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SYNE2 is important for normal retinal development. We have determined that not only is photoreceptor nuclear migration affected, but also the positions of Muller glia and secondary neurons are disturbed early in retinal development
nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.
Loss of Nesprin 1 or 2, or both, led to impairment of gene expression changes in response to biomechanical stimuli. These data suggest a model whereby biomechanical signals are communicated from proteins of the outer nuclear membrane
ectopic expression of BRAP2 (show BRAP Proteins) inhibits nuclear localization of HMG20A (show HMG20A Proteins) and NuMA1, and prevents nuclear envelope accumulation of SYNE2
Data indicate roles for linkers of nucleus to cytoskeleton (LINC) molecules nesprin2giant and nesprin3, which anchor actin cap fibers to the nucleus.
functions for Nesprin-2 at the nuclear envelope (NE) in gene regulation and in regulation of the actin cytoskeleton which impact on wound healing
Syne-2, SUN1 (show SUN1 Proteins) and SUN2 (show SUN2 Proteins) play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development.
The p104 (show RB1 Proteins) protein interacts with p85alpha and is involved in the regulation of p27(Kip1 (show CDKN1B Proteins)) expression for the reduction of cellular proliferation.
The Nesprin-2 the conserved C-terminal amino acids PPPX is essential for the interaction with a C-terminal region in Sun1 (show SUN1 Proteins).
SUN1 (show SUN1 Proteins) interacts with nuclear lamin A (show LMNA Proteins) and cytoplasmic nesprins (nesprin-1 and nesprin-2)to provide a physical connection between the nuclear lamina and the cytoskeleton.
The authors identified the nuclear envelope protein (show SUN2 Proteins) nesprin-2 as a binding partner for fascin (show FSCN1 Proteins) in a range of cell types in vitro and in vivo. Nesprin-2 interacts with fascin (show FSCN1 Proteins) through a direct, F-actin-independent interaction, and this binding is distinct and separable from a role for fascin (show FSCN1 Proteins) within filopodia at the cell periphery.
these data identify N-terminal nesprin-2 variants as novel regulators of beta-catenin (show CTNNB1 Proteins) signaling.
We show that AMPH-1 (show AMPH Proteins)/BIN1 (show BIN1 Proteins) binds to nesprin and actin, as well as to the microtubule-binding protein CLIP170 in both species. We propose that BIN1 (show BIN1 Proteins) has a direct and evolutionarily conserved role in nuclear positioning, altered in myopathies.
nesprin-1 and nesprin-2 both regulate nuclear and cytoplasmic architecture.
Each mutation in LMNA (show LMNA Proteins) has a distinct impact on the Nersprin-2 interaction that substantially explains how distinct mutations in widely expressed genes lead to the formation of phenotypically different diseases.
High Nesprin-2 expression is associated with colorectal cancer.
ectopic expression of BRAP2 (show BRAP Proteins) inhibits nuclear localization of HMG20A (show HMG20A Proteins) and NuMA1, and prevents nuclear envelope accumulation of SYNE2.
Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.
Study presents crystal structures of the human SUN2-KASH1/2 complex, i.e. SUN2 complexed with the C-terminal 29 residues of human Nesprin-1 or -2 (the core of the LINC complex).
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene.
spectrin repeat containing, nuclear envelope 2
, synaptic nuclear envelope 2
, nesprin 2
, nuclear envelope spectrin repeat protein 2
, nucleus and actin connecting element protein
, synaptic nuclear envelope protein 2
, nuclear envelope spectrin repeat-2
, synaptic nuclei expressed gene 2