, pp. 6518-27, 2010

Goldsmith, Hall, Atkinson: "Identification of an alternatively spliced isoform of the fyn tyrosine kinase." in: Biochemical and biophysical research communications, Vol. 298, Issue 4, pp. 501-4, 2002

Prasad, Janssen, Kapeller, Raab, Cantley, Rudd: "Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 15, pp. 7366-70, 1993

Kawakami, Pennington, Robbins: "Isolation and oncogenic potential of a novel human src-like gene." in: Molecular and cellular biology, Vol. 6, Issue 12, pp. 4195-201, 1987

Images

Product Details anti-FYN Antibody Target Details FYN Application Details Handling References for anti-FYN Antibody (ABIN2666047) back to top
Supplier Images
Western Blotting (WB) image for anti-FYN antibody (FYN Oncogene Related To SRC, FGR, YES) (ABIN2666047) anti-FYN Oncogene Related To SRC, FGR, YES (FYN) antibody