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anti-Human FYN antibody for Immunofluorescence

Recommended FYN Antibody (supplied by: Log in to see )

Antigen
FYN Oncogene Related To SRC, FGR, YES (FYN) Antibodies
  • AI448320
  • AW552119
  • c-fyn
  • cfyn-a
  • fyn
  • im:6908851
  • p59-FYN
  • PKC
  • si:dkey-119m7.5
  • SLK
  • SYN
  • zgc:86720
  • zgc:109996
Epitope
AA 1-132
56
34
20
20
15
8
5
5
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Rat (Rattus)
223
125
38
7
7
6
2
1
1
1
1
Host
Mouse
132
99
16
Clonality
Monoclonal
Conjugate
This FYN antibody is un-conjugated
9
9
8
8
7
7
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
227
114
65
40
39
30
27
19
6
4
2
2
2
2
1
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Catalog No. ABIN967788
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.32040194 ABIN967789 IF IP IHC WB Mouse IgG2b AA 1-132 Log in to see 25-FYN 4
0.32040194 ABIN1107284 EIA IF IHC (p) WB Mouse IgG1 Log in to see 2A10 2
0.32040194 ABIN2854964 ICC IF WB Rabbit IgG Center Log in to see Polyclonal
0.32040194 ABIN488060 IF WB Rabbit AA 1-227, N-Term Log in to see Polyclonal
0.0010840179 ABIN120706 IF IHC (p) IP WB Mouse IgG2b AA 7-176 Log in to see FYN-01
0.0010840179 ABIN966166 FACS IF IHC ELISA WB Mouse IgG1 Log in to see 2A10 2
0.0010840179 ABIN1959883 ICC FACS IF IHC (p) ELISA WB Mouse IgG1 Log in to see 2A10
0.0010840179 ABIN269149 ICC IF IHC (p) IP IHC WB Mouse IgG2b Log in to see FYN-01 3
0.0010840179 ABIN442044 ICC IF WB Rabbit IgG Log in to see Polyclonal
0.0010840179 ABIN865401 FACS IF IHC ELISA WB Mouse IgG1 Log in to see 2A10
0.0010840179 ABIN4312917 ICC IF IHC IHC (p) IP WB DyLight 350 Mouse IgG2b Log in to see FYN-01
0.0010840179 ABIN4312918 ICC IF IHC IHC (p) IP WB DyLight 405 Mouse IgG2b Log in to see FYN-01
0.0010840179 ABIN4312920 ICC IF IHC IHC (p) IP WB PerCP Mouse IgG2b Log in to see FYN-01
0.0010840179 ABIN4312921 ICC IF IHC IHC (p) IP WB Allophycocyanin Mouse IgG2b Log in to see FYN-01
0.0010840179 ABIN4312923 ICC IF IHC IHC (p) IP WB DyLight 680 Mouse IgG2b Log in to see FYN-01
0.0010840179 ABIN4312924 ICC IF IHC IHC (p) IP WB DyLight 488 Mouse IgG2b Log in to see FYN-01
0.0010840179 ABIN4312925 ICC IF IHC IHC (p) IP WB DyLight 405LS Mouse IgG2b Log in to see FYN-01
0.0010840179 ABIN4312926 ICC IF IHC IHC (p) IP WB Alexa Fluor 405 Mouse IgG2b Log in to see FYN-01
0.0010840179 ABIN4312928 ICC IF IHC IHC (p) IP WB Alexa Fluor 647 Mouse IgG2b Log in to see FYN-01
0.0010840179 ABIN4312929 ICC IF IHC IHC (p) IP WB Alexa Fluor 700 Mouse IgG2b Log in to see FYN-01

Top referenced anti-FYN antibody for Immunofluorescence

Similar anti-FYN Antibodies

Application / Reactivity Rat (Rattus) Human
ELISA 16 Antibodies 99 Antibodies
Immunocytochemistry (ICC) 1 Antibodies 30 Antibodies
Immunofluorescence (IF) 3 Antibodies 28 Antibodies
Immunohistochemistry (IHC) 12 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 3 Antibodies
Immunoprecipitation (IP) 4 Antibodies
Western Blotting (WB) 34 Antibodies
Biochemical Assay (BCA) 2 Antibodies
Enzyme Immunoassay (EIA) 4 Antibodies
Flow Cytometry (FACS) 19 Antibodies
Functional Studies (Func) 1 Antibodies
Immunochromatography (IC) 2 Antibodies

