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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||47 Antibodies||19 Antibodies||15 Antibodies|
|Mass Cytometry (CyTOF)||1 Antibodies|
|Immunoprecipitation (IP)||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||11 Antibodies||7 Antibodies||6 Antibodies|
|Immunohistochemistry (IHC)||15 Antibodies||11 Antibodies||6 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies||11 Antibodies||11 Antibodies|
|Immunofluorescence (IF)||1 Antibodies||2 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Antigen||Interleukin 21 Receptor (IL21R) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This IL21 Receptor antibody is un-conjugated Alternatives|
ELISA, Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-IL21 Receptor AntibodyTarget Details IL21 Receptor Application Details Handling References for anti-IL21 Receptor Antibody (ABIN1002624) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN1004147|
|Purification||Affinity chromatography purified via peptide column.|
|Immunogen||Rabbit polyclol IL-21R antibody was raised against a synthetic peptide (CPDLVCYTDYLQT) corresponding to amino acids 20 to 32 of human IL-21R precursor .|
Target Details IL21 ReceptorProduct Details anti-IL21 Receptor Antibody Application Details Handling References for anti-IL21 Receptor Antibody (ABIN1002624) Images back to top
|Alternative Name||Interleukin 21 Receptor (IL21R Antibody Abstract)|
|Background||A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21 . The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling. Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.|
Application DetailsProduct Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Handling References for anti-IL21 Receptor Antibody (ABIN1002624) Images back to top
|Application Notes||IL-21 receptor antibody can be used for detection of IL-21 receptor by Western blot at 0.5 to 1 µg/ml. (Optimal dilution should be determined by user.) An approximately 60 kDa band can be detected. Antibody can also be used for ELISA and might be suited for other applications not tested so far.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Application Details References for anti-IL21 Receptor Antibody (ABIN1002624) Images back to top
|Buffer||Antibody is supplied in PBS containing 0.02% sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.|
|Expiry Date||12 months|
References for anti-IL21 Receptor Antibody (ABIN1002624)Product Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Application Details Handling Images back to top
|Product cited in:||
Asao, Okuyama, Kumaki et al.: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, 2001 (PubMed).
Vosshenrich, Di Santo: "Cytokines: IL-21 joins the gamma(c)-dependent network?" in: Current biology : CB, Vol. 11, Issue 5, pp. R175-7, 2001 (PubMed).
Parrish-Novak, Dillon, Nelson et al.: "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. ..." in: Nature, Vol. 408, Issue 6808, pp. 57-63, 2000 (PubMed).
Ozaki, Kikly, Michalovich et al.: "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 21, pp. 11439-44, 2000 (PubMed).