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Our findings reveal a distinct role of STAF65gamma in nuclear import, transcriptional repression, and cell cycle regulation at high levels of expression, which is associated with poor clinical outcomes of lung adenocarcinoma.
A novel peptide ligand recognized by tumor-specific CD4 (show CD4 Proteins)+ T regulatory (Treg) cells is a dominant peptide derived from the mutated ARTC1 (show ART1 Proteins) gene. ARTC1 (show ART1 Proteins) peptide-activated CD4 (show CD4 Proteins)+ Treg cells suppress proliferation and IL-2 (show IL2 Proteins) secretion of melanoma-reactive T cells.
optimal binding of STAGA to p53 involves interactions of STAGA subunits TAF9, GCN5, and ADA2b, respectively
SUPT7L is a protein subunit of the human STAGA complex (SPT3\; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001
SPTF-associated factor 65 gamma
, STAGA complex 65 gamma subunit
, STAGA complex 65 subunit gamma
, adenocarcinoma antigen ART1
, suppressor of Ty 7-like