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|Antigen||Interleukin 7 Receptor (IL7R) Antibodies|
|Epitope||Extracellular Domain Alternatives|
|Conjugate||This IL7R antibody is un-conjugated Alternatives|
Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Western Blotting (WB)
|5 references available|
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Product Details anti-IL7R AntibodyTarget Details IL7R Application Details Handling References for anti-IL7R antibody (ABIN4900541) Images
|Specificity||Detects human IL-7 R alpha in Western blots. In Western blots, approximately 5 % cross-reactivity was observed with recombinant human (rh) IL-10 R, rhIL-2 R beta , rhIL-5 R alpha , and rhIL-6 R.|
|Purification||Protein A or G purified from ascites|
|Sterility||0.2 μm filtered|
|Immunogen||Mouse myeloma cell line NS0-derived recombinant human IL-7 R alpha , Extracellular domain|
Target Details IL7RProduct Details anti-IL7R Antibody Application Details Handling References for anti-IL7R antibody (ABIN4900541) Images back to top
|Alternative Name||IL-7 R alpha/cd127 (IL7R Antibody Abstract)|
|Background||Alternative Names: CD127, CD127 antigen, CD127ILRA, CDW127, IL-7 receptor subunit alpha, IL7R, IL7R alpha, IL-7R subunit alpha, IL7RA, IL-7RA, IL-7R-alpha, interleukin 7 receptor, interleukin 7 receptor alpha chain, interleukin 7 receptor isoform H5-6, interleukin-7 receptor subunit alpha|
|Pathways||JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size|
Application DetailsProduct Details anti-IL7R Antibody Target Details IL7R Handling References for anti-IL7R antibody (ABIN4900541) Images back to top
Western Blot 1 μg/mL
Flow Cytometry 2.5 μg/10^6 cells
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL7R Antibody Target Details IL7R Application Details References for anti-IL7R antibody (ABIN4900541) Images back to top
|Reconstitution||Reconstitute at 0.5 mg/mL in sterile PBS.|
|Buffer||Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.|
|Storage||4 °C,-20 °C,-80 °C|
|Storage Comment||Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.|
|Expiry Date||12 months|
References for anti-IL7R antibody (ABIN4900541)Product Details anti-IL7R Antibody Target Details IL7R Application Details Handling Images back to top
|Product cited in:||
Kreft, Verbraak, Wierenga-Wolf, van Meurs, Oostra, Laman, Hintzen: "Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients." in: Genes and immunity, Vol. 13, Issue 7, pp. 587-92, 2012 Method employed by authors: ELISA (ELISA) (Sample species: Human).
Hoe, McKay, Schibeci, Gandhi, Heard, Stewart, Booth: "Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 5, pp. 2512-7, 2010 Method employed by authors: ELISA (ELISA) (Sample species: Human).
Rose, Pillet, Lavergne, Tamarit, Lenormand, Rousselle, Namane, Thèze: "Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response." in: The Journal of biological chemistry, Vol. 285, Issue 20, pp. 14898-908, 2010 Method employed by authors: Immunoprecipitation (IP) (Sample species: Human).
Rose, Lambotte, Pallier, Delfraissy, Colle: "Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 12, pp. 7389-97, 2009 Method employed by authors: ELISA (ELISA) (Sample species: Human).
Srivastava, Srivastava: "Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma." in: Leukemia research, Vol. 29, Issue 7, pp. 771-83, 2005 Method employed by authors: Immunocytochemistry (ICC) (Sample species: Human).
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