Browse our STAT6 Proteins (STAT6)

Full name:
Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced Proteins (STAT6)
On www.antibodies-online.com are 15 Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) Proteins from 8 different suppliers available. Additionally we are shipping STAT6 Antibodies (453) and STAT6 Kits (43) and many more products for this protein. A total of 527 STAT6 products are currently listed.
Synonyms:
D12S1644, IL-4-STAT, STAT6B, STAT6C
list all proteins Gene Name GeneID UniProt
STAT6 20852 P52633
STAT6 6778 P42226
STAT6 362896  

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STAT6 Proteins (STAT6) by Origin

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Top referenced STAT6 Proteins

  1. Human STAT6 Protein expressed in Baculovirus infected Insect Cells - ABIN2005539 : Litterst, Pfitzner: Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 references for 2005539

More Proteins for STAT6 Interaction Partners

Mouse (Murine) Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) interaction partners

  1. STAT6 phosphorylation (p-STAT6) was significantly increased in TECs from both Grave's disease patients and experimental autoimmune Graves' disease mice.

  2. this study shows that sodium benzoate induces the expression of TGF-beta (show TGFB1 Proteins) in splenocytes and alleviates experimental allergic encephalomyelitis via the STAT6-TGF-beta (show TGFB1 Proteins)-Treg pathway

  3. this study shows that wild-type mice develop an eosinophilic Th2 airway disease in response to Alternaria alternata exposure, whereas STAT6-deficient mice exhibit a primarily neutrophilic response

  4. this study shows that IL-17A (show IL17A Proteins) contributes to asthma pathophysiology by increasing the capacity of IL-13 (show IL13 Proteins) to activate intracellular signaling pathways, such as STAT6 activation

  5. RCM-1 (show TNNI3 Proteins) reduced IL-13 (show IL13 Proteins) and STAT6 (signal transducer and activator of transcription 6) signaling and prevented the expression of the STAT6 target genes Spdef and Foxa3 (show FOXA3 Proteins), which are key transcriptional regulators of goblet cell differentiation.

  6. These studies are the first to demonstrate that gammadelta17 cells express the type I IL-4 (show IL4 Proteins) receptor and that STAT6 signaling negatively regulates gammadelta17 cells, a cell population that plays a front-line role in mucosal immunity.

  7. this study identifies proteins in B cells that are regulated by IL-4 in a STAT6-dependent manner, which may contribute to germinal center formation and IgE switching in type 2 immunity

  8. Study showed that suppression of STAT3 (show STAT3 Proteins), STAT5 (show STAT5A Proteins), and STAT6 and overexpression of the proapoptotic factor STAT1 (show STAT1 Proteins), which provides p53 (show TP53 Proteins)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 (show ERBB2 Proteins) tyrosine kinase receptor (show KDR Proteins) overexpression promotes neuronal survival through activation of STAT (show STAT1 Proteins)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (show STAT1 Proteins)

  9. STAT6 mediates the CT-induced TIM4 (show TIMD4 Proteins) expression in DCs. In conclusion, p300 (show NOTCH1 Proteins) and STAT6 mediate the microbial product CT-induced TIM4 (show TIMD4 Proteins) expression in DCs.

  10. These data demonstrate that dysregulated IL-25 (show IL25 Proteins) expression contributes to lipid accumulation, whereas exogenous IL-25 (show IL25 Proteins) protects against hepatic steatosis through IL-13 (show IL13 Proteins) activation of STAT6.

Human Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) interaction partners

  1. STAT6 phosphorylation (p-STAT6) was significantly increased in TECs from both Grave's disease patients and experimental autoimmune Graves' disease mice.

  2. Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2 (show NAB2 Proteins)-STAT6 fusion genes ,the molecular hallmark of solitary fibrous tumours.

  3. STAT6 and ALDH1 (show ALDH1A1 Proteins) immunohistochemistry can be used in the differential diagnosis of solitary fibrous tumor versus prostate-specific (show KLK3 Proteins) stromal neoplasms.

  4. Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2 (show NAB2 Proteins)-STAT6 gene fusion as was nonmeningeal solitary fibrous tumor

  5. STAT6-TMEM16A (show ANO1 Proteins)-ERK1/2 signal pathway and TMEM16A (show ANO1 Proteins) channel activity are required for the IL-13 (show IL13 Proteins)-induced TMEM16A (show ANO1 Proteins) mediated mucus production

  6. The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2 (show NAB2 Proteins)-STAT6 fusion and helps to discriminate SFTs from histological mimics.

  7. The role of Th2 cytokines (IL-4 (show IL4 Proteins), IL-13 (show IL13 Proteins)) and STAT6 in Th1 (show TH1L Proteins)/Th2 imbalance.

  8. STAT6 gene (G2964) polymorphism may play a role in development of eczema among Saudi children

  9. Variants of the NAB2 (show NAB2 Proteins)-STAT6 fusion gene are found in solitary fibrous tumors of the meninges.

  10. the majority of intrathoracic SFTs exhibited STAT6 nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type.

Pig (Porcine) Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) interaction partners

  1. this study shows that weaning caused severe inflammation associated with the suppression of STAT6 in the jejunum of piglets

  2. Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak (show JAK3 Proteins)/STAT6 and phosphorylation and translocation of FoxO1 (show FOXO1 Proteins) from the nucleus to the cytoplasm.

Cow (Bovine) Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) interaction partners

  1. Results provide evidence that polymorphisms in STAT6 are associated with carcass and growth efficiency traits

Guinea Pig Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) interaction partners

  1. IL-4 (show IL4 Proteins) and STAT6 are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.

STAT6 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with STAT6

  • signal transducer and activator of transcription 6, interleukin-4 induced (STAT6)
  • signal transducer and activator of transcription 6 (Stat6)
  • signal transducer and activator of transcription 6-like (LOC100859543)
  • signal transducer and activator of transcription 6, interleukin-4 induced (Stat6)
  • D12S1644 protein
  • IL-4-STAT protein
  • STAT6B protein
  • STAT6C protein

Protein level used designations for STAT6

signal transducer and transcription activator 6 , STAT, interleukin4-induced , signal transducer and activator of transcription 6 , transcription factor IL-4 STAT

GENE ID SPECIES
100050053 Equus caballus
20852 Mus musculus
100859543 Gallus gallus
6778 Homo sapiens
100142679 Canis lupus familiaris
362896 Rattus norvegicus
100153518 Sus scrofa
353105 Bos taurus
100344264 Oryctolagus cuniculus
100726686 Cavia porcellus
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