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Browse our SKA1 Proteins (SKA1)

Full name:
Spindle and Kinetochore Associated Complex Subunit 1 Proteins (SKA1)
On are 8 Spindle and Kinetochore Associated Complex Subunit 1 (SKA1) Proteins from 3 different suppliers available. Additionally we are shipping SKA1 Antibodies (31) and many more products for this protein. A total of 44 SKA1 products are currently listed.
2810433K01Rik, AV117428, C18H18orf24, C18orf24, RGD1310784
list all proteins Gene Name GeneID UniProt
SKA1 220134 Q96BD8
SKA1 66468 Q9CPV1
SKA1 291441 B0BN28

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SKA1 Proteins (SKA1) by Origin

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More Proteins for SKA1 Interaction Partners

Human Spindle and Kinetochore Associated Complex Subunit 1 (SKA1) interaction partners

  1. Thus, the Ska complex, specifically the Ska1 C-terminal domain, recruits PP1 (show PPA1 Proteins) to kinetochores to oppose spindle checkpoint signaling kinases and promote anaphase onset.

  2. SKA1 is required for metastasis and cisplatin resistance of non-small cell lung cancer.

  3. Thus, our findings identified a definite regulatory mechanism of the search and capture process for stable spindle attachment through cross-talk between spindle dynamics and KT composition mediated by DDA3 (show PSRC1 Proteins) and Ska1.

  4. knockdown of SKA1 could potently suppress bladder cancer cell proliferation in vitro and lentivirus-mediated silencing of SKA1 might serve as a novel strategy for gene therapy of bladder cancer.

  5. Results show that high SKA1 expression is predictive of poor prognosis of papillary thyroid carcinoma (PTC (show F9 Proteins)), implying it as a promising new target for PTC (show F9 Proteins) therapies.

  6. SKA1 could be used for gastric cancer early diagnosis as a biomarker.

  7. the kinetochore-associated Ska complex interacts with tubulin (show TUBB Proteins) monomers via the carboxy-terminal winged-helix domain of Ska1, providing the structural basis for the ability to bind both straight and curved microtubule structures.

  8. Ska1 over-expression promotes tumourigenesis

  9. Data suggest that SKA1 plays an important role in the proliferation of hepatocellular carcinoma cells

  10. the conserved kinetochore-localized Ska1 complex tracks with depolymerizing microtubule ends and associates with both the microtubule lattice and curved protofilaments

Mouse (Murine) Spindle and Kinetochore Associated Complex Subunit 1 (SKA1) interaction partners

  1. Ska1 over-expression promotes tumourigenesis

  2. The Ska1 subunit was only localized on spindle microtubules from the Pro-MI to MII stages in mouse oocyte meiosis and knockdown by Morpholino injection into mouse oocytes resulted in spindle movement defects and enlarged polar bodies.

SKA1 Protein Profile

Protein Summary

Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules (By similarity).

Alternative names and synonyms associated with SKA1

  • spindle and kinetochore associated complex subunit 1 (SKA1)
  • spindle and kinetochore associated complex subunit 1 (ska1)
  • spindle and kinetochore associated complex subunit 1 (Ska1)
  • 2810433K01Rik protein
  • AV117428 protein
  • C18H18orf24 protein
  • C18orf24 protein
  • RGD1310784 protein

Protein level used designations for SKA1

spindle and kinetochore-associated protein 1 , spindle and KT (kinetochore) associated 1 , spindle and KT associated 1

700712 Macaca mulatta
100144953 Xenopus (Silurana) tropicalis
220134 Homo sapiens
66468 Mus musculus
291441 Rattus norvegicus
491691 Canis lupus familiaris
507703 Bos taurus
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