anti-Human IL15 antibody for Immunocytochemistry

Recommended IL15 Antibody (supplied by: Log in to see )

Antigen
Interleukin 15 (IL15) Antibodies
  • IL15
  • AI503618
  • IL-15
  • interleukin 15
  • IL15
  • Il15
Reactivity
Human
239
67
27
10
8
6
5
2
2
1
1
1
Host
Mouse
147
135
18
17
5
5
Clonality
Monoclonal
Conjugate
This IL15 antibody is un-conjugated
37
17
11
10
8
6
6
6
6
5
5
3
3
3
3
3
3
3
3
3
3
2
2
1
Application
Functional Studies (Func), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
210
183
66
47
32
28
27
16
13
11
9
7
5
4
4
3
3
3
1
1
1
1
1
1
1
1
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Catalog No. ABIN2665113
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN5077490 ICC IF Rabbit IgG Log in to see Polyclonal
1 ABIN1172117 ICC IHC IP WB Rabbit IgG AA 50-162 Log in to see Polyclonal
1 ABIN2665112 Func ICC FACS IP Mouse IgG1 kappa Log in to see BH1509 9
1 ABIN5565742 FACS ICC IF IHC APC Rabbit AA 49-162 Log in to see Polyclonal
1 ABIN5565745 FACS ICC IF IHC PE Rabbit AA 49-162 Log in to see Polyclonal
1 ABIN5565743 FACS ICC IF IHC FITC Rabbit AA 49-162 Log in to see Polyclonal

General

Antigen Interleukin 15 (IL15) Antibodies
Reactivity Human
(239), (67), (27), (10), (8), (6), (5), (2), (2), (1), (1), (1)
Host Mouse
(147), (135), (18), (17), (5), (5)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL15 antibody is un-conjugated
(37), (17), (11), (10), (8), (6), (6), (6), (6), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1)
Application Functional Studies (Func), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
(210), (183), (66), (47), (32), (28), (27), (16), (13), (11), (9), (7), (5), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 9 references available
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Product Details anti-IL15 Antibody

Target Details IL15 Application Details Handling References for anti-IL15 antibody (ABIN2665113) Images
Purification The antibody was purified by affinity chromatography.
Clone BH1509
Isotype IgG1 kappa

Target Details IL15

Product Details anti-IL15 Antibody Application Details Handling References for anti-IL15 antibody (ABIN2665113) Images back to top
Antigen
Alternative Name IL-15 (IL15 Antibody Abstract)
Background Interleukin-15 (IL-15) was discovered in supernatant from simian kidney epithelial cell line CV-1/EBNA, as a soluble factor capable of supporting proliferation of the IL-2-dependent cell line, CTLL-2 (1). IL-15 is a regulatory cytokine that is produced by dendritic cells, epithelial cells, human stromal cell line (IMTLH), fibroblasts, and monocytes (2). It plays an important role in immune response and shares many functions with IL-2, for example, it stimulates the proliferation of activated T cells (1, 2), NK cells (3) and B cells, and it induces immunoglobulin synthesis by B cells stimulated by anti-IgM or CD40 ligand (4). In addition, IL-15 promotes the development of dendritic cells (5), activates human neutrophils (6, 7) and induces the production of proinflammatory cytokines from macrophages (8). IL-15 acts as a bridge between innate and adaptive immunity because of its diverse roles in the immune system. IL-15 binds to heterotrimeric receptors composed of IL-15Rα, IL-15Rβ, and IL-15Rγc. IL-15 shares with IL-2 the receptor chains β and γc. IL-15 is normally not secreted in soluble form but is held on the cell surface bound to a unique receptor, IL-15Rα, especially on dendritic cells. Cell-bound IL-15 then is presented in trans to T cells and NK cells and is recognized by the γc receptor on these cells, such recognition maintains cell survival and intermittent proliferation (9).
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Pathways JAK-STAT Signaling, Glycosaminoglycan Metabolic Process

Application Details

Product Details anti-IL15 Antibody Target Details IL15 Handling References for anti-IL15 antibody (ABIN2665113) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL15 Antibody Target Details IL15 Application Details References for anti-IL15 antibody (ABIN2665113) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL15 antibody (ABIN2665113)

Product Details anti-IL15 Antibody Target Details IL15 Application Details Handling Images back to top
Background publications

Tang, Zhao, Jiang, Ba, Cui, He: "Activity of recombinant human interleukin-15 against tumor recurrence and metastasis in mice." in: Cellular & molecular immunology, Vol. 5, Issue 3, pp. 189-96, 2008

Rubinstein, Kovar, Purton, Cho, Boyman, Surh, Sprent: "Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 24, pp. 9166-71, 2006

Ma, Koka, Burkett: "Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis." in: Annual review of immunology, Vol. 24, pp. 657-79, 2006

Bouchard, Ratthé, Girard: "Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8." in: Journal of leukocyte biology, Vol. 75, Issue 5, pp. 893-900, 2004

Meresse, Chen, Ciszewski, Tretiakova, Bhagat, Krausz, Raulet, Lanier, Groh, Spies, Ebert, Green, Jabri: "Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease." in: Immunity, Vol. 21, Issue 3, pp. 357-66, 2004

Pulendran, Dillon, Joseph, Curiel, Banchereau, Mohamadzadeh: "Dendritic cells generated in the presence of GM-CSF plus IL-15 prime potent CD8+ Tc1 responses in vivo." in: European journal of immunology, Vol. 34, Issue 1, pp. 66-73, 2004

Ratthé, Girard: "Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain." in: Journal of leukocyte biology, Vol. 76, Issue 1, pp. 162-8, 2004

Armitage, Macduff, Eisenman, Paxton, Grabstein: "IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 2, pp. 483-90, 1995

Grabstein, Eisenman, Shanebeck, Rauch, Srinivasan, Fung, Beers, Richardson, Schoenborn, Ahdieh: "Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor." in: Science (New York, N.Y.), Vol. 264, Issue 5161, pp. 965-8, 1994

Images

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Supplier Images
ELISA image for anti-Interleukin 15 (IL15) antibody (ABIN2665113) anti-Interleukin 15 (IL15) antibody