anti-Mouse (Murine) IL7R antibody for Immunoprecipitation

Recommended IL7R Antibody (supplied by: Log in to see )

Antigen
Interleukin 7 Receptor (IL7R) Antibodies
  • IL7R
  • CD127
  • IL-7Ralpha
  • CDW127
  • IL-7R-alpha
  • IL7RA
  • ILRA
  • IL-7RA
  • interleukin 7 receptor
  • IL7R
  • LOC100226205
  • Il7r
Epitope
pTyr449
31
29
26
18
15
15
13
10
7
7
6
5
5
5
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
253
239
41
3
2
1
1
Host
Rabbit
147
136
129
21
7
6
Clonality
Polyclonal
Conjugate
This IL7R antibody is un-conjugated
30
29
26
22
18
18
13
13
10
9
9
8
7
7
7
7
6
5
5
5
5
5
5
5
4
2
2
2
2
2
2
2
2
1
1
1
1
Application
Immunoprecipitation (IP), ELISA, Western Blotting (WB)
232
190
73
67
49
26
18
14
12
11
7
5
4
4
3
3
2
2
2
1
1
1
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Catalog No. ABIN233847
$ 379.00
Plus shipping costs $45.00 and $21.00 dry ice
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1176855 BR FACS IP IHC WB Rat IgG2a, kappa Log in to see SB-14 9
1 ABIN2660810 BR FACS IP IHC Biotin Rat IgG2a kappa Log in to see A7R34 5
1 ABIN259910 ELISA IHC IP WB Rabbit pTyr449 Log in to see Polyclonal
1 ABIN1175191 ICC IHC IP WB Rabbit IgG AA 48-217 Log in to see Polyclonal
1 ABIN2660809 BR FACS IP IHC Biotin Rat IgG2a kappa Log in to see A7R34 5
1 ABIN2567190 Func FACS IP IHC Rat IgG2a kappa Log in to see A7R34
1 ABIN5507568 ELISA IP WB Rabbit IgG AA 1-239 Log in to see Polyclonal

General

Antigen Interleukin 7 Receptor (IL7R) Antibodies
Epitope pTyr449
(31), (29), (26), (18), (15), (15), (13), (10), (7), (7), (6), (5), (5), (5), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Mouse (Murine)
(253), (239), (41), (3), (2), (1), (1)
Host Rabbit
(147), (136), (129), (21), (7), (6)
Clonality
Polyclonal
Conjugate This IL7R antibody is un-conjugated
(30), (29), (26), (22), (18), (18), (13), (13), (10), (9), (9), (8), (7), (7), (7), (7), (6), (5), (5), (5), (5), (5), (5), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application Immunoprecipitation (IP), ELISA, Western Blotting (WB)
(232), (190), (73), (67), (49), (26), (18), (14), (12), (11), (7), (5), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-IL7R Antibody

Target Details IL7R Application Details Handling References for anti-IL7R antibody (ABIN233847) Images
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics Concentration Definition: by UV absorbance at 280 nm
Immunogen This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to residues near Y449 of mouse IL-7 protein.
Isotype IgG

Target Details IL7R

Product Details anti-IL7R Antibody Application Details Handling References for anti-IL7R antibody (ABIN233847) Images back to top
Antigen
Alternative Name IL-7 Receptor Alpha Chain (IL7R Antibody Abstract)
Background This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules.  The human and mouse sequence is nearly identical.  In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged. IL-7 Receptor Alpha Chain phospho Y449 Antibody is ideal for investigators involved in Cell Signaling, Signal Transduction and Immunology research.
Synonyms: IL7Ralpha antibody, Interleukin 7 receptor alpha chain antibody, Interleukin 7 receptor antibody
Gene ID 16197, 45269152
UniProt P16872
Pathways JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size

Application Details

Product Details anti-IL7R Antibody Target Details IL7R Handling References for anti-IL7R antibody (ABIN233847) Images back to top
Application Notes This affinity purified antibody has been tested for use in ELISA, immunoprecipitation, and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 55 kDa in size corresponding to phosphorylated IL-7 by western blotting in the appropriate cell lysate or extract.  This phospho-specific polyclonal antibody reacts with mouse IL-7 pY449 and shows minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide.
Restrictions For Research Use only

Handling

Product Details anti-IL7R Antibody Target Details IL7R Application Details References for anti-IL7R antibody (ABIN233847) Images back to top
Format Liquid
Concentration 0.82 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C

References for anti-IL7R antibody (ABIN233847)

Product Details anti-IL7R Antibody Target Details IL7R Application Details Handling Images back to top
Product cited in:

Osborne, Dhanji, Snow, Priatel, Ma, Miners, Teh, Goldsmith, Abraham: "Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice." in: The Journal of experimental medicine, Vol. 204, Issue 3, pp. 619-31, 2007

Images

Product Details anti-IL7R Antibody Target Details IL7R Application Details Handling References for anti-IL7R antibody (ABIN233847) back to top
Supplier Images
Western Blotting (WB) image for anti-Interleukin 7 Receptor (IL7R) (pTyr449) antibody (ABIN233847) Western Blot and immunoprecipitation of Rabbit anti- IL-7-Receptor-alpha-chain-pY449 ...
 image for anti-Interleukin 7 Receptor (IL7R) (pTyr449) antibody (ABIN233847) anti-Interleukin 7 Receptor (IL7R) (pTyr449) antibody (Image 2)