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Cep85 is a bona fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1gamma (also known as PPP1CC (show PPP1CC Proteins)) to antagonize Nek2A
The results suggest that overexpression of NEK2 has the potential to serve as a biomarker for PCa (show ENPP1 Proteins) prognosis.
Nek2 transgenic mice develop spontaneous germinal centers and exhibit an enhanced T cell dependent immune response our data demonstrates a novel role for Nek2 in regulating B cell development and the immune response
these data indicate that Nek2 has a pivotal role in breast cancer growth at primary and secondary sites, and thus may be an attractive and novel therapeutic target for this disease.
CIP2A (show KIAA1524 Proteins) strongly interacts with NEK2 during G2/M phase, thereby enhancing NEK2 kinase activity to facilitate centrosome separation in a PP1 (show PPP1CC Proteins)- and PP2A (show PPP2R2B Proteins)-independent manner.
Nek2 and its substrate, centrobin/Nip2, are required for proper meiotic spindle formation of the mouse oocytes
Data show that NEK2 was identified as a tumor-associated antigen.
Nek2 may be a mitotic regulator that is involved in diverse cell cycle events.
Tcp10 promoter-directed expression of the Nek2 gene in mouse meiotic spermatocytes.
The MAPK (show MAPK1 Proteins) pathway triggers activation of Nek2 during chromosome condensation in mouse spermatocytes.
NEK2 modulates hepatoma cell functions, including growth, drug resistance, metastasis and angiogenesis via downstream genes activation
Alteration of NEK2 protein levels may contribute to invasion and metastasis of hepatocellular carcinoma
the functional roles of NEK2 in cancer development (review)
NEK2 was associated with unfavorable outcomes in HCC (show FAM126A Proteins) patients.
enhanced NEK2 expression in hepatocellular carcinoma (HCC (show FAM126A Proteins)) promotes HCC (show FAM126A Proteins) progression and drug resistance by promoting PP1 (show PPA1 Proteins)/Akt (show AKT1 Proteins) and Wnt (show WNT2 Proteins) pathway activation, which may represent a new therapeutic target for HCC (show FAM126A Proteins).
Our findings demonstrated that NEK2 could be a valuable carcinogenic factor and a promising therapeutic target for primary liver cancer
Suggest elevated Nek2 protein expression may be an independent risk factor for colon cancer.
Hepatocellular carcinoma patients with high NEK2 expression had significantly poor recurrence-free survival (p=0.042) and early recurrence after hepatectomy.
Kif24 is a physiological substrate of Nek2, which regulates cilia disassembly through a concerted mechanism involving Kif24-mediated microtubule depolymerization.
This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene.
NIMA (never in mitosis gene a)-related kinase 2
, NIMA - related expressed kinase 2
, NIMA-related expressed kinase 2
, NIMA-related kinase 2
, Nek2 kinase
, never in mitosis A-related kinase 2
, nimA-related protein kinase 2
, serine/threonine-protein kinase Nek2
, serine/threonine protein kinase Nek2
, nimA-like protein kinase 1