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anti-Human IL15 antibody for Neutralization

Recommended IL15 Antibody (supplied by: Log in to see )

Antigen
Interleukin 15 (IL15) Antibodies
  • AI503618
  • IL-15
  • IL15
Reactivity
Human
193
45
22
7
6
6
3
1
1
Host
Mouse
132
97
11
7
5
5
Clonality
Monoclonal
Conjugate
This IL15 antibody is un-conjugated
32
16
10
6
5
5
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Neutralization (Neut)
176
161
35
34
26
22
12
11
9
8
8
6
6
5
3
1
1
1
1
1
1
Supplier
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Catalog No. ABIN2680316
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008739339 ABIN464930 Neut ELISA WB Rabbit Log in to see Polyclonal
0.0008739339 ABIN208838 IP Neut ELISA WB Rabbit IgG Log in to see Polyclonal
0.0008739339 ABIN1983256 Neut WB Mouse IgG1 AA 49-162 Log in to see MM0368-13S34
0.0008739339 ABIN4324539 BP Neut WB Mouse IgG1 Log in to see MM0368-13S34
0.0008739339 ABIN2287807 Neut ELISA WB APC Rabbit IgG Log in to see Polyclonal
0.0008739339 ABIN2287808 Neut ELISA WB Biotin Rabbit IgG Log in to see Polyclonal
0.0008739339 ABIN2287812 Neut ELISA WB HRP Rabbit IgG Log in to see Polyclonal
0.0008739339 ABIN2287803 Neut ELISA WB Rabbit IgG Log in to see Polyclonal
0.0008739339 ABIN2287805 Neut ELISA WB Alkaline Phosphatase (AP) Rabbit IgG Log in to see Polyclonal
0.0008739339 ABIN2287810 Neut ELISA WB FITC Rabbit IgG Log in to see Polyclonal
0.0008739339 ABIN2287814 Neut ELISA WB PE Rabbit IgG Log in to see Polyclonal
0.0008739339 ABIN2287774 IP Neut ELISA WB Rabbit IgG Log in to see Polyclonal

Similar anti-IL15 Antibodies

Application / Reactivity Human
Blocking Antibody (Inhibition) 4 Antibodies
Cellular Assay (CA) 1 Antibodies
Dot Blot (DB) 6 Antibodies
ELISA 148 Antibodies
Enzyme Immunoassay (EIA) 6 Antibodies
Flow Cytometry (FACS) 12 Antibodies
Functional Studies (Func) 8 Antibodies
Immunoassay (IA) 3 Antibodies
Immunocytochemistry (ICC) 3 Antibodies
Immunofluorescence (IF) 6 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 1 Antibodies
Immunohistochemistry (IHC) 33 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 28 Antibodies
Immunoprecipitation (IP) 26 Antibodies
Immunostaining (ISt) 1 Antibodies
Neutralization (Neut) 13 Antibodies
Transfected Cell Culture (TCC) 1 Antibodies
Western Blotting (WB) 116 Antibodies

General

Antigen Interleukin 15 (IL15) Antibodies
Reactivity Human
(193), (45), (22), (7), (6), (6), (3), (1), (1)
Host Mouse
(132), (97), (11), (7), (5), (5)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL15 antibody is un-conjugated
(32), (16), (10), (6), (5), (5), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Neutralization (Neut)
(176), (161), (35), (34), (26), (22), (12), (11), (9), (8), (8), (6), (6), (5), (3), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-IL15 Antibody

Target Details IL15 Application Details Handling References for anti-IL15 Antibody (ABIN2680316) Images
Specificity The ct2nu monoclonal antibody reacts with human IL-15 and neutralizes its bioactivity. IL-15, or IL-T, is a 14 kDa proinflammatory cytokine and member of the IL-2 family. It plays a role in the development and maturation of macrophages and dendritic cells, and is essential to the proliferation and survival of NK cells and CD8+ T cells.

IL-15 is expressed by antigen-presenting cells, epithelial cells, and stromal cells. IL-15 activates the Jak/STAT pathway through its heterotrimeric receptor. Two subunits of this receptor, the β and γ chains, are shared with the rest of the family, while the α subunit is unique to IL-15. In mice, the α chain is required to chaperone IL-15 from the ER to secretion. This chaperoning is not necessary in humans, and free IL-15 is detectable in human biological samples. However, the receptor-cytokine complex has been indentified in humans and demonstrates agonistic activity several-fold higher than IL-15 alone.
Characteristics The ct2nu monoclonal antibody reacts with human IL-15 and neutralizes its bioactivity. IL-15, or IL-T, is a 14 kDa proinflammatory cytokine and member of the IL-2 family. It plays a role in the development and maturation of macrophages and dendritic cells, and is essential to the proliferation and survival of NK cells and CD8 + T cells. IL-15 is expressed by antigen-presenting cells, epithelial cells, and stromal cells. IL-15 activates the Jak/STAT pathway through its heterotrimeric receptor. Two subunits of this receptor, the β and γ chains, are shared with the rest of the family, while the α subunit is unique to IL-15. In mice, the α chain is required to chaperone IL-15 from the ER to secretion. This chaperoning is not necessary in humans, and free IL-15 is detectable in human biological samples. However, the receptor-cytokine complex has been indentified in humans and demonstrates agonistic activity several-fold higher than IL-15 alone.
Purification Affinity Purified
Endotoxin Level <0.001 ng endotoxin/μg
Grade Functional Grade
Clone Ct2nu
Isotype IgG1 kappa

Target Details IL15

Product Details anti-IL15 Antibody Application Details Handling References for anti-IL15 Antibody (ABIN2680316) Images back to top
Antigen
Alternative Name IL-15 (IL15 Antibody Abstract)
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Pathways JAK-STAT Signaling

Application Details

Product Details anti-IL15 Antibody Target Details IL15 Handling References for anti-IL15 Antibody (ABIN2680316) Images back to top
Application Notes Applications reported: The monoclonal antibody ct2nu reacts with and inhibits the bioactivity of human IL-15.

Applications tested: The ND50 of this antibody, as measured by inhibition of proliferation in CTLL-2 cells, is 1-10 ng/mL in the presence of 0.5 ng/mL recombinant human IL-15. Neutralization dose will vary based on cell type, cytokine concentration, and assay method. This antibody should be carefully titrated for optimal performance in the assay of interest.
Restrictions For Research Use only

Handling

Product Details anti-IL15 Antibody Target Details IL15 Application Details References for anti-IL15 Antibody (ABIN2680316) Images back to top
Concentration 1 mg/mL
Buffer aqueous buffer, no sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze/thaw cycles. KEEP CONTENTS STERILE.
Storage 4 °C
Storage Comment Store at 2-8°C.

References for anti-IL15 Antibody (ABIN2680316)

Product Details anti-IL15 Antibody Target Details IL15 Application Details Handling Images back to top
Background publications

Fehniger, Caligiuri: "Interleukin 15: biology and relevance to human disease." in: Blood, Vol. 97, Issue 1, pp. 14-32, 2001