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anti-Human IL21 Receptor antibody for Biochemical Assay

Recommended IL21 Receptor Antibody (supplied by: Log in to see )

Antigen
Interleukin 21 Receptor (IL21R) Antibodies
  • CD360
  • il-21ra.a
  • IL21R
  • NILR
Reactivity
Human
91
50
30
2
Host
Mouse
71
21
15
6
Clonality
Monoclonal
Conjugate
This IL21 Receptor antibody is conjugated to APC
8
6
5
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Biochemical Assay (BCA)
52
38
29
21
13
11
4
3
2
2
2
2
1
1
1
Supplier
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Catalog No. ABIN2658206
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00088740664 ABIN2663416 BCA PE Mouse IgG1 kappa Log in to see 2G1-K12 8
0.00088740664 ABIN2658207 BCA APC Mouse IgG1 kappa Log in to see 2G1-K12 9
0.00088740664 ABIN2663417 BCA PE Mouse IgG1 kappa Log in to see 2G1-K12 8

Top referenced anti-IL21 Receptor antibody for Biochemical Assay

Similar anti-IL21 Receptor Antibodies

Application / Reactivity Human
Biochemical Assay (BCA) 4 Antibodies
ELISA 31 Antibodies
Enzyme Immunoassay (EIA) 2 Antibodies
Flow Cytometry (FACS) 14 Antibodies
Immunocytochemistry (ICC) 2 Antibodies
Immunofluorescence (IF) 3 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 17 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 13 Antibodies
Immunoprecipitation (IP) 2 Antibodies
Mass Cytometry (CyTOF) 1 Antibodies
Western Blotting (WB) 51 Antibodies

General

Antigen Interleukin 21 Receptor (IL21R) Antibodies
Reactivity Human
(91), (50), (30), (2)
Host Mouse
(71), (21), (15), (6)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL21 Receptor antibody is conjugated to APC
(8), (6), (5), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Biochemical Assay (BCA)
(52), (38), (29), (21), (13), (11), (4), (3), (2), (2), (2), (2), (1), (1), (1)
Pubmed 9 references available
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Product Details anti-IL21 Receptor Antibody

Target Details IL21 Receptor Application Details Handling References for anti-IL21 Receptor Antibody (ABIN2658206) Images
Cross-Reactivity Cynomolgus, Rhesus Monkey
Purification The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Clone 2G1-K12
Isotype IgG1 kappa

Target Details IL21 Receptor

Product Details anti-IL21 Receptor Antibody Application Details Handling References for anti-IL21 Receptor Antibody (ABIN2658206) Images back to top
Antigen
Alternative Name CD360 (IL21R Antibody Abstract)
Background The human interleukin 21 receptor (IL-21R), is a single pass type I membrane protein and a member of the type I cytokine receptor family. Of the type I cytokine receptors, IL-21R exhibits the greatest extracellular homology to the IL-2R beta subunit, i.e., contains one copy of the WSXWS-containing cytokine-binding domain. Intracellular domains of IL-21R include the Box 1 and Box 2 elements which are similar to the IL-9R intracellular region. Upon binding IL-21, the IL-21R forms a heterodimer with the common gamma subunit (CD132) and induces Jak/Stat signaling. IL-21R is expressed on B cells and at various levels on NK and T cells. IL-21 is a potent immunomodulatory cytokine mainly produced by NKT and CD4 T-cells (particularly the inflammatory Th17 subset) and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhanced proliferation of natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells and direct inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
Pathways JAK-STAT Signaling

Application Details

Product Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Handling References for anti-IL21 Receptor Antibody (ABIN2658206) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Application Details References for anti-IL21 Receptor Antibody (ABIN2658206) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL21 Receptor Antibody (ABIN2658206)

Product Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Application Details Handling Images back to top
Background publications

Kotlarz, Zi?tara, Uzel, Weidemann, Braun, Diestelhorst, Krawitz, Robinson, Hecht, Pucha?ka, Gertz, Schäffer, Lawrence, Kardava, Pfeifer, Baumann, Pfister, Hanson, Schambach, Jacobs, Kreipe, Moir et al.: "Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome. ..." in: The Journal of experimental medicine, Vol. 210, Issue 3, pp. 433-43, 2013

Rodríguez-Bayona, Ramos-Amaya, Bernal, Campos-Caro, Brieva: "Cutting edge: IL-21 derived from human follicular helper T cells acts as a survival factor for secondary lymphoid organ, but not for bone marrow, plasma cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 4, pp. 1578-81, 2012

Davis, Skak, Smyth, Kristjansen, Miller, Sivakumar: "Interleukin-21 signaling: functions in cancer and autoimmunity." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 23, pp. 6926-32, 2007

de Totero, Meazza, Zupo, Cutrona, Matis, Colombo, Balleari, Pierri, Fabbi, Capaia, Azzarone, Gobbi, Ferrarini, Ferrini: "Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells." in: Blood, Vol. 107, Issue 9, pp. 3708-15, 2006

Parrish-Novak, Foster, Holly, Clegg: "Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses." in: Journal of leukocyte biology, Vol. 72, Issue 5, pp. 856-63, 2002

Habib, Senadheera, Weinberg, Kaushansky: "The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3." in: Biochemistry, Vol. 41, Issue 27, pp. 8725-31, 2002

Asao, Okuyama, Kumaki, Ishii, Tsuchiya, Foster, Sugamura: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, 2001

Dumoutier, Van Roost, Colau, Renauld: "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 18, pp. 10144-9, 2000

Ozaki, Kikly, Michalovich, Young, Leonard: "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 21, pp. 11439-44, 2000

Images

Product Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Application Details Handling References for anti-IL21 Receptor Antibody (ABIN2658206) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-IL21 Receptor antibody (Interleukin 21 Receptor)  (APC) (ABIN2658206) anti-Interleukin 21 Receptor (IL21R) antibody (APC)
Flow Cytometry (FACS) image for anti-IL21 Receptor antibody (Interleukin 21 Receptor)  (APC) (ABIN2658206) anti-Interleukin 21 Receptor (IL21R) antibody (APC) (Image 2)