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|Antigen||Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6) Antibodies|
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-RPS6KA6 AntibodyTarget Details RPS6KA6 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of Rsk-4 protein. (region surrounding Gln688)|
|Cross-Reactivity (Details)||Species reactivity (tested):Human.|
|Purity||> 95 % by SDS-PAGE|
Target Details RPS6KA6Product Details anti-RPS6KA6 Antibody Application Details Handling Images back to top
|Alternative Name||RPS6KA6 / RSK4 (RPS6KA6 Antibody Abstract)|
|Background||The family of ribosomal S6 kinases (Rsks), designated Rsk-1 (MAPKAP kinase-1), Rsk-2 and Rsk-3, are intracellular serine/threonine kinases that are important signaling intermediates in response to a broad range of ligand activated receptor tyrosine kinases. A unique feature common to the members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. An additional Rsk protein, Rsk-4, shows a high level of homology to the three previously isolated members of the human Rsk family. Rsk-4 is most abundantly expressed in brain and kidney and plays a role in normal neuronal development. The 70 kDa family of ribosomal S6 kinases includes p70 S6 kinase and p70 S6 kinase beta, which are thought to have similar regulatory functions. MSK1 (also designated RLPK) is a novel Rskrelated protein, which, like the p90 Rsk family members, contains two non-identical complete kinase catalytic domains.Synonyms: 90 kDa ribosomal protein S6 kinase 6, RSK-4, Ribosomal S6 kinase 4, Ribosomal protein S6 kinase alpha-6, S6K-alpha-6, p90-RSK 6, p90RSK6, pp90RSK4|
|Molecular Weight||approx. 84 kDa|
Application DetailsProduct Details anti-RPS6KA6 Antibody Target Details RPS6KA6 Handling Images back to top
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-RPS6KA6 Antibody Target Details RPS6KA6 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-RPS6KA6 Antibody Target Details RPS6KA6 Application Details Handling back to top