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Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Proteins (PPP1CA)
On www.antibodies-online.com are 14 Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) Proteins from 7 different suppliers available. Additionally we are shipping Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Antibodies (130) and Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Kits (9) and many more products for this protein. A total of 160 Protein Phosphatase 1, Catalytic Subunit, alpha Isoform products are currently listed.
Synonyms:
2310003C21Rik, 2900017D14Rik, AI427932, AU017636, dism2, MMPa-2, MPPa-1, PP-1A, PP1A, PP1alpha, PP2C-ALPHA, PP2CA, PP2Calpha, PPP1A, Ppp1c, wu:fc04c08, wu:fc09b07, wu:fc30g11, wu:fe05h08, zgc:85729
list all proteins Gene Name GeneID UniProt
PPP1CA 19045 P62137
PPP1CA 5499 P62136
PPP1CA 24668 P62138

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Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Proteins (PPP1CA) by Origin

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Top referenced Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Proteins

  1. Human PPP1CA Protein expressed in Escherichia coli (E. coli) - ABIN667526 : He, Gross, Roizman et al.: The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the ... in Proceedings of the National Academy of Sciences of the United States of America 1997 (PubMed)
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More Proteins for Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Interaction Partners

Mouse (Murine) Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) interaction partners

  1. Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 (show GNB1 Proteins) interact in quiescent platelets; then, Ppp1ca and Plcb3 (show PLCB3 Proteins) interact during platelet aggregation; thus, Gnb1 (show GNB1 Proteins) enlists Ppp1ca to modulate G protein-coupled receptor (show GPR34 Proteins) signaling. (Ppp1ca = protein phosphatase 1 (show PPP1CB Proteins), catalytic subunit alpha; Gnb1 (show GNB1 Proteins) = guanine nucleotide-binding protein (show TRIM23 Proteins), subunit beta-1; Plcb3 (show PLCB3 Proteins) = phospholipase C (show PLC Proteins), subunit beta-3)

  2. findings demonstrate a novel regulatory circuit in which STING and TBK1 (show TBK1 Proteins) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A (show PPM1A Proteins) dephosphorylates STING and TBK1 (show TBK1 Proteins)

  3. the studies presented here position PPM1A (show PPM1A Proteins) as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions

  4. Ang (show ANG Proteins) IV functions via regulating the activity of PP1 (show PPP1CC Proteins)

  5. a nuclear envelope-localized mechanism of inactivating TGF-beta (show TGFB1 Proteins) signaling in which MAN1 (show LEMD3 Proteins) competes with transcription factors for binding to Smad2 (show SMAD2 Proteins) and Smad3 (show SMAD3 Proteins) and facilitates their dephosphorylation by PPM1A (show PPM1A Proteins).

  6. Although a non-myristoylated mutation (G2A (show GPR132 Proteins)) of PPM1A (show PPM1A Proteins) and PPM1B (show PPM1B Proteins) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (show GRK4 Proteins).

  7. we found that PPM1A (show PPM1A Proteins) mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A (show PPM1A Proteins) protein

  8. Cell surface expression of the major amyloid-beta peptide (Abeta (show APP Proteins))-degrading enzyme, neprilysin (show MME Proteins), depends on phosphorylation by mitogen-activated protein kinase (show MAPK1 Proteins)/extracellular signal-regulated kinase kinase (MEK (show MDK Proteins)) and dephosphorylation by protein phosphatase 1a (show PPM1A Proteins).

  9. analysis of selective regulation of NR2B (show GRIN2B Proteins) by protein phosphatase-1 (show PPP1CB Proteins) for the control of the NMDA receptor in neuroprotection

  10. Protein phosphatase PPM1A (show PPM1A Proteins) regulates the nuclear export of Smad2 (show SMAD2 Proteins)/3 through targeting nuclear exporter RanBP3 (show RANBP3 Proteins).

Human Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) interaction partners

  1. establish PPM1A (show PPM1A Proteins) as a novel repressor of the SMAD3 (show SMAD3 Proteins) pathway in renal fibrosis

  2. Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a (show EIF2S1 Proteins) phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (show ATF4 Proteins) expression. (eIF2a (show EIF2S1 Proteins) = eukaryotic initiation factor-2alpha (show EIF2S1 Proteins); PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 (show ATF4 Proteins) = activating transcription factor 4 (show ATF4 Proteins))

  3. Report a tumor-suppressive function of PPM1A (show PPM1A Proteins) and an independent relationship to Smad4 (show SMAD4 Proteins) in pancreatic ductal adenocarcinoma.

