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|Application / Reactivity||Human|
|Biochemical Assay (BCA)||4 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies|
|Flow Cytometry (FACS)||7 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (IF)||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||15 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||1 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||11 Antibodies|
|Immunoprecipitation (IP)||2 Antibodies|
|Mass Cytometry (CyTOF)||1 Antibodies|
|Western Blotting (WB)||47 Antibodies|
|Antigen||Interleukin 21 Receptor (IL21R) Antibodies|
|Conjugate||This IL21 Receptor antibody is conjugated to PE Alternatives|
Biochemical Assay (BCA)
|8 references available|
|Supplier||Log in to see|
Product Details anti-IL21 Receptor AntibodyTarget Details IL21 Receptor Application Details Handling References for anti-IL21 Receptor Antibody (ABIN2663416) Images
|Cross-Reactivity||Cynomolgus, Rhesus Monkey|
|Purification||The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details IL21 ReceptorProduct Details anti-IL21 Receptor Antibody Application Details Handling References for anti-IL21 Receptor Antibody (ABIN2663416) Images back to top
|Alternative Name||CD360 (IL21R Antibody Abstract)|
|Background||The human interleukin 21 receptor (IL-21R), is a single pass type I membrane protein and a member of the type I cytokine receptor family. Of the type I cytokine receptors, IL-21R exhibits the greatest extracellular homology to the IL-2R beta subunit, i.e., contains one copy of the WSXWS-containing cytokine-binding domain. Intracellular domains of IL-21R include the Box 1 and Box 2 elements which are similar to the IL-9R intracellular region. Upon binding IL-21, the IL-21R forms a heterodimer with the common gamma subunit (CD132) and induces Jak/Stat signaling. IL-21R is expressed on B cells and at various levels on NK and T cells. IL-21 is a potent immunomodulatory cytokine mainly produced by NKT and CD4 T-cells (particularly the inflammatory Th17 subset) and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhanced proliferation of natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells and direct inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.|
Application DetailsProduct Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Handling References for anti-IL21 Receptor Antibody (ABIN2663416) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Application Details References for anti-IL21 Receptor Antibody (ABIN2663416) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-IL21 Receptor Antibody (ABIN2663416)Product Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Application Details Handling Images back to top
Rodríguez-Bayona, Ramos-Amaya, Bernal et al.: "Cutting edge: IL-21 derived from human follicular helper T cells acts as a survival factor for secondary lymphoid organ, but not for bone marrow, plasma cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 4, pp. 1578-81, 2012 (PubMed).
Davis, Skak, Smyth et al.: "Interleukin-21 signaling: functions in cancer and autoimmunity." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 23, pp. 6926-32, 2007 (PubMed).
de Totero, Meazza, Zupo et al.: "Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells." in: Blood, Vol. 107, Issue 9, pp. 3708-15, 2006 (PubMed).
Parrish-Novak, Foster, Holly et al.: "Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses." in: Journal of leukocyte biology, Vol. 72, Issue 5, pp. 856-63, 2002 (PubMed).
Habib, Senadheera, Weinberg et al.: "The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3." in: Biochemistry, Vol. 41, Issue 27, pp. 8725-31, 2002 (PubMed).
Asao, Okuyama, Kumaki et al.: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, 2001 (PubMed).
Ozaki, Kikly, Michalovich et al.: "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 21, pp. 11439-44, 2000 (PubMed).
Dumoutier, Van Roost, Colau et al.: "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 18, pp. 10144-9, 2000 (PubMed).
ImagesProduct Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Application Details Handling References for anti-IL21 Receptor Antibody (ABIN2663416) back to top