anti-Human SIRT1 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended SIRT1 Antibody (supplied by: Log in to see )

Antigen
Sirtuin 1 (SIRT1) Antibodies
  • sirtuin 1
  • AA673258
  • SIR2L1
  • Sir2
  • Sir2a
  • Sir2alpha
  • sir2l1
  • sirtuin
  • SIR2
  • sirtuin 1
  • SIRT1
  • SRT1
  • LOC100349271
  • Sirt1
  • sirt1
Epitope
AA 20-60, pSer47
29
23
21
18
16
15
14
14
10
6
6
5
4
3
3
3
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
306
137
70
21
14
11
7
7
7
6
5
4
4
2
2
2
2
1
Host
Rabbit
205
87
27
6
3
Clonality
Polyclonal
Conjugate
This SIRT1 antibody is un-conjugated
17
14
10
7
7
6
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
255
132
88
67
60
51
42
39
36
7
6
5
4
2
2
2
2
2
1
1
Options
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Catalog No. ABIN745658
$ 329.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.569705 ABIN729853 IF (p) IHC (p) WB Rabbit IgG AA 192-242 Log in to see Polyclonal 3
11.569705 ABIN4353901 ELISA FACS ICC IF IHC IHC (p) WB Mouse IgG1 Log in to see 1F3 1
11.569705 ABIN4353903 ICC IF IHC IHC (p) WB Rabbit IgG Log in to see Polyclonal 3
11.569705 ABIN239843 IHC (p) IP WB Rabbit IgG C-Term Log in to see Polyclonal
1 ABIN372326 IHC (p) IP WB Rabbit IgG C-Term Log in to see Polyclonal
1 ABIN214144 IHC (p) WB Rabbit IgG AA 207-256 Log in to see Polyclonal
1 ABIN565071 IF IHC (p) ELISA WB Mouse IgG1 kappa AA 456-555, partial Log in to see 7B7 3
1 ABIN1109014 EIA FACS IF IHC (p) WB Mouse IgG1 Log in to see 1F3 2
1 ABIN746003 IF (p) IHC (p) WB Rabbit IgG AA 1-50, pSer27 Log in to see Polyclonal
1 ABIN1999249 ELISA IF IF/ICC IHC (p) Mouse IgG1 AA 193-747 Log in to see 3H10A10
1 ABIN614713 EIA IF IHC (p) WB Mouse IgG1 AA 456-555 Log in to see 7B7
1 ABIN1493902 IHC (p) ELISA WB Goat AA 577-590 Log in to see Polyclonal
1 ABIN679028 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal
1 ABIN1500927 ELISA FACS ICC IF IHC (p) WB Mouse IgG1 Log in to see 1F3
1 ABIN729862 IHC (p) WB HRP Rabbit IgG AA 192-242 Log in to see Polyclonal
1 ABIN745667 IHC (p) WB HRP Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal
1 ABIN729855 IHC (p) WB Biotin Rabbit IgG AA 192-242 Log in to see Polyclonal
1 ABIN745660 IHC (p) WB Biotin Rabbit IgG AA 20-60, pSer47 Log in to see Polyclonal
1 ABIN2476505 IF IHC (p) WB Mouse IgG1 AA 456-555 Log in to see 7B7
1 ABIN1723581 IF IHC (p) ELISA WB Mouse IgG1 kappa AA 456-555 Log in to see 7B7

General

Antigen Sirtuin 1 (SIRT1) Antibodies
Epitope AA 20-60, pSer47
(29), (23), (21), (18), (16), (15), (14), (14), (10), (6), (6), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(306), (137), (70), (21), (14), (11), (7), (7), (7), (6), (5), (4), (4), (2), (2), (2), (2), (1)
Host Rabbit
(205), (87), (27), (6), (3)
Clonality
Polyclonal
Conjugate This SIRT1 antibody is un-conjugated
(17), (14), (10), (7), (7), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(255), (132), (88), (67), (60), (51), (42), (39), (36), (7), (6), (5), (4), (2), (2), (2), (2), (2), (1), (1)
Pubmed 2 references available
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Product Details anti-SIRT1 Antibody

Target Details SIRT1 Application Details Handling ProductDetails: References for anti-SIRT1 antibody (ABIN745658) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human SirT1 around the phosphorylation site of Ser47
Isotype IgG

Target Details SIRT1

Product Details anti-SIRT1 Antibody Application Details Handling ProductDetails: References for anti-SIRT1 antibody (ABIN745658) Images back to top
Antigen
Alternative Name Sirt1 (SIRT1 Antibody Abstract)
Background

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Subcellular location: Cytoplasm, Nucleus

Synonyms: SIR2L1, NAD-dependent protein deacetylase sirtuin-1, hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2, SIRT1

Gene ID 23411
UniProt Q96EB6
Research Area Chromatin and Nuclear Signaling, Apoptosis/Necrosis, Proteases
Pathways MAPK Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling

Application Details

Product Details anti-SIRT1 Antibody Target Details SIRT1 Handling ProductDetails: References for anti-SIRT1 antibody (ABIN745658) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details ProductDetails: References for anti-SIRT1 antibody (ABIN745658) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

ProductDetails: References for anti-SIRT1 antibody (ABIN745658)

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details Handling Images back to top
Product cited in:

Suzuki, Bandoski, Bartlett: "Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling." in: Free radical biology & medicine, Vol. 89, pp. 369-378, 2015

Suzuki, Bartlett: "Sirtuin1 and autophagy protect cells from fluoride-induced cell stress." in: Biochimica et biophysica acta, Vol. 1842, Issue 2, pp. 245-55, 2014

Images

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details Handling ProductDetails: References for anti-SIRT1 antibody (ABIN745658) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Sirtuin 1 (SIRT1) (AA 20-60), (pSer47) antibody (ABIN745658) Formalin-fixed and paraffin embedded rat brain labeled with Anti-Phospho-SIRT1(Ser47)...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Sirtuin 1 (SIRT1) (AA 20-60), (pSer47) antibody (ABIN745658) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti-SI...