General

Antigen FYN Oncogene Related To SRC, FGR, YES (FYN) Antibodies
Epitope AA 1-132
(56), (34), (20), (20), (15), (8), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Dog (Canine), Human, Rat (Rattus)
(223), (125), (38), (7), (7), (6), (2), (1), (1), (1), (1)
Host Mouse
(132), (99), (16)
Clonality (Clone)
Monoclonal   ( )
Conjugate This FYN antibody is un-conjugated
(9), (9), (8), (8), (7), (7), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(227), (114), (65), (40), (39), (30), (27), (19), (6), (4), (2), (2), (2), (2), (1)
Pubmed 4 references available
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Product Details anti-FYN Antibody

Target Details FYN Application Details Handling References for anti-FYN Antibody (ABIN967788) Images
Cross-Reactivity Dog (Canine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human fyn aa. 1-132
Clone 25-FYN
Isotype IgG2b

Target Details FYN

Product Details anti-FYN Antibody Application Details Handling References for anti-FYN Antibody (ABIN967788) Images back to top
Antigen
Alternative Name Fyn (FYN Antibody Abstract)
Background Stimulation of the T cell antigen receptor (TcR) results in protein tyrosine phosphorylation via non-receptor tyrosine kinases. The src-related p59[fyn] kinase is one such enzyme that associates with the TcR. Ligation of the TcR activates the protein kinase activity of p59[fyn] in various human T cells. Fyn interacts with the CD3-zeta chains through its N-terminal region. In turn, fyn binds other proteins through its SH2 and SH3 domains. These proteins (p82 and p116) may serve as substrates and/or mediators of fyn activity. A 72 kDa fyn-related protein binds to the TcR/CD3 complex in certain T cells. This protein, known as p72[fyn-R], is a variant of the fyn kinase and contains at least four novel Ser/Thr phosphorylation sites. These sites may make p72[fyn-R] less susceptible to the action of phosphatases than p59[fyn]. Like p59[fyn], p72[fyn-R] is constitutively associated with its receptor. The exact relationship between these two proteins is not yet clear. However, p72[fyn-R] immunoprecipitates with various antisera raised to either the N- or C-terminus of fyn. Similar to src and yes, fyn is highly expressed in brain. The localization of fyn in mouse brain and its interaction with myelin-associated glycoprotein (MAG) suggests that the fyn kinase has a role in the sensory network and in myelination during early stages of CNS formation.
Molecular Weight 59 kDa
Research Area Cancer, Tyrosine Kinases, Alzheimer's Disease, Signaling
Pathways JAK-STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-FYN Antibody Target Details FYN Handling References for anti-FYN Antibody (ABIN967788) Images back to top
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only

Handling

Product Details anti-FYN Antibody Target Details FYN Application Details References for anti-FYN Antibody (ABIN967788) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.

References for anti-FYN Antibody (ABIN967788)

Product Details anti-FYN Antibody Target Details FYN Application Details Handling Images back to top
Product cited in:

Zeng, Si, Yu, Le, Ng, Teng, Ryan, Wang, Ponniah, Pallen: "PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration." in: The Journal of cell biology, Vol. 160, Issue 1, pp. 137-46, 2003

Feuillet, Semichon, Restouin, Harriague, Janzen, Magee, Collette, Bismuth: "The distinct capacity of Fyn and Lck to phosphorylate Sam68 in T cells is essentially governed by SH3/SH2-catalytic domain linker interactions." in: Oncogene, Vol. 21, Issue 47, pp. 7205-13, 2002

Derkinderen, Toutant, Kadaré, Ledent, Parmentier, Girault: "Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus." in: The Journal of biological chemistry, Vol. 276, Issue 41, pp. 38289-96, 2001

Kawakami, Kawakami, Aaronson, Robbins: "Acquisition of transforming properties by FYN, a normal SRC-related human gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 11, pp. 3870-4, 1988

Images

Product Details anti-FYN Antibody Target Details FYN Application Details Handling References for anti-FYN Antibody (ABIN967788) back to top
Supplier Images
Western Blotting (WB) image for anti-FYN antibody (FYN Oncogene Related To SRC, FGR, YES) (AA 1-132) (ABIN967788) Western blot analysis of fyn on Jurkat cell lysate. Lane 1: 1:250, lane 2: 1: 500, la...
Immunofluorescence (IF) image for anti-FYN antibody (FYN Oncogene Related To SRC, FGR, YES) (AA 1-132) (ABIN967788) Immunofluorescent staining of A431 cells with anti-fyn antibody.