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anti-Human MPL antibody for Enzyme Immunoassay

Recommended MPL Antibody (supplied by: Log in to see )

Antigen
Myeloproliferative Leukemia Virus Oncogene (MPL) Antibodies
  • C-MPL
  • c-mpl
  • c-mpl-I
  • c-mpl-II
  • CD110
  • hlb219
  • MPL
  • MPLV
  • THCYT2
  • TPO-R
  • TPOR
Reactivity
Human
51
33
28
Host
Mouse
45
10
Clonality
Monoclonal
Conjugate
This MPL antibody is un-conjugated
4
4
3
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
27
22
12
10
8
3
2
2
2
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Catalog No. ABIN1105749
$ 423.50
Plus shipping costs $45.00

Top referenced anti-MPL antibody for Enzyme Immunoassay

Similar anti-MPL Antibodies

Application / Reactivity Human
ELISA 9 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies
Flow Cytometry (FACS) 11 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 22 Antibodies
Immunohistochemistry (IHC) 2 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 7 Antibodies
Immunoprecipitation (IP) 3 Antibodies
Western Blotting (WB) 25 Antibodies

General

Antigen Myeloproliferative Leukemia Virus Oncogene (MPL) Antibodies
Reactivity Human
(51), (33), (28)
Host Mouse
(45), (10)
Clonality (Clone)
Monoclonal   ( )
Conjugate This MPL antibody is un-conjugated
(4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
(27), (22), (12), (10), (8), (3), (2), (2), (2)
Pubmed 2 references available
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Product Details anti-MPL Antibody

Target Details MPL Application Details Handling References for anti-MPL Antibody (ABIN1105749) Images
Specificity Recognizes MPL/CD110
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Purified
Clone 1H2
Isotype IgG2b

Target Details MPL

Product Details anti-MPL Antibody Application Details Handling References for anti-MPL Antibody (ABIN1105749) Images back to top
Antigen
Alternative Name CD110 (MPL Antibody Abstract)
Background In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.Synonyms: MPL, Myeloproliferative leukemia protein, TPO-R, TPOR
Molecular Weight 71.2 kDa
Gene ID 4352
Pathways JAK-STAT Signaling

Application Details

Product Details anti-MPL Antibody Target Details MPL Handling References for anti-MPL Antibody (ABIN1105749) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-MPL Antibody Target Details MPL Application Details References for anti-MPL Antibody (ABIN1105749) Images back to top
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, 0.05 % Sodium Azide, 0.5 % protein stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

References for anti-MPL Antibody (ABIN1105749)

Product Details anti-MPL Antibody Target Details MPL Application Details Handling Images back to top
Background publications

Marty, Chaligné, Lacout, Constantinescu, Vainchenker, Villeval: "Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 11781-91, 2009

Raposo, Sousa, Kirsch, Cardoso, Belsley, de Matos Gomes, Fonseca: "Synthesis and characterization of dicyanovinyl-substituted thienylpyrroles as new nonlinear optical chromophores." in: Organic letters, Vol. 8, Issue 17, pp. 3681-4, 2006

Images

Product Details anti-MPL Antibody Target Details MPL Application Details Handling References for anti-MPL Antibody (ABIN1105749) back to top
Supplier Images
Western Blotting (WB) image for anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) (ABIN1105749) anti-Myeloproliferative Leukemia Virus Oncogene (MPL) antibody
Flow Cytometry (FACS) image for anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) (ABIN1105749) anti-Myeloproliferative Leukemia Virus Oncogene (MPL) antibody (Image 2)
ELISA image for anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) (ABIN1105749) anti-Myeloproliferative Leukemia Virus Oncogene (MPL) antibody (Image 3)