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|Application / Reactivity||Human|
|Cellular Assay (CA)||12 Antibodies|
|Dot Blot (DB)||54 Antibodies|
|Enzyme Immunoassay (EIA)||14 Antibodies|
|Flow Cytometry (FACS)||17 Antibodies|
|Immunoassay (IA)||12 Antibodies|
|Immunochromatography (IC)||4 Antibodies|
|Immunocytochemistry (ICC)||51 Antibodies|
|Immunofluorescence (IF)||129 Antibodies|
|Immunofluorescence (fixed cells) (IF/ICC)||7 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||13 Antibodies|
|Immunohistochemistry (IHC)||282 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||7 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||84 Antibodies|
|Immunoprecipitation (IP)||39 Antibodies|
|Immunostaining (ISt)||12 Antibodies|
|Western Blotting (WB)||867 Antibodies|
|Antigen||Microtubule-Associated Protein tau (MAPT) Antibodies|
|Conjugate||This MAPT antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Product Details anti-MAPT AntibodyTarget Details MAPT Application Details Handling Images
This antibody recognizes MAPT/TAU (N-term).
Cellular Localization: Cytoplasm.
|Characteristics||Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein,Paired helical filament-tau|
|Purification||Protein A/G Chromatography|
|Immunogen||Synthetic peptide derived from N-terminus of Human Tau protein|
Target Details MAPTProduct Details anti-MAPT Antibody Application Details Handling Images back to top
|Alternative Name||MAPT / tau (MAPT Antibody Abstract)|
|Background||Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules, but it also serves to link certain signaling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated Tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau. Alternate splicing of tau mRNA and differential phosphorylation contributes to the heterogeneity of Tau.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau|
|Pathways||MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size|
Application DetailsProduct Details anti-MAPT Antibody Target Details MAPT Handling Images back to top
Immunohistochemistry with Formalin-Fixed, Paraffin-Embedded tissues: 1/100Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Incubation Time: 30 minutes at RT. Positive Control: Breast carcinoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAPT Antibody Target Details MAPT Application Details Images back to top
|Buffer||PBS, pH 7.6, 0.09 % Sodium Azide, 1 % BSA|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Shelf life: one year from despatch.
|Expiry Date||12 months|
ImagesProduct Details anti-MAPT Antibody Target Details MAPT Application Details Handling back to top