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Rat (Rattus) MAP2K1 ELISA Kit for Sandwich ELISA - ABIN433773
Du, Wang, Wang: Role of RhoA/MERK1/ERK1/2/iNOS signaling in ocular ischemic syndrome. in Graefe's archive for clinical and experimental ophthalmology 2016
Human MAP2K1 ELISA Kit for Sandwich ELISA - ABIN419235
El-Ansary, Hassan, Qasem, Das: Identification of Biomarkers of Impaired Sensory Profiles among Autistic Patients. in PLoS ONE 2016
High MEK1 expression is associated with infant acute lymphoblastic leukemia.
Data show that combined therapy using HER2 (show ERBB2 ELISA Kits) inhibitor and BRAF (show BRAF ELISA Kits)/MEK inhibitor presented more significant redifferentiation effect on papillary thyroid cancer cells harboring BRAFV600E than BRAF (show BRAF ELISA Kits)/MEK inhibitor alone.
MEK1 is constitutively and mainly phosphorylated at the Thr (show TRH ELISA Kits)-292, Ser (show SIGLEC1 ELISA Kits)-298, Thr (show TRH ELISA Kits)-386, and Thr (show TRH ELISA Kits)-388 residues in vivo, and combinations of phosphorylations at these four residues produce at least six phosphorylated variants of MEK1. The phosphorylation statuses of Thr (show TRH ELISA Kits)-292, Ser (show SIGLEC1 ELISA Kits)-298, Thr (show TRH ELISA Kits)-386, and Thr (show TRH ELISA Kits)-388 residues vary widely during activation and deactivation of the MAPK (show MAPK1 ELISA Kits) pathway.
TNFRSF14 (show TNFRSF14 ELISA Kits) and MAP2K1 mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.
There was no statistically significant association between BRAF (show BRAF ELISA Kits) or MAP2K1 mutation and anatomic site, unifocal versus multifocal presentation, or clinical outcome in Langerhans cell histiocytosis.
High MEK1 expression is associated with inflammation.
Lgr4 (show LGR4 ELISA Kits) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 (show MAPK1/3 ELISA Kits) and Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathways.
somatic mutations in MAP2K1 are a common cause of extracranial arteriovenous malformation
MEK1 mutation is associated with central nervous system metastases of non-small cell lung cancer.
The MAP2K1 mutation analysis of three hairy cell leukemia cases, one hairy cell leukemia-variant case, and three splenic marginal zone lymphoma cases revealed negative results.
fluid shear stress induces autocrine TGF-beta (show TGFB1 ELISA Kits)/ALK5 (show TGFBR1 ELISA Kits)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1/2-mediated signaling.
FGF2 (show FGF2 ELISA Kits) is an extracellular inducer of COUP-TFII (show NR2F2 ELISA Kits) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (show NR2F2 ELISA Kits) expression prior to the onset of osteogenic differentiation
REDD1 (show DDIT4 ELISA Kits) is required for normal insulin (show INS ELISA Kits)-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1 (show DDIT4 ELISA Kits), and mTOR (show FRAP1 ELISA Kits)
blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db (show LEPR ELISA Kits) mice
MEK1 and MEK2 (show MAP2K2 ELISA Kits) can substitute for each other but a minimum amount of MEK (show MDK ELISA Kits) is critical for placenta development and embryo survival
Aberrant phosphorylation of AKT (show AKT1 ELISA Kits) and MEK (show MDK ELISA Kits) signalling pathways was identified in cells carrying mutant huntingtin (show HTT ELISA Kits).
An essential function for MEK1 in macrophages in regulating the ERK1/2 (show MAPK1/3 ELISA Kits) and STAT4 (show STAT4 ELISA Kits) pathways in response to TLR4 (show TLR4 ELISA Kits) activation.
Nuclear enrichment of MEK1 physically sequesters peroxisome proliferator-activated receptor gamma (PPARgamma (show PPARG ELISA Kits)), inhibiting adipogenesis and disrupting ERK (show EPHB2 ELISA Kits) signaling.
