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Down-regulation of gamma(c) during early HIV/SIV infection may inhibit T-cell function, particularly of CD8 (show CD8A ELISA Kits)(+) T cells, and, may be linked with immune failure and loss of viral containment.
this study shows that downregulation of miR (show MLXIP ELISA Kits)-3940-5p promotes T-cell activity by targeting the cytokine receptor (show EBI3 ELISA Kits) IL-2R gamma on human cutaneous T-cell lines
Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2 (show IL2 ELISA Kits)- and IL-15 (show IL15 ELISA Kits)-activated T-cells has been reported.
systematic scoping review highlights the many potential uses of soluble interleukin-2 (show IL2 ELISA Kits) receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.
analysis of the contribution of IL2Rgamma to the dynamic formation of IL2 (show IL2 ELISA Kits)-IL2R (show IL2RA ELISA Kits) complexes
A deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency (show PRKDC ELISA Kits) with an atypical phenotype
novel missense mutation in Japanese patient results in atypical X-linked severe combined immunodeficiency (show PRKDC ELISA Kits) with the presence of T cells and NK cells and revertant somatic mosaicism
reversion of mutation in common lymphoid progenitor results in mild phenotype of SCID (show PRKDC ELISA Kits)
High IL2RG expression is associated with Sezary syndrome.
Identification of a gammaC splice isoform revealed expression of soluble gammaC proteins (sgammaC). sgammaC directly interacted with surface IL-2Rbeta (show IL2RB ELISA Kits) to suppress IL-2 (show IL2 ELISA Kits) signaling and to promote pro-inflammatory Th17 cell differentiation. [review]
Study show the detection of IL2RG mutations in 2 families with X-SCID (show PRKDC ELISA Kits) and identified 2 novel mutations, confirming the X-SCID (show PRKDC ELISA Kits) pedigrees.
Suggest that soluble common gamma chain may be one of the target molecules for the control of immunopathogenic progresses in COPD (show ARCN1 ELISA Kits).
Results indicate that conjugated-interleukin-2 (IL2 (show IL2 ELISA Kits)) protein derived from NKTR (show NKTR ELISA Kits)-214 occupy interleukin-2 (IL2 (show IL2 ELISA Kits)) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 (show IL2 ELISA Kits) protein.
Renal lesions are indeed modulated by intrinsic glomerular cells through the gamma-C/IL-2 (show IL2 ELISA Kits)-beta receptor response, to date classically described only in immune cells.
degree to which immune rejection contributes to these disappointing outcomes using an immunodeficient IL2 receptor gamma (IL2rgamma)-null mouse model, was examined.
We have confirmed the activation of human peripheral blood lymphocytes after being xenografted in immunodeficient Rag2 (show RAG2 ELISA Kits)-/-IL2Rgnull mice.
Results demonstrate that IL2Rgamma has an onogenic role in JAK3 (show JAK3 ELISA Kits)-mutation-positive leukemias.
findings demonstrate that NOD SCID (show PRKDC ELISA Kits) IL2R (show IL2RA ELISA Kits) common gamma chain -/- mice are capable of engraftment of canine PBLs yet develop graft versus host disease similar to Hu-PBL-SCID (show PRKDC ELISA Kits) mice
Interleukin-2 (show IL2 ELISA Kits) signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor.
gammac expression was required to signal the differentiation of MHC class I-specific thymocytes into CD8 (show CD8A ELISA Kits)+ cytotoxic lineage T cells and into invariant natural killer T cells.
analysis of multiorgan metastasis of human HER-2 (show ERBB2 ELISA Kits)+ breast cancer in Rag2 (show RAG2 ELISA Kits)-/-;Il2rg-/- mice and treatment with PI3K inhibitor
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
cytokine receptor common subunit gamma
, interleukin 2 receptor gamma
, interleukin 2 receptor, gamma (severe combined immunodeficiency)
, membrane receptor Il2rg
, interleukin 2 receptor, gamma
, CD132 antigen
, IL-2 receptor subunit gamma
, IL-2R subunit gamma
, common cytokine receptor gamma chain
, IL-2R gamma chain
, cytokine receptor common gamma chain
, interleukin-2 receptor gamma chain
, interleukin-2 receptor subunit gamma
, interleukin 2 receptor gamma chain
, common gamma chain
, gamma C receptor