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Human STAT6 Protein expressed in Baculovirus infected Insect Cells - ABIN2005539
Litterst, Pfitzner: Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. in The Journal of biological chemistry 2001
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These data demonstrate that dysregulated IL-25 (show IL25 Proteins) expression contributes to lipid accumulation, whereas exogenous IL-25 (show IL25 Proteins) protects against hepatic steatosis through IL-13 (show IL13 Proteins) activation of STAT6.
Grail (show RNF128 Proteins) interacts with Stat6 and targets it for ubiquitination and degradation in Th2 cells.
The lack of STAT6 did not affect the ability of macrophages to change cytokine production reciprocally or to rescue mice from lethal endotoxemia.
both in vivo and in vitro experiments demonstrate that the transcription factors STAT6 and KLF4 (show KLF4 Proteins) implement IL-4 (show IL4 Proteins)-induced M2 polarization via the dual catalytic activities of MCPIP (show ZC3H12A Proteins).
Th2 immunity mediated by STAT6 appears to play a protective role in a murine model of prurigo
Data suggest that transcription factor STAT6 regulates the recruitment of eosinophils to the lung during the development of allergic asthma.
the cross talk between HDAC4 (show HDAC5 Proteins) and STAT6 is an important regulatory mechanism of Arg1 (show ARG1 Proteins) transcription in dendritic cells
TSLP (show TSLP Proteins) induces mast cell development and aggravates allergic reactions through the activation of MDM2 (show MDM2 Proteins) and STAT6.
These data show that IL-4 (show IL4 Proteins) and IL-13 (show IL13 Proteins) decrease kinin receptors in a STAT6-dependent mechanism, which can be one important mechanism by which these cytokines exert their anti-inflammatory effects and impair bone resorption
T-cell-derived extrafollicular IL-4 (show IL4 Proteins)/IL-13 (show IL13 Proteins) and signal transducer and activator of transcription 6-regulated genes in B cells play a critical role for orchestration of the GC response in type 2 immunity.
the majority of intrathoracic SFTs exhibited STAT6 nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type.
Case Report: NAB2 (show NAB2 Proteins)-STAT6 fusion in glioblastoma.
A constitutively activated form of STAT6 is able to bypass IL-4 (show IL4 Proteins) upstream signalling and instruct dendritic-cell-specific functional DNA methylation (show HELLS Proteins) changes
interleukin-4 (show IL4 Proteins) regulates hematopoietic lineage choice by activating the JAK3 (show JAK3 Proteins)-STAT6 pathway, which causes dendritic-cell-specific DNA demethylation
Immunohistochemistry results indicate that combination with ALDH1 (show ALDH1A1 Proteins) and STAT6 can improve the diagnostic value of CD34 (show CD34 Proteins) for solitary fibrous tumors.
T allele of rs324011 in STAT6 would increase the risk of atopic dermatitis (AD) occurrence in children. Haplotypes of rs324011/rs167769 were also significantly associated with childhood AD in Taiwanese population.
These results suggest that STAT6 plays an important role in regulating Sp1 (show PSG1 Proteins) and BCL6 (show BCL6 Proteins) through STAT2 (show STAT2 Proteins) to exert the anti-proliferative effects of type I IFN.
We delineate the common and rare NAB2 (show NAB2 Proteins)-STAT6 fusion variants in solitary fibrous tumors
STAT6 is a direct target of miR (show MLXIP Proteins)-361-5p and promotes Bcl-xL (show BCL2L1 Proteins) expression.
This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 nuclear expression and NAB2 (show NAB2 Proteins)-STAT6 fusion similar to their soft tissue counterparts.
Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak (show JAK3 Proteins)/STAT6 and phosphorylation and translocation of FoxO1 (show FOXO1 Proteins) from the nucleus to the cytoplasm.
Results provide evidence that polymorphisms in STAT6 are associated with carcass and growth efficiency traits
IL-4 (show IL4 Proteins) and STAT6 are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
signal transducer and transcription activator 6
, STAT, interleukin4-induced
, signal transducer and activator of transcription 6
, transcription factor IL-4 STAT