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|Antigen||Mitogen-Activated Protein Kinase 14 (MAPK14) Antibodies|
|Epitope||pThr180, pTyr182 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MAPK14 antibody is un-conjugated Alternatives|
Dot Blot (DB), Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-MAPK14 AntibodyTarget Details MAPK14 Application Details Handling References for anti-MAPK14 antibody (ABIN265093) Images
|Specificity||This antibody reacts to p38 MAPK (pThr180 / pTyr182).|
|Immunogen||Synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho Thr180/Tyr182 of p38|
Target Details MAPK14Product Details anti-MAPK14 Antibody Application Details Handling References for anti-MAPK14 antibody (ABIN265093) Images back to top
|Alternative Name||MAP Kinase p38 alpha / MAPK14 (MAPK14 Antibody Abstract)|
|Background||The three Mitogen-Activated Protein Kinases (MAPKs) are evolutionarily conserved protein kinases that control a vast array of cellular processes. p38 MAPK is one these kinases and it is activated by both inflammatory cytokines and by stress. The p38 MAPK is thought to be particularly important in diseases like asthma and autoimmunity but it also plays important roles in the stress response of the nervous system. Like the other MAPKs, p38 is activated by a dual specificity kinase that phosphorylates Thr180 and Tyr182.|
|Pathways||MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Hepatitis C, Toll-Like Receptors Cascades, Autophagy, Thromboxane A2 Receptor Signaling|
Application DetailsProduct Details anti-MAPK14 Antibody Target Details MAPK14 Handling References for anti-MAPK14 antibody (ABIN265093) Images back to top
Dot Blot: 1/1000. Western Blot: 1/1000. Positive Control/Tissue Expression: C-6 glioma cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAPK14 Antibody Target Details MAPK14 Application Details References for anti-MAPK14 antibody (ABIN265093) Images back to top
|Buffer||HEPES ( pH 7.5) solution containing 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage Comment||Ship on dry ice. Store (in aliquots) at -20 °C to -70 °C.|
References for anti-MAPK14 antibody (ABIN265093)Product Details anti-MAPK14 Antibody Target Details MAPK14 Application Details Handling Images back to top
Choe, McGinty: "N-Methyl-D-aspartate receptors and p38 mitogen-activated protein kinase are required for cAMP-dependent cyclase response element binding protein and Elk-1 phosphorylation in the striatum." in: Neuroscience, Vol. 101, Issue 3, pp. 607-17, 2001
ImagesProduct Details anti-MAPK14 Antibody Target Details MAPK14 Application Details Handling References for anti-MAPK14 antibody (ABIN265093) back to top