MEK1 is inhibited by phosphorylation at Thr (show TRH ELISA Kits)-292/286 by Cdk5 (show CDK5 ELISA Kits), ERK (show EPHB2 ELISA Kits), and Cdk1 (show CDK1 ELISA Kits).
in FGFR1 (show FGFR1 ELISA Kits) signalling JNK1 (show MAPK8 ELISA Kits) phosphorylation depends on ERK2 (show MAPK1 ELISA Kits)
The data demonstrate that ERK (show MAPK1 ELISA Kits) phosphorylation of UBF prevents DNA bending by its first two HMG (show SSRP1 ELISA Kits) boxes, leading to a cooperative unfolding of the enhancesome
We propose that Erk2 MAP kinase (show MAPK1 ELISA Kits) phosphorylation of Vg1RBP (show IGF2BP3 ELISA Kits) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.
Extracellular signal-regulated kinase (ERK (show MAPK1 ELISA Kits)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.
KSR (show KSR1 ELISA Kits) interacts with a regulatory Raf (show RAF1 ELISA Kits) molecule in cis (show CISH ELISA Kits) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (show RAF1 ELISA Kits) molecule in trans
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Data indicate that MEKK2 (show MAP3K2 ELISA Kits) is required for the mekk1 (show MAP3K1 ELISA Kits), mkk1 mkk2 (show MAP2K2 ELISA Kits), and mpk4 (show MAPK4 ELISA Kits) autoimmune phenotypes.
Data suggest that the MEKK1 (show MAP3K1 ELISA Kits)-MKK1/MKK2 (show MAP2K2 ELISA Kits)-MPK4 (show MAPK4 ELISA Kits) kinase cascade negatively regulates MEKK2 (show MAP3K2 ELISA Kits) and activation of MEKK2 (show MAP3K2 ELISA Kits) triggers SUMM2-mediated immune responses.
miR (show MYLIP ELISA Kits)-1826 plays an important role as tumor suppressor via CTNNB1 (show CTNNB1 ELISA Kits)/MEK1/VEGFC (show VEGFC ELISA Kits) downregulation in bladder cancer.
ETS1 (show ETS1 ELISA Kits) is probably mediating high CIP2A (show KIAA1524 ELISA Kits) expression in human cancers with increased EGFR (show EGFR ELISA Kits)-MEK1/2-ERK (show MAPK1 ELISA Kits) pathway activity
An analysis of the interation of MEKK1 (show MAP3K1 ELISA Kits) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.
This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.
These results suggest that the formation of SUMO-1 (show SUMO1 ELISA Kits) foci is regulated by the MEK-ERK (show MAPK1 ELISA Kits) pathway and may induce apoptosis.
AtMEK1 is a crucial mediator in plant stress signal transduction.
double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (show MAP2K2 ELISA Kits) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (show MAP3K1 ELISA Kits) and mpk4 (show MAPK4 ELISA Kits) mutants
Activation of MPK4 (show MAPK4 ELISA Kits) by flg22 is impaired in the mkk1 mkk2 (show MAP2K2 ELISA Kits) double mutants, suggesting that MKK1 and MKK2 (show MAP2K2 ELISA Kits) function together with MPK4 (show MAPK4 ELISA Kits) and MEKK1 (show MAP3K1 ELISA Kits) in a MAP kinase (show MAPK1 ELISA Kits) cascade to negatively regulate innate immune responses in plants.
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
ERK activator kinase 1
, MAP kinase kinase 1
, MAP kinase/Erk kinase 1
, MAPK/ERK kinase 1
, MAPKK 1
, dual specificity mitogen-activated protein kinase kinase 1
, mitogen-activated protein kinase kinase 1
, MEK 1
, protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
, dual specificity mitogen activated protein kinase kinase 1
, mitogen activated protein kinase kinase 1
, protein kinase, mitogen activated, kinase 1, p45
, MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2)