  4. Protein phosphatase 1 (show PPP1CB Proteins) (PP1 (show PPA1 Proteins)) forms stable complexes with PP1 (show PPA1 Proteins)-interacting proteins (PIPs (show GPRASP1 Proteins)) that guide the phosphatase throughout its life cycle and control its fate and function.

  5. The authors found that RNA recognition motif 1 (RRM1 (show RRM1 Proteins)) in SRSF1 (show SRSF1 Proteins) binds PP1 (show PPA1 Proteins) and represses its catalytic function through an allosteric mechanism.

  6. this study shows a pivotal role for PP1 (show PPA1 Proteins) in impeding IRF7 (show IRF7 Proteins)-mediated IFN-alpha (show IFNA Proteins) production in host immune responses

  7. hydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha (show PPM1A Proteins) between the active and inactive states

  8. In a nested case control study of ischemic stroke, there was an epigenome-wide association for cg04985020 (PPM1A (show PPM1A Proteins); P=1.78x10(-07)) with vascular recurrence in patients treated with aspirin.

  9. The data support a model where Cdc7 (show CDC7 Proteins) (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 (show CDC7 Proteins) and PP1a/Cdk1 (show CDK1 Proteins) to the regulation of once-per-cell cycle DNA replication in mammalian cells.

  10. These results indicate that PP1 (show PPA1 Proteins) is recruited to the extracellular calcium-dependent E-cadherin (show CDH1 Proteins)-catenin-PIP5K1a (show PIP5K1A Proteins) complex in the plasma membrane to activate PIP5K1a (show PIP5K1A Proteins), which is required for PLC (show HSPG2 Proteins)-g1 activation leading to keratinocyte differentiation.

Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA)

  • protein phosphatase 1, catalytic subunit, alpha isozyme (ppp1ca)
  • protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA)
  • protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca)
  • protein phosphatase 1, catalytic subunit, alpha isoform a (ppp1caa)
  • protein phosphatase 1, catalytic subunit, alpha isozyme (Ppp1ca)
  • protein phosphatase 1, catalytic subunit, beta isozyme (Ppp1cb)
  • protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (PPM1A)
  • 2310003C21Rik protein
  • 2900017D14Rik protein
  • AI427932 protein
  • AU017636 protein
  • dism2 protein
  • MMPa-2 protein
  • MPPa-1 protein
  • PP-1A protein
  • PP1A protein
  • PP1alpha protein
  • PP2C-ALPHA protein
  • PP2CA protein
  • PP2Calpha protein
  • PPP1A protein
  • Ppp1c protein
  • wu:fc04c08 protein
  • wu:fc09b07 protein
  • wu:fc30g11 protein
  • wu:fe05h08 protein
  • zgc:85729 protein

Protein level used designations for PPP1CA

Protein phosphatase type 1 alpha, catalytic subunit , protein phosphatase 1, catalytic subunit, alpha isoform , PP-1A , serine/threonine-protein phosphatase PP1-alpha catalytic subunit , ppp1ca , protein phosphatase 1, catalytic subunit, alpha , serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit , protein phosphatase-1d , PP-1B , protein phosphatase 1, catalytic subunit, beta isoform , protein phosphatase-1a , serine/threonine-protein phosphatase PP1-beta catalytic subunit , Mpp alpha , PP2C-alpha , protein phosphatase 1A , protein phosphatase 2C isoform alpha , protein phosphatase IA , protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform , IA , protein phosphatase 2C alpha

GENE ID SPECIES
379914 Xenopus laevis
745709 Pan troglodytes
100059233 Equus caballus
100145598 Xenopus (Silurana) tropicalis
19045 Mus musculus
407980 Danio rerio
5499 Homo sapiens
24668 Rattus norvegicus
516175 Bos taurus
403609 Canis lupus familiaris
100009298 Oryctolagus cuniculus
25594 Rattus norvegicus
19042 Mus musculus
5494 Homo sapiens
281994 Bos taurus
100009431 Oryctolagus cuniculus
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