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M1 macrophages with inhibited STAT3 (show STAT3 Proteins), STAT6 and/or SMAD3 (show SMAD3 Proteins) effectively restrict tumor growth. The findings justify the development of new anti-tumor cell therapy technology.
cytokine-activated STAT3 and STAT6 cooperate in macrophages to promote a secretory phenotype that enhances tumor progression in a cathepsin-dependent manner.
these results demonstrate that a STAT6-dependent macrophage phenotype promotes mucosal repair in murine inflammatory bowel disease through activation of the Wnt (show WNT2 Proteins) signaling pathway
These data indicate a role for STAT3 (show STAT3 Proteins) in maintaining a steady state in the beta-cell, by modulating its cell cycle and protection from DNA damage.
STAT6 phosphorylation (p-STAT6) was significantly increased in TECs from both Grave's disease patients and experimental autoimmune Graves' disease mice.
this study shows that sodium benzoate induces the expression of TGF-beta (show TGFB1 Proteins) in splenocytes and alleviates experimental allergic encephalomyelitis via the STAT6-TGF-beta (show TGFB1 Proteins)-Treg pathway
this study shows that wild-type mice develop an eosinophilic Th2 airway disease in response to Alternaria alternata exposure, whereas STAT6-deficient mice exhibit a primarily neutrophilic response
this study shows that IL-17A (show IL17A Proteins) contributes to asthma pathophysiology by increasing the capacity of IL-13 (show IL13 Proteins) to activate intracellular signaling pathways, such as STAT6 activation
RCM-1 (show TNNI3 Proteins) reduced IL-13 (show IL13 Proteins) and STAT6 (signal transducer and activator of transcription 6) signaling and prevented the expression of the STAT6 target genes Spdef and Foxa3 (show FOXA3 Proteins), which are key transcriptional regulators of goblet cell differentiation.
These studies are the first to demonstrate that gammadelta17 cells express the type I IL-4 (show IL4 Proteins) receptor and that STAT6 signaling negatively regulates gammadelta17 cells, a cell population that plays a front-line role in mucosal immunity.
Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 target gene CCL18, while induction of other STAT6-inducible genes such as SPINT2 remained unaffected by JMJD3.
The results suggest that nuclear localization and cleavage of STAT6 is important for modulating the viral latency and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV).
the phosphorylation of signal transducer and activator of transcription 1 (STAT1 (show STAT1 Proteins)-py) was impaired in asthmatics, whereas the phosphorylation of signal transducer and activator of transcription 6 (STAT6-py) was slightly enhanced.
PVT1-derived miR (show MLXIP Proteins)-1207-5p promotes the proliferation of breast cancer cells by targeting STAT6.
STAT6 single-nucleotide polymorphism is associated with migraine.
Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2 (show NAB2 Proteins)-STAT6 fusion genes ,the molecular hallmark of solitary fibrous tumours.
STAT6 and ALDH1 immunohistochemistry can be used in the differential diagnosis of solitary fibrous tumor versus prostate-specific stromal neoplasms.
Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2 (show NAB2 Proteins)-STAT6 gene fusion as was nonmeningeal solitary fibrous tumor
STAT6-TMEM16A (show ANO1 Proteins)-ERK1/2 signal pathway and TMEM16A (show ANO1 Proteins) channel activity are required for the IL-13 (show IL13 Proteins)-induced TMEM16A (show ANO1 Proteins) mediated mucus production
this study shows that weaning caused severe inflammation associated with the suppression of STAT6 in the jejunum of piglets
Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak (show JAK3 Proteins)/STAT6 and phosphorylation and translocation of FoxO1 (show FOXO1 Proteins) from the nucleus to the cytoplasm.
Results provide evidence that polymorphisms in STAT6 are associated with carcass and growth efficiency traits
IL-4 (show IL4 Proteins) and STAT6 are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
signal transducer and transcription activator 6
, STAT, interleukin4-induced
, signal transducer and activator of transcription 6
, transcription factor IL-4 STAT