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Full name:
Sperm Associated Antigen 5 ELISA Kits (SPAG5)
On www.antibodies-online.com are 4 Sperm Associated Antigen 5 (SPAG5) ELISA Kits from 3 different suppliers available. Additionally we are shipping SPAG5 Antibodies (35) and SPAG5 Proteins (4) and many more products for this protein. A total of 47 SPAG5 products are currently listed.
Synonyms:
AI874642, D11Bhm180e, Deepest, hMAP126, MAP126, Mastrin, S17, SPAG5
list all ELISA KIts Gene Name GeneID UniProt
SPAG5 10615 Q96R06
Mouse SPAG5 SPAG5 54141 Q7TME2
Rat SPAG5 SPAG5 252918  

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Human Sperm Associated Antigen 5 (SPAG5) interaction partners

  1. Low SPAG5 expression is associated with low chemotherapy sensitivity in breast cancer.

  2. findings reveal a direct physical link between two important regulators of mitotic progression and demonstrate the critical role of the NuMA (show NUMA1 ELISA Kits)-Astrin interaction for accurate cell division.

  3. Mechanistically, Plk1 (show PLK1 ELISA Kits) acts as an upstream kinase for Astrin phosphorylation by Cdk1 (show CDK1 ELISA Kits) and targeting phospho-Astrin to KTs, leading to the recruitment of outer KT components, such as Cenp-E (show CENPE ELISA Kits), and the stable attachment of spindles to KTs.

  4. Results showed a progression-driving role of SPAG5 in prostate cancer which can be regulated by miR (show MLXIP ELISA Kits)-539.

  5. Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP (show KNSTRN ELISA Kits) and Astrin have been reported.

  6. SPAG5 upregulation relates to poor prognosis in cervical cancer patients, and SPAG5 is a regulator of mTOR (show FRAP1 ELISA Kits) activity during taxol treatment in cervical cancer.

  7. Astrin acts as a mitotic phosphoprotein during the regulation of mitosis.

  8. Study identifies astrin as an essential negative mTORC1 regulator in the cellular stress response. Upon stress, astrin inhibits mTORC1 association and recruits the mTORC1 component raptor (show RPTOR ELISA Kits) to stress granules, thereby preventing mTORC1-hyperactivation-induced apoptosis.

  9. Data show that CLASP1 (show CLASP1 ELISA Kits)-astrin-Kif2b (show KIF2B ELISA Kits) complex acts as a central switch at kinetochores that defines mitotic progression and promotes fidelity by temporally regulating kinetochore-microtuble attachments.

  10. These findings suggest that the silencing of astrin induce a p53 (show TP53 ELISA Kits)-dependent apoptosis and has an additive effect on paclitaxel treatment.

Mouse (Murine) Sperm Associated Antigen 5 (SPAG5) interaction partners

  1. cloning and genomic structure of mastrin; mastrin protein was demonstrated to localize to mitotic spindles during mitosis[masatrin]

  2. Loss-of-function of Astrin by RNAi and overexpression of the coiled-coil domain results in spindle disorganization, chromosome misalignment and meiosis progression arrest.

SPAG5 Antigen Profile

Antigen Summary

This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.

Alternative names and synonyms associated with SPAG5

  • sperm associated antigen 5 (SPAG5) Elisa Kit
  • sperm associated antigen 5 (Spag5) Elisa Kit
  • AI874642 Elisa Kit
  • D11Bhm180e Elisa Kit
  • Deepest Elisa Kit
  • hMAP126 Elisa Kit
  • MAP126 Elisa Kit
  • Mastrin Elisa Kit
  • S17 Elisa Kit
  • SPAG5 Elisa Kit

Protein level used designations for SPAG5

sperm associated antigen 5 , sperm-associated antigen 5-like , astrin , mitotic spindle associated protein p126 , mitotic spindle coiled-coil related protein , mitotic spindle-associated protein p126 , sperm-associated antigen 5 , microtubule-associated protein

GENE ID SPECIES
709400 Macaca mulatta
739263 Pan troglodytes
100059272 Equus caballus
100286810 Sus scrofa
100466628 Ailuropoda melanoleuca
100602580 Nomascus leucogenys
10615 Homo sapiens
54141 Mus musculus
252918 Rattus norvegicus
480623 Canis lupus familiaris
504585 Bos taurus
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