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|Application / Reactivity||Human||Mouse (Murine)|
|Western Blotting (WB)||176 Antibodies||78 Antibodies|
|Proximity Ligation Assay (PLA)||2 Antibodies|
|Immunoprecipitation (IP)||27 Antibodies||12 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||22 Antibodies||15 Antibodies|
|Immunohistochemistry (IHC)||50 Antibodies||19 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||5 Antibodies||3 Antibodies|
|Immunohistochemistry (Acetone-fixed) (IHC (af))||1 Antibodies|
|Immunofluorescence (IF)||14 Antibodies||4 Antibodies|
|Immunocytochemistry (ICC)||16 Antibodies||7 Antibodies|
|Antigen||FYN Oncogene Related To SRC, FGR, YES (FYN) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This FYN antibody is un-conjugated Alternatives|
Biochemical Assay (BCA)
|4 references available|
|Supplier||Log in to see|
Product Details anti-FYN AntibodyTarget Details FYN Application Details Handling References for anti-FYN Antibody (ABIN2666047) Images
|Purification||The antibody was purified by affinity chromatography.|
Target Details FYNProduct Details anti-FYN Antibody Application Details Handling References for anti-FYN Antibody (ABIN2666047) Images back to top
|Alternative Name||Fyn (FYN Antibody Abstract)|
|Background||Fyn is a 59 kD protein tyrosine kinase and a member of the src subfamily. There are two reported isoforms of Fyn, FynT found in T cells, B cells and thymocytes, and FynB found in neuronal cells. Fyn has been shown to control cell growth, interact with the p85 subunit of PI3K, control high affinity IgE receptor-mediated mast cell degranulation, and participate in neuronal cell signaling. Fyn can be activated by T cell receptor engagement or anti-CD3 ligation. Fyn is known to be modified by phosphorylation and palmitoylation and has been shown to interact with Fyn binding protein, p85 PI3K, high affinity IgE receptor, and NCAM140. The FYN-59 monoclonal antibody recognizes human and mouse Fyn and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry.|
|Research Area||Cancer, Tyrosine Kinases, Alzheimer's Disease, Signaling|
|Pathways||JAK-STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-FYN Antibody Target Details FYN Handling References for anti-FYN Antibody (ABIN2666047) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-FYN Antibody Target Details FYN Application Details References for anti-FYN Antibody (ABIN2666047) Images back to top
|Buffer||phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide at 0.5 mg/mL.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Upon receipt, store antibody solution undiluted between 2°C and 8°C.|
References for anti-FYN Antibody (ABIN2666047)Product Details anti-FYN Antibody Target Details FYN Application Details Handling Images back to top
Laird, Laky, Hayes: "Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing γδ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 11, pp. 6518-27, 2010 (PubMed).
Goldsmith, Hall, Atkinson: "Identification of an alternatively spliced isoform of the fyn tyrosine kinase." in: Biochemical and biophysical research communications, Vol. 298, Issue 4, pp. 501-4, 2002 (PubMed).
Prasad, Janssen, Kapeller et al.: "Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 15, pp. 7366-70, 1993 (PubMed).
Kawakami, Pennington, Robbins: "Isolation and oncogenic potential of a novel human src-like gene." in: Molecular and cellular biology, Vol. 6, Issue 12, pp. 4195-201, 1987 (PubMed).
ImagesProduct Details anti-FYN Antibody Target Details FYN Application Details Handling References for anti-FYN Antibody (ABIN2666047) back to top