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Results show that SKA1 expression is regulated by mir (show MLXIP Proteins)-10a. Its knockdown inhibits migration and invasion in renal cell carcinoma (show MOK Proteins) cells.
Study indicated that hypoxia mediated downregulation of SKA1 expression increased the chemotherapy resistance in human osteosarcoma cells.
Kinetochores mature through Ska1/ska2 (show FAM33A Proteins)/Ska3 (show SKA3 Proteins) complex recruitment and this is required for improved load-bearing capacity and silencing of the spindle assembly checkpoint.
In conclusion, our findings suggest that spindle and kinetochore-associated protein 1 could serve as a potential therapeutic target in prostate cancer patients.
Thus, the Ska complex, specifically the Ska1 C-terminal domain, recruits PP1 (show PPA1 Proteins) to kinetochores to oppose spindle checkpoint signaling kinases and promote anaphase onset.
SKA1 is required for metastasis and cisplatin resistance of non-small cell lung cancer.
Thus, our findings identified a definite regulatory mechanism of the search and capture process for stable spindle attachment through cross-talk between spindle dynamics and KT composition mediated by DDA3 (show PSRC1 Proteins) and Ska1.
knockdown of SKA1 could potently suppress bladder cancer cell proliferation in vitro and lentivirus-mediated silencing of SKA1 might serve as a novel strategy for gene therapy of bladder cancer.
Results show that high SKA1 expression is predictive of poor prognosis of papillary thyroid carcinoma (PTC (show F9 Proteins)), implying it as a promising new target for PTC (show F9 Proteins) therapies.
SKA1 could be used for gastric cancer early diagnosis as a biomarker.
Ska1 over-expression promotes tumourigenesis
The Ska1 subunit was only localized on spindle microtubules from the Pro-MI to MII stages in mouse oocyte meiosis and knockdown by Morpholino injection into mouse oocytes resulted in spindle movement defects and enlarged polar bodies.
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules (By similarity).
spindle and kinetochore-associated protein 1
, spindle and KT (kinetochore) associated 1
, spindle and KT associated 1