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MPL antibody
MPL
Reactivity: Mouse, Rat
IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-MPL Antibody
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Target
See all MPL Antibodies
MPL
(Myeloproliferative Leukemia Virus Oncogene (MPL))
Reactivity
All reactivities for MPL antibodies
Mouse, Rat
Host
All hosts for MPL antibodies
Rabbit
Clonality
All clonalities for MPL antibodies
Polyclonal
Conjugate
All conjugates for MPL antibodies
This MPL antibody is un-conjugated
Application
All applications for MPL antibodies
Immunohistochemistry (IHC), Immunofluorescence (IF)
Cross-Reactivity
Rat
Purification
Affinity purification
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse TPOR
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Discover our top product MPL Primary Antibody
Alternatives
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Application Details
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Application Notes
IHC/IF (M,R) 1:500-1:2000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS, pH 7.4, 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Target Details for MPL
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Target
MPL
(Myeloproliferative Leukemia Virus Oncogene (MPL))
Alternative Name
TPOR/MPL (MPL Products )
Synonyms
C-MPL antibody, CD110 antibody, MPLV antibody, THCYT2 antibody, TPOR antibody, TPO-R antibody, c-mpl antibody, c-mpl-I antibody, c-mpl-II antibody, hlb219 antibody, MPL antibody, mpll antibody, tpor antibody, tpor.b antibody, MPL proto-oncogene, thrombopoietin receptor antibody, myeloproliferative leukemia virus oncogene antibody, MPL antibody, Mpl antibody, mpl antibody
Background
The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Gene ID
17480
NCBI Accession
NP_001116421
UniProt
Q08351
Pathways
JAK-STAT Signaling
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