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Human STAT6 Protein expressed in Baculovirus infected Insect Cells - ABIN2005539
Litterst, Pfitzner: Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. in The Journal of biological chemistry 2001
Show all 2 references for ABIN2005539
These studies are the first to demonstrate that gammadelta17 cells express the type I IL-4 (show IL4 Proteins) receptor and that STAT6 signaling negatively regulates gammadelta17 cells, a cell population that plays a front-line role in mucosal immunity.
this study identifies proteins in B cells that are regulated by IL-4 in a STAT6-dependent manner, which may contribute to germinal center formation and IgE switching in type 2 immunity
Study showed that suppression of STAT3 (show STAT3 Proteins), STAT5 (show STAT5A Proteins), and STAT6 and overexpression of the proapoptotic factor STAT1 (show STAT1 Proteins), which provides p53 (show TP53 Proteins)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 (show ERBB2 Proteins) tyrosine kinase receptor (show KDR Proteins) overexpression promotes neuronal survival through activation of STAT (show STAT1 Proteins)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (show STAT1 Proteins)
STAT6 mediates the CT-induced TIM4 (show TIMD4 Proteins) expression in DCs. In conclusion, p300 (show NOTCH1 Proteins) and STAT6 mediate the microbial product CT-induced TIM4 (show TIMD4 Proteins) expression in DCs.
These data demonstrate that dysregulated IL-25 (show IL25 Proteins) expression contributes to lipid accumulation, whereas exogenous IL-25 (show IL25 Proteins) protects against hepatic steatosis through IL-13 (show IL13 Proteins) activation of STAT6.
Grail (show RNF128 Proteins) interacts with Stat6 and targets it for ubiquitination and degradation in Th2 cells.
The lack of STAT6 did not affect the ability of macrophages to change cytokine production reciprocally or to rescue mice from lethal endotoxemia.
both in vivo and in vitro experiments demonstrate that the transcription factors STAT6 and KLF4 (show KLF4 Proteins) implement IL-4 (show IL4 Proteins)-induced M2 polarization via the dual catalytic activities of MCPIP (show ZC3H12A Proteins).
Th2 immunity mediated by STAT6 appears to play a protective role in a murine model of prurigo
Data suggest that transcription factor STAT6 regulates the recruitment of eosinophils to the lung during the development of allergic asthma.
STAT6-TMEM16A (show ANO1 Proteins)-ERK1/2 signal pathway and TMEM16A (show ANO1 Proteins) channel activity are required for the IL-13 (show IL13 Proteins)-induced TMEM16A (show ANO1 Proteins) mediated mucus production
The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2 (show NAB2 Proteins)-STAT6 fusion and helps to discriminate SFTs from histological mimics.
The role of Th2 cytokines (IL-4 (show IL4 Proteins), IL-13 (show IL13 Proteins)) and STAT6 in Th1 (show TH1L Proteins)/Th2 imbalance.
STAT6 gene (G2964) polymorphism may play a role in development of eczema among Saudi children
Variants of the NAB2 (show NAB2 Proteins)-STAT6 fusion gene are found in solitary fibrous tumors of the meninges.
the majority of intrathoracic SFTs exhibited STAT6 nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type.
Case Report: NAB2 (show NAB2 Proteins)-STAT6 fusion in glioblastoma.
A constitutively activated form of STAT6 is able to bypass IL-4 (show IL4 Proteins) upstream signalling and instruct dendritic-cell-specific functional DNA methylation (show HELLS Proteins) changes
interleukin-4 (show IL4 Proteins) regulates hematopoietic lineage choice by activating the JAK3 (show JAK3 Proteins)-STAT6 pathway, which causes dendritic-cell-specific DNA demethylation
Immunohistochemistry results indicate that combination with ALDH1 (show ALDH1A1 Proteins) and STAT6 can improve the diagnostic value of CD34 (show CD34 Proteins) for solitary fibrous tumors.
this study shows that weaning caused severe inflammation associated with the suppression of STAT6 in the jejunum of piglets
Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak (show JAK3 Proteins)/STAT6 and phosphorylation and translocation of FoxO1 (show FOXO1 Proteins) from the nucleus to the cytoplasm.
Results provide evidence that polymorphisms in STAT6 are associated with carcass and growth efficiency traits
IL-4 (show IL4 Proteins) and STAT6 are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
signal transducer and transcription activator 6
, STAT, interleukin4-induced
, signal transducer and activator of transcription 6
, transcription factor IL-4 STAT