Browse our NDC80 Proteins (NDC80)

Full name:
NDC80 Kinetochore Complex Component Homolog (S. Cerevisiae) Proteins (NDC80)
On www.antibodies-online.com are 5 NDC80 Kinetochore Complex Component Homolog (S. Cerevisiae) (NDC80) Proteins from 3 different suppliers available. Additionally we are shipping NDC80 Antibodies (97) and NDC80 Kits (1) and many more products for this protein. A total of 110 NDC80 products are currently listed.
Synonyms:
2610020P18Rik, AV139730, CG9938, Dmel\\CG9938, dmNdc80, dNdc80, HEC, HEC1, HsHec1, hsNDC80, kntc2, kntc2l, ndc10, NDC80, TID3, wu:fb52e02, zgc:111801
list all proteins Gene Name GeneID UniProt
NDC80 67052 Q9D0F1
NDC80 10403 O14777

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NDC80 Proteins (NDC80) by Origin

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More Proteins for NDC80 Interaction Partners

Fruit Fly (Drosophila melanogaster) NDC80 Kinetochore Complex Component Homolog (S. Cerevisiae) (NDC80) interaction partners

  1. kinetochores movement depends on SPC105R, can occur in the absence of NDC80, and is antagonized by plus-end directed forces from the CENP-E (show CENPE Proteins) motor.

Mouse (Murine) NDC80 Kinetochore Complex Component Homolog (S. Cerevisiae) (NDC80) interaction partners

  1. Further investigation of the phosphoregulation of meiotic Kif4 revealed that Aurora Kinase and Cdk activity is critical for Kif4 kinetochore localization and interaction with Ndc80 and CENP-C. Finally, Kif4 protein but not gene expression was found to be upregulated with age, suggesting a role for this protein in the decline of oocyte quality with age

  2. Hec1-dependent cyclin B2 (show CCNB2 Proteins) stabilization during early metaphase is important for early-stage spindle assembly.

  3. Disruption of Ndc80 function by either siRNA injection or antibody injection resulted in severe chromosome misalignment, spindle disruption, and precocious polar body extrusion.

  4. overexpression of Hec1 results in mitotic checkpoint (show BUB3 Proteins) hyperactivation that leads to aneuploidy sufficient to generate tumors

Human NDC80 Kinetochore Complex Component Homolog (S. Cerevisiae) (NDC80) interaction partners

  1. Expression of NDC80 in colon cancer cells and tissues was higher than that in controls. NDC80 promotes the proliferation and metastasis of colon cancer cells.

  2. Ndc80 complex bound to microtubules binds every tubulin (show TUBB Proteins) monomer along the microtubule protofilament.

  3. we conclude that Hec1 is consistently overexpressed in human PCa (show FLVCR1 Proteins) and Hec1 is closely linked with human PCa (show FLVCR1 Proteins) progression through the meditator LncRNA BX647187

  4. Independent molecular binding events to microtubules (MTs (show TIMM8A Proteins)) by individual NDC80 complexes, rather than their structured oligomers, regulate the dynamics and stability of kinetochore-MT attachments in dividing cells.

  5. The Ndc80 complex binds straight microtubules by recognizing the dimeric interface of tubulin (show TUBB Proteins).

  6. Overproduction of Ndc80 in cancer cells may unfavourably absorb protein interactors through the internal loop domain and lead to a change in the equilibrium of microtubule-associated proteins. [Review]

  7. N-terminus-modified Hec1 suppresses tumour growth by interfering with kinetochore-microtubule dynamics

  8. Mechanisms of mitosis-specific assembly of the checkpoint platform Knl1/MIS12 (show MIS12 Proteins)/NDC80 at human kinetochores.

  9. Certain clinical subtypes of breast cancer more likely to respond to Hec1-targeted therapy were identified and these subtypes are the ones associated with poor prognosis.

  10. Hec1 is critical in maintaining the in vitro and in vivo growth of gastric cancer cells; elevated Hec1 levels may occur at the early stage of gastric tumorigenesis

Xenopus laevis NDC80 Kinetochore Complex Component Homolog (S. Cerevisiae) (NDC80) interaction partners

  1. mature attachment via the Ndc80 complex is essential for metaphase alignment and anaphase A

NDC80 Protein Profile

Protein Summary

This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation.

Alternative names and synonyms associated with NDC80

  • NDC80 kinetochore complex component (NDC80)
  • CG9938 gene product from transcript CG9938-RA (Ndc80)
  • NDC80 homolog, kinetochore complex component (S. cerevisiae) (NDC80)
  • NDC80 kinetochore complex component homolog (S. cerevisiae) (NDC80)
  • spindle pole body protein Ndc80 (ndc80)
  • kinetochore protein Ndc80 (ndc80)
  • Kinetochore protein NDC80 homolog (ndc80)
  • NDC80 homolog, kinetochore complex component (S. cerevisiae) (Ndc80)
  • NDC80 homolog, kinetochore complex component (S. cerevisiae) (ndc80)
  • NDC80 kinetochore complex component (ndc80)
  • 2610020P18Rik protein
  • AV139730 protein
  • CG9938 protein
  • Dmel\\CG9938 protein
  • dmNdc80 protein
  • dNdc80 protein
  • HEC protein
  • HEC1 protein
  • HsHec1 protein
  • hsNDC80 protein
  • kntc2 protein
  • kntc2l protein
  • ndc10 protein
  • NDC80 protein
  • TID3 protein
  • wu:fb52e02 protein
  • zgc:111801 protein

Protein level used designations for NDC80

kinetochore associated 2 , CG9938-PA , Hec1 , Ndc80-PA , NDC80 homolog, kinetochore complex component (S. cerevisiae) , NDC80 homolog, kinetochore complex component , kinetochore protein NDC80 homolog , kinetochore protein Ndc80 , Kinetochore protein NDC80 homolog , highly expressed in cancer, rich in leucine heptad repeats , kinetochore protein Hec1 , kinetochore-associated protein 2 , HEC (highly expressed in cancer) , NDC80 kinetochore complex component homolog , highly expressed in cancer protein , retinoblastoma-associated protein HEC , kinetochore spindle checkpoint protein Ndc80 , xNdc80

GENE ID SPECIES
100226934 Taeniopygia guttata
32316 Drosophila melanogaster
455320 Pan troglodytes
480190 Canis lupus familiaris
538789 Bos taurus
2540097 Schizosaccharomyces pombe 972h-
8624354 Dictyostelium discoideum AX4
100051228 Equus caballus
100073682 Ornithorhynchus anatinus
100380518 Salmo salar
100454766 Pongo abelii
100465936 Ailuropoda melanoleuca
100583588 Nomascus leucogenys
67052 Mus musculus
445386 Danio rerio
10403 Homo sapiens
398429 Xenopus laevis
395134 Gallus gallus
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