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USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry
USP44 is epigenetically inactivated in colorectal adenomas, but this alone is not sufficient to cause aneuploidy in colorectal neoplasia.
findings implicate USP44 in negative regulation of the RNF8 (show RNF8 Proteins)/RNF168 (show RNF168 Proteins) pathway
Data identify Cdc20 (show CDC20 Proteins), USP44, and Wee1 (show WEE1 Proteins) as relevant Fcp1 (show CTDP1 Proteins) targets.
These data are consistent with an important role for USP44 in regulating Cdc20 (show CDC20 Proteins)-APC (show APC Proteins)/C activity and suggest that high levels of this enzyme may contribute to the pathogenesis of T-cell leukemias.
a dynamic balance of ubiquitination by the APC (show APC Proteins) and deubiquitination by USP44 contributes to the generation of the switch-like transition controlling anaphase entry
USP44 inhibited chromosome segregation errors independent of its role in the mitotic checkpoint (show BUB3 Proteins) by regulating centrosome separation, positioning, and mitotic spindle geometry.
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004
ubiquitin specific peptidase 44
, ubiquitin thiolesterase 44
, ubiquitin carboxyl-terminal hydrolase 44-like
, Deubiquitinating enzyme 44-A
, Ubiquitin thiolesterase 44-A
, Ubiquitin-specific-processing protease 44-A
, ubiquitin carboxyl-terminal hydrolase 44-A
, ubiquitin thioesterase 44-A
, Deubiquitinating enzyme 44-B
, Ubiquitin thiolesterase 44-B
, Ubiquitin-specific-processing protease 44-B
, ubiquitin carboxyl-terminal hydrolase 44-B
, ubiquitin thioesterase 44-B
, ubiquitin carboxyl-terminal hydrolase 44
, ubiquitin specific peptidase 49
, Deubiquitinating enzyme 44
, Ubiquitin thiolesterase 44
, Ubiquitin-specific-processing protease 44
, ubiquitin thioesterase 44
, deubiquitinating enzyme 44
, ubiquitin specific protease 44
, ubiquitin-specific-processing protease 44
, inactive deubiquitinating enzyme 44
, inactive ubiquitin carboxyl-terminal hydrolase 44
, inactive ubiquitin thioesterase 44
, inactive ubiquitin-specific-processing protease 44
, ubiquitin specific peptidase 49 pseudogene
, Ubiquitin carboxyl-terminal hydrolase 44