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|Antigen||Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) Antibodies|
|Epitope||BH3 Domain Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This MCL-1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|1 reference available|
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Product Details anti-MCL-1 AntibodyTarget Details MCL-1 Application Details Handling ProductDetails: References for anti-MCL-1 antibody (ABIN356822) Images
|Specificity||This antibody is specific to MCL1 (BH3 Domain).|
|Purification||Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||This antibody was developed against a synthetic peptide selected from the central region (BH3 domain) of human Mcl-1.|
Target Details MCL-1Product Details anti-MCL-1 Antibody Application Details Handling ProductDetails: References for anti-MCL-1 antibody (ABIN356822) Images back to top
|Alternative Name||MCL1 (MCL1 Antibody Abstract)|
|Background||The Mcl-1 protein belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.Synonyms: BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, mcl1/EAT, r004|
|Gene ID||4170, 9606|
|Research Area||Cancer, Apoptosis/Necrosis|
Application DetailsProduct Details anti-MCL-1 Antibody Target Details MCL-1 Handling ProductDetails: References for anti-MCL-1 antibody (ABIN356822) Images back to top
ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MCL-1 Antibody Target Details MCL-1 Application Details ProductDetails: References for anti-MCL-1 antibody (ABIN356822) Images back to top
|Buffer||PBS containing 0.09 % (W/V) Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
ProductDetails: References for anti-MCL-1 antibody (ABIN356822)Product Details anti-MCL-1 Antibody Target Details MCL-1 Application Details Handling Images back to top
Johnson, Lucas, Muthusamy, Smith, Edwards, De Lay, Croce, Grever, Byrd: "Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia." in: Blood, Vol. 108, Issue 4, pp. 1334-8, 2006
ImagesProduct Details anti-MCL-1 Antibody Target Details MCL-1 Application Details Handling ProductDetails: References for anti-MCL-1 antibody (ABIN356822) back to top