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anti-Mouse (Murine) STAT4 antibody for Flow Cytometry

Recommended STAT4 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 4 (STAT4) Antibodies
  • SLEB11
Reactivity
Human, Mouse (Murine)
267
101
79
8
8
4
3
2
2
2
1
Host
Mouse
181
67
28
2
2
Clonality
Monoclonal
Conjugate
This STAT4 antibody is un-conjugated
9
9
8
8
6
6
4
4
3
2
2
2
2
2
2
Application
Flow Cytometry (FACS)
201
105
82
47
37
35
24
22
6
5
4
4
2
2
1
Supplier
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Catalog No. ABIN2665369
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Top referenced anti-STAT4 antibody for Flow Cytometry

Similar anti-STAT4 Antibodies

Application / Reactivity Human Mouse (Murine)
Western Blotting (WB) 188 Antibodies 70 Antibodies
Luminex Assay (LMNX) 6 Antibodies
Intracellular Staining (ICS) 5 Antibodies 3 Antibodies
Immunoprecipitation (IP) 27 Antibodies 21 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 37 Antibodies 12 Antibodies
Immunohistochemistry (IHC) 105 Antibodies 37 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 24 Antibodies 24 Antibodies
Immunofluorescence (IF) 46 Antibodies 5 Antibodies
Immunocytochemistry (ICC) 4 Antibodies 1 Antibodies
Immunochromatography (IC) 1 Antibodies

General

Antigen Signal Transducer and Activator of Transcription 4 (STAT4) Antibodies
Reactivity Human, Mouse (Murine)
(267), (101), (79), (8), (8), (4), (3), (2), (2), (2), (1)
Host Mouse
(181), (67), (28), (2), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This STAT4 antibody is un-conjugated
(9), (9), (8), (8), (6), (6), (4), (4), (3), (2), (2), (2), (2), (2), (2)
Application Flow Cytometry (FACS)
(201), (105), (82), (47), (37), (35), (24), (22), (6), (5), (4), (4), (2), (2), (1)
Pubmed 4 references available
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Product Details anti-STAT4 Antibody

Target Details STAT4 Application Details Handling References for anti-STAT4 Antibody (ABIN2665369) Images
Purification The antibody was purified by affinity chromatography.
Clone 15A1B41
Isotype IgG2b kappa

Target Details STAT4

Product Details anti-STAT4 Antibody Application Details Handling References for anti-STAT4 Antibody (ABIN2665369) Images back to top
Antigen
Alternative Name STAT4 (STAT4 Antibody Abstract)
Background STAT4 is a member of the signal transducer and activator of transcription factors (STAT) family, transducing signals induced by IL-12, IL-23, and IFN-γ stimulation in T cells and monocytes. Upon activation, STAT4 is phosphorylated by receptor-associated JAK kinases, homodimerized through its SH2 domain, translocated to the nucleus and, in turn, transactivates target genes. Activation of STAT4 leads to production of IFN-γ and differentiation of Th1 and Th17 cells. STAT4 deficient mice exhibit impaired Th1 responses and abrogation of cytocytic functions of T and NK cells, suggesting STAT4 is critical in cell-mediated immune responses. Single nucleotide polymorphisms (SNPs) in the STAT4 gene have been shown to correlate with susceptibility to autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling

Application Details

Product Details anti-STAT4 Antibody Target Details STAT4 Handling References for anti-STAT4 Antibody (ABIN2665369) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-STAT4 Antibody Target Details STAT4 Application Details References for anti-STAT4 Antibody (ABIN2665369) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-STAT4 Antibody (ABIN2665369)

Product Details anti-STAT4 Antibody Target Details STAT4 Application Details Handling Images back to top
Background publications

Huang, Lei, Zhang, Hou, Zhang, Dayton: "MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of IL-12 signaling in human natural killer cells." in: Blood, Vol. 118, Issue 26, pp. 6793-802, 2011

Good, Thieu, Mathur, Yu, Stritesky, Yeh, OMalley, Perumal, Kaplan: "Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 6, pp. 3839-47, 2009

OMalley, Eri, Stritesky, Mathur, Chang, Hogenesch, Srinivasan, Kaplan: "STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 7, pp. 5062-70, 2008

Korman, Kastner, Gregersen, Remmers: "STAT4: genetics, mechanisms, and implications for autoimmunity." in: Current allergy and asthma reports, Vol. 8, Issue 5, pp. 398-403, 2008

Images

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Supplier Images
Immunofluorescence (IF) image for anti-STAT4 antibody (Signal Transducer and Activator of Transcription 4) (ABIN2665369) anti-Signal Transducer and Activator of Transcription 4 (STAT4) antibody
Western Blotting (WB) image for anti-STAT4 antibody (Signal Transducer and Activator of Transcription 4) (ABIN2665369) anti-Signal Transducer and Activator of Transcription 4 (STAT4) antibody (Image 2)