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anti-Human Leptin Receptor antibody for Immunohistochemistry (Frozen Sections)

Recommended Leptin Receptor Antibody (supplied by: Log in to see )

Antigen
Leptin Receptor (LEPR) Antibodies
  • obr
  • cd295
  • ob-rb
  • CD295
  • LEP-R
  • LEPRD
  • OB-R
  • OBR
  • ObRb
  • LEPROT
  • Leprb
  • Modb1
  • OB-RGRP
  • Obr
  • db
  • diabetes
  • obese-like
  • obl
  • Ob-R
  • Ob-RM
  • Fa
  • LEPR
  • Obrgrp
  • VPS55
  • leptin receptor
  • leptin receptor overlapping transcript
  • Leptin receptor-like
  • leptin receptor-like
  • lepr
  • LEPR
  • Lepr
  • Leprot
  • LOC100351924
  • LOC100069504
Epitope
Extracellular Domain
23
22
22
17
14
13
13
6
5
4
4
4
4
4
4
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
198
65
54
13
8
2
1
1
1
1
1
Host
Mouse
141
45
30
3
2
1
Clonality
Monoclonal
Conjugate
This Leptin Receptor antibody is un-conjugated
10
9
8
7
6
5
4
4
4
4
3
3
3
3
3
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
136
106
53
35
34
30
6
6
4
2
1
Supplier
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Catalog No. ABIN114692
$ 478.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN114694 EIA IHC (fro) WB Mouse IgG1 N-Term, C-Term, Extracellular Domain Log in to see LPR-01 1
1 ABIN1106239 EIA IHC (fro) IHC (p) WB Mouse IgG1 Soluble Log in to see 2F1 1
1 ABIN1859649 ICC IHC (fro) IHC (p) ELISA WB Rabbit IgG AA 310-538 Log in to see Polyclonal
1 ABIN609033 IHC (fro) IHC (p) WB Mouse IgG1 Log in to see

Top referenced anti-Leptin Receptor antibody for Immunohistochemistry (Frozen Sections)

Similar anti-Leptin Receptor Antibodies

Application / Reactivity Human
ELISA 96 Antibodies
Enzyme Immunoassay (EIA) 7 Antibodies
Flow Cytometry (FACS) 28 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 34 Antibodies
Immunohistochemistry (IHC) 48 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 5 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 31 Antibodies
Western Blotting (WB) 119 Antibodies

General

Antigen Leptin Receptor (LEPR) Antibodies
Epitope Extracellular Domain
(23), (22), (22), (17), (14), (13), (13), (6), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(198), (65), (54), (13), (8), (2), (1), (1), (1), (1), (1)
Host Mouse
(141), (45), (30), (3), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Leptin Receptor antibody is un-conjugated
(10), (9), (8), (7), (6), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(136), (106), (53), (35), (34), (30), (6), (6), (4), (2), (1)
Pubmed 1 reference available
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Product Details anti-Leptin Receptor Antibody

Target Details Leptin Receptor Application Details Handling References for anti-Leptin Receptor Antibody (ABIN114692) Images
Purification Affinity chromatography on Protein G
Immunogen The Human Leptin Receptor is a recombinant protein produced in mouse myeloma cell line. DNA sequence including the extracellular domain of Leptin Receptor (amino acid residues 1 839) fused to the Fc region of human IgG (with IIEGR added at the amino terminus and 6 histidine residues added at the carboxy terminus).
Clone LPR-02
Isotype IgG1

Target Details Leptin Receptor

Product Details anti-Leptin Receptor Antibody Application Details Handling References for anti-Leptin Receptor Antibody (ABIN114692) Images back to top
Antigen
Alternative Name CD295 / Leptin Receptor (LEPR Antibody Abstract)
Background Leptin receptor (OB R) was identified as a leptin binding protein (Leptin, the product of the ob gene, is a single chain 16 kDa protein consisting of 146 amino acid residues.) OB R was found to be a member of the class I cytokine receptor family with a large extracellular domain comprising 816 amino acid residues. Leptin receptor exists in multiple forms with a common extracellular domain and a variable length cytoplasmatic portion. Alternate splicing from a single gene derives the six isoforms of the Leptin receptor. The soluble form of the Leptin receptor, OB R contains no intracellular motifs or transmembrane residues, thus it consists entirely of the extracellular ligand binding domain of the receptor. Long forms of OB-R transcripts were reported to be expressed predominantly in regions of the hypothalamus which provides evidence that Leptin receptor is important in body weight regulation. Expression of short forms of OB-R transcripts have been found in multiple tissues, including the choroid plexus, lung, kidney, and primitive hematopoietic cell populations. Leptin receptor may act as a negative regulator of Leptin activity and it may maintain a pool of available bioactive Leptin by binding and delaying its clearance from circulation. Soluble Leptin receptor levels are indirectly proportional to adiposity and are increased in females versus males. Leptin receptor levels are highest in infants, decrease into adolescence, and remain relatively stable throughout adulthood. Soluble Leptin receptor is also found upregulated in patients with chronic heart failure, end-stage renal disease and anorexia.Synonyms: DB, HuB219, LEP-R, LEPR, OB receptor, OB-R, OBR
Gene ID 9606
UniProt P48357
Research Area Hormones, Receptors
Pathways JAK-STAT Signaling, AMPK Signaling

Application Details

Product Details anti-Leptin Receptor Antibody Target Details Leptin Receptor Handling References for anti-Leptin Receptor Antibody (ABIN114692) Images back to top
Application Notes ELISA. Immunohistochemistry. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-Leptin Receptor Antibody Target Details Leptin Receptor Application Details References for anti-Leptin Receptor Antibody (ABIN114692) Images back to top
Reconstitution Restore with 0.1 mL of deionized water.
Concentration 1.0 mg/mL
Buffer 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.
Expiry Date 6 months

References for anti-Leptin Receptor Antibody (ABIN114692)

Product Details anti-Leptin Receptor Antibody Target Details Leptin Receptor Application Details Handling Images back to top
Background publications

Verhaeghe, van Bree, Van Herck: "Maternal body size and birth weight: can insulin or adipokines do better?" in: Metabolism: clinical and experimental, Vol. 55, Issue 3, pp. 339-44, 2006