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|Application / Reactivity||Human|
|Complement Mediated Cell Depletion (CMCD)||1 Antibodies|
|Depletion (Dep)||1 Antibodies|
|ELISA (Capture)||1 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|Flow Cytometry (FACS)||8 Antibodies|
|Gel Shift (GS)||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||7 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||3 Antibodies|
|Immunoprecipitation (IP)||3 Antibodies|
|Western Blotting (WB)||51 Antibodies|
|Antigen||Interleukin 15 Receptor, alpha (IL15RA) Antibodies|
|Conjugate||This IL15RA antibody is conjugated to Biotin Alternatives|
Complement Mediated Cell Depletion (CMCD), Depletion (Dep), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|9 references available|
|Supplier||Log in to see|
Product Details anti-IL15RA AntibodyTarget Details IL15RA Application Details Handling References for anti-IL15RA Antibody (ABIN2660994) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.|
Target Details IL15RAProduct Details anti-IL15RA Antibody Application Details Handling References for anti-IL15RA Antibody (ABIN2660994) Images back to top
|Alternative Name||CD215 (IL15RA Antibody Abstract)|
|Background||IL-15 receptor α (IL-15Rα) is a cytokine receptor with the structural homology to IL-2Rα (CD25). Both α receptors contain a group of β sandwich protein called sushi domains. Similar to IL-2Rα, IL-15Rα is able to form a heterotrimer with their β chain (CD122) and common γ chain (γc, CD132). But unlike IL-2Rα subunit, IL-15Rα itself binds to IL-15 with equivalent high affinity compared with the heterotrimeric complex. IL-15Rα is expressed as soluble or transmembrane forms by variety cells, such as activated monocytes, dendritic cells, CD8+ memory T cells, NK or NKT cells. IL-15Rα by itself forms stable complexes with IL-15 on cell surface and presents IL-15 in trans to neighboring cells. IL-15, like IL-2, is a pleiotropic four-helix bundle cytokine and plays a key role in promoting T and B cell survival and proliferation, preferentially in memory CD8+ T cell proliferation, and NK/NKT cell development.|
|Pathways||JAK-STAT Signaling, TCR Signaling|
Application DetailsProduct Details anti-IL15RA Antibody Target Details IL15RA Handling References for anti-IL15RA Antibody (ABIN2660994) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL15RA Antibody Target Details IL15RA Application Details References for anti-IL15RA Antibody (ABIN2660994) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-IL15RA Antibody (ABIN2660994)Product Details anti-IL15RA Antibody Target Details IL15RA Application Details Handling Images back to top
Kitaya, Yasuo: "Regulatory role of membrane-bound form interleukin-15 on human uterine microvascular endothelial cells in circulating CD16(-) natural killer cell extravasation into human endometrium." in: Biology of reproduction, Vol. 89, Issue 3, pp. 70, 2013 (PubMed).
Veerman, Carlow, Shanina et al.: "PSGL-1 regulates the migration and proliferation of CD8(+) T cells under homeostatic conditions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 4, pp. 1638-46, 2012 (PubMed).
Vujanovic, Szymkowski, Alber et al.: "Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15." in: Blood, Vol. 116, Issue 4, pp. 575-83, 2010 (PubMed).
Sato, Patel, Waldmann et al.: "The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 2, pp. 588-93, 2007 (PubMed).
Lorenzen, Dingley, Jacques et al.: "The structure of the interleukin-15 alpha receptor and its implications for ligand binding." in: The Journal of biological chemistry, Vol. 281, Issue 10, pp. 6642-7, 2006 (PubMed).
Giron-Michel, Giuliani, Fogli et al.: "Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors." in: Blood, Vol. 106, Issue 7, pp. 2302-10, 2005 (PubMed).
Vámosi, Bodnár, Vereb et al.: "IL-2 and IL-15 receptor alpha-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 30, pp. 11082-7, 2004 (PubMed).
Dubois, Mariner, Waldmann et al.: "IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells." in: Immunity, Vol. 17, Issue 5, pp. 537-47, 2002 (PubMed).
Giri, Kumaki, Ahdieh et al.: "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor." in: The EMBO journal, Vol. 14, Issue 15, pp. 3654-63, 1995 (PubMed).
ImagesProduct Details anti-IL15RA Antibody Target Details IL15RA Application Details Handling References for anti-IL15RA Antibody (ABIN2660994) back to top