anti-Human STAT4 antibody for Intracellular Staining

Recommended STAT4 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 4 (STAT4) Antibodies
  • SLEB11
  • signal transducer and activator of transcription 4
  • STAT4
  • stat4
  • Stat4
Epitope
pTyr693
73
25
11
10
9
8
7
7
6
6
5
4
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
282
118
101
11
10
8
6
5
4
2
1
1
Host
Mouse
189
70
30
2
2
Clonality
Monoclonal
Conjugate
This STAT4 antibody is conjugated to PE
10
10
8
7
6
6
4
3
2
2
2
2
2
2
2
2
2
Application
Intracellular Staining (ICS)
219
105
86
50
47
37
26
24
6
4
3
3
3
2
1
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Available images

Catalog No. ABIN1177204
Contact our Customer Service for availability and price in your country.
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1177205 ICS Alexa Fluor 647 Mouse IgG2b, kappa pTyr693 Log in to see 38-p 2
1 ABIN1177203 ICS Alexa Fluor 647 Mouse IgG2b, kappa pTyr693 Log in to see 38-p 2
1 ABIN1177202 ICS PE Mouse IgG2b, kappa pTyr693 Log in to see 38-p 2
1 ABIN1177206 ICS Alexa Fluor 488 Mouse IgG2b, kappa pTyr693 Log in to see 38-p

General

Antigen Signal Transducer and Activator of Transcription 4 (STAT4) Antibodies
Epitope pTyr693
(73), (25), (11), (10), (9), (8), (7), (7), (6), (6), (5), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(282), (118), (101), (11), (10), (8), (6), (5), (4), (2), (1), (1)
Host Mouse
(189), (70), (30), (2), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This STAT4 antibody is conjugated to PE
(10), (10), (8), (7), (6), (6), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Intracellular Staining (ICS)
(219), (105), (86), (50), (47), (37), (26), (24), (6), (4), (3), (3), (3), (2), (1), (1), (1)
Pubmed 2 references available
Supplier Log in to see

Product Details anti-STAT4 Antibody

Target Details STAT4 Application Details Handling ProductDetails: References for anti-STAT4 antibody (ABIN1177204) Images
Brand BD Phosflow™
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Phosphorylated Human Stat4 (pY693)
Clone 38-p
Isotype IgG2b, kappa

Target Details STAT4

Product Details anti-STAT4 Antibody Application Details Handling ProductDetails: References for anti-STAT4 antibody (ABIN1177204) Images back to top
Antigen
Alternative Name Stat4 (STAT4 Antibody Abstract)
Background The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Seven mammalian Stat proteins have been identified: Stat1-4, Stat5a, 5b, and Stat6. Stat4 has been shown to play an important role in development of T helper cells, specifically the Th1 subset. Stat4 is activated by IL-12 and by type 1 interferons. Knockout mice supported the role that Stat4 plays in IL-12 signaling because lymphocytes from Stat 4-/- mice could not differentiate into Th1 cells or produce IFNgamma in response to treatment with IL-12. IFNgamma plays an important role in host defense. A key component in the activation of Stat4 is the phosphorylation on tyrosine and serine residues in response to IL-12 stimulation. IL-12 stimulation leads to the phosphorylation of Stat4 on tyrosine 693 and serine 721. Transcriptional activity of Stat4 has been shown to be significantly reduced when residues Y693 and S721 are mutated.
Research Area Inflammation
Pathways JAK-STAT Signaling

Application Details

Product Details anti-STAT4 Antibody Target Details STAT4 Handling ProductDetails: References for anti-STAT4 antibody (ABIN1177204) Images back to top
Sample Volume 20 μL
Restrictions For Research Use only

Handling

Product Details anti-STAT4 Antibody Target Details STAT4 Application Details ProductDetails: References for anti-STAT4 antibody (ABIN1177204) Images back to top
Format Liquid
Buffer Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.

ProductDetails: References for anti-STAT4 antibody (ABIN1177204)

Product Details anti-STAT4 Antibody Target Details STAT4 Application Details Handling Images back to top
Product cited in:

Kisseleva, Bhattacharya, Braunstein, Schindler: "Signaling through the JAK/STAT pathway, recent advances and future challenges." in: Gene, Vol. 285, Issue 1-2, pp. 1-24, 2002

Visconti, Gadina, Chiariello, Chen, Stancato, Gutkind, OShea: "Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity." in: Blood, Vol. 96, Issue 5, pp. 1844-52, 2000

Images

Product Details anti-STAT4 Antibody Target Details STAT4 Application Details Handling ProductDetails: References for anti-STAT4 antibody (ABIN1177204) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Signal Transducer and Activator of Transcription 4 (STAT4) (pTyr693) antibody (PE) (ABIN1177204) anti-Signal Transducer and Activator of Transcription 4 (STAT4) (pTyr693) antibody (PE)