STAT6 Protein (His tag)
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- Target See all STAT6 Proteins
- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This STAT6 protein is labelled with His tag.
- Purpose
- Recombinant Human STAT6 Protein (Baculovirus, His Tag)
- Sequence
- Met 1-Trp 847
- Characteristics
- A DNA sequence encoding the human STAT6 isoform 1 (P42226-1) (Met 1-Trp 847) was fused with a polyhistidine tag at the C-terminus.
- Purity
- > 90 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product STAT6 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 20 % glycerol, 0.3 mM DTT
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
- Alternative Name
- STAT6 (STAT6 Products)
- Synonyms
- D12S1644 Protein, IL-4-STAT Protein, STAT6B Protein, STAT6C Protein, signal transducer and activator of transcription 6 Protein, signal transducer and activator of transcription 6-like Protein, STAT6 Protein, Stat6 Protein, LOC100859543 Protein
- Background
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Background: Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-?B and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggest that the direct interaction between Stat6 and NF-?B may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-?B.
Synonym: Signal Transducer and Activator of Transcription 6; IL-4 Stat; STAT6;IL-4-STAT;STAT6B;STAT6C
- Molecular Weight
- 95.5 kDa
- Pathways
- JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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