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anti-Human IL21 Receptor Antibodies:
anti-Mouse (Murine) IL21 Receptor Antibodies:
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Human Polyclonal IL21 Receptor Primary Antibody for CyTOF, FACS - ABIN4899488
Baan, Balk, Dijke, Korevaar, Peeters, de Kuiper, Klepper, Zondervan, Maat, Weimar: Interleukin-21: an interleukin-2 dependent player in rejection processes. in Transplantation 2007
Show all 6 Pubmed References
Human Monoclonal IL21 Receptor Primary Antibody for FACS - ABIN4896192
Sarra, Caruso, Cupi, Monteleone, Stolfi, Campione, Diluvio, Mazzotta, Botti, Chimenti, Costanzo, MacDonald, Pallone, Monteleone: IL-21 promotes skin recruitment of CD4(+) cells and drives IFN-?-dependent epidermal hyperplasia. in Journal of immunology (Baltimore, Md. : 1950) 2011
Show all 5 Pubmed References
Human Monoclonal IL21 Receptor Primary Antibody for FACS - ABIN4896191
de Totero, Capaia, Fabbi, Croce, Meazza, Cutrona, Zupo, Loiacono, Truini, Ferrarini, Ferrini: Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells. in Experimental hematology 2010
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Human Polyclonal IL21 Receptor Primary Antibody for ELISA, WB - ABIN1002624
Asao, Okuyama, Kumaki, Ishii, Tsuchiya, Foster, Sugamura: Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. in Journal of immunology (Baltimore, Md. : 1950) 2001
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Human Polyclonal IL21 Receptor Primary Antibody for IHC, ELISA - ABIN1002623
Ozaki, Kikly, Michalovich, Young, Leonard: Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. in Proceedings of the National Academy of Sciences of the United States of America 2000
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Human Monoclonal IL21 Receptor Primary Antibody for CyTOF, FACS - ABIN4899489
Ansén, Butler, Berezovskaya, Murray, Stevenson, Nadler, Hirano: Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008
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Mouse (Murine) Monoclonal IL21 Receptor Primary Antibody for FACS - ABIN4896194
Caruso, Fina, Peluso, Fantini, Tosti, Del Vecchio Blanco, Paoluzi, Caprioli, Andrei, Stolfi, Romano, Ricci, MacDonald, Pallone, Monteleone: IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. in Journal of immunology (Baltimore, Md. : 1950) 2007
Show all 2 Pubmed References
Mouse (Murine) Monoclonal IL21 Receptor Primary Antibody for FACS - ABIN4896193
Biswas, Gupta, Stirzaker, Kumar, Jessberger, Lu, Bhagat, Pernis: Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity. in The Journal of experimental medicine 2012
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Human Polyclonal IL21 Receptor Primary Antibody for WB - ABIN2474984
Parrish-Novak, Dillon, Nelson, Hammond, Sprecher, Gross, Johnston, Madden, Xu, West, Schrader, Burkhead, Heipel, Brandt, Kuijper, Kramer, Conklin, Presnell, Berry, Shiota, Bort, Hambly, Mudri, Clegg et al.: Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. ... in Nature 2000
Human Polyclonal IL21 Receptor Primary Antibody for FACS, WB - ABIN4899487
Alves, Arosa, van Lier: IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells. in Journal of immunology (Baltimore, Md. : 1950) 2005
IL21R is probably not causally involved in recurrent airway obstruction.
bone marrow monocytes from multiple myeloma patients show distinct features compared to those from patients with indolent monoclonal gammopathies, supporting the role of IL21R over-expression by bone marrow CD14 (show NDUFA2 Antibodies)(+) cells in enhanced osteoclast formation.
Report increased levels of IL-21R in the skeletal muscle endothelial cells of patients with peripheral arterial disease compared to control individuals.
expression of IL-21 (show IL17C Antibodies) and IL-21R were up-regulated in autoimmune thyroid disease and may be involved in the pathogenesis of the disease through augmenting aberrant immune cascade
interleukin-21 receptor deficiency is associated with Severe Combined Immunodeficiency (show PRKDC Antibodies).
IL-21R on B cells is upregulated in allergic rhinitis patients when compared to controls. IL-21/IL-21R may be involved in the regulation of allergic reactions through the inhibition of IgE.
IL-21 (show IL17C Antibodies)/IL-21R could act as potential biomarkers presenting early systemic sclerosis skin lesions severity.
STAT3 (show STAT3 Antibodies) signaling downstream of IL-23R (show IL23R Antibodies) and IL-21R has a role in controlling human mucosal-associated invariant T cells and NKT (show SLC22A6 Antibodies) cell numbers
Human neutrophils in peripheral blood express functional IL-21 (show IL17C Antibodies) receptors.
IL-21R gene polymorphisms and serum IL-21 (show IL17C Antibodies) levels predict virological response to interferon (show IFNA Antibodies)-based therapy in Asian chronic hepatitis C patients.
Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease.
natural genetic variation in murine Il21r influences neuronal cell viability after ischemia by modulating receptor function and downstream signal transduction
IL-21 (show IL21 Antibodies) may play an important role in the pathogenesis of SSc (show CYP11A1 Antibodies) as a Th17 effector cytokine, and IL-21 (show IL21 Antibodies) may induce the differentiation of Th17 cells in the BLM-induced systemic sclerosis mouse model via Il21R.
Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21 (show IL21 Antibodies), IL21R, and a series of genes associated with TFH cell development and function.
IIl21r deletion reduced spontaneous EAE associated with defective Th17 cell generation. IL-21R deficiency limited IL-23R (show IL23R Antibodies) expression on Th17 cells and inhibited expression of key molecules for pathogenic Th17 cell generation.
our data demonstrate the novel finding that the IL-21R plays a critical role in regulating innate immune responses against HSV-2 infection.
During experimental arthritis, IL-21R deficiency protected against severe inflammation and joint destruction. This was accompanied by suppressed serum IgG1 levels and antigen-specific T cell responses.
in the absence of IL-21 (show IL21 Antibodies)/IL-21R signaling, Il2 (show IL2 Antibodies)(-/-) mice retained a deficiency in Tregs yet exhibited a reduced and delayed inflammatory disease which was reflected in reduced pancreatitis and hemolytic anemia
IL-21R expression on donor CD4 (show CD4 Antibodies)+ T cells is essential for sustaining T cell number and help for B cells, resulting in more severe lupus-like renal disease, but it does not alter the balance of T helper (Th)17 cells and regulatory T cells.
IL-21R controls both antigen transport by DCs and the crucial beacon (show UBL5 Antibodies) function of CD4 (show CD4 Antibodies)(+) cells for autoreactive CD8 (show CD8A Antibodies)(+) cells to reach the islets.
Data indicate that CD8KO recipients given either C57Bl/6 or IL-21RKO CD8 (show CD8A Antibodies)+ cells showed the recipients given C57Bl/6 CD8 (show CD8A Antibodies)+ cells with significantly greater myocarditis than recipients of IL-21RKO CD8 (show CD8A Antibodies)+ cells.
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
, interleukin 21 receptor
, interleukin 21 receptor alpha.a
, IL-21 receptor
, novel interleukin receptor
, lymphocyte receptor beta
, novel cytokine receptor 8