Browse our Legumain (LGMN) ELISA Kits

On are 27 Legumain (LGMN) ELISA Kits from 11 different suppliers available. Additionally we are shipping Legumain Antibodies (84) and Legumain Proteins (22) and many more products for this protein. A total of 145 Legumain products are currently listed.
AEP, AI746452, AU022324, cb173, cb460, delta vacuolar processing enzyme, DELTAVPE, lgmn, LGMN1, MGC64351, MGC88980, PRSC1, sb:cb173, wu:fa98g05, wu:fj92g08, zgc:76953
list all ELISA KIts Gene Name GeneID UniProt
LGMN 63865 Q9R0J8
LGMN 5641 Q99538
LGMN 19141 O89017

Legumain (LGMN) ELISA Kits by Reactivity

More ELISA Kits for Legumain Interaction Partners

Arabidopsis thaliana Legumain (LGMN) interaction partners

  1. at the early stage of seed development, deltaVPE is involved in cell death of limited cell layers, the purpose of which is to form a seed coat

Human Legumain (LGMN) interaction partners

  1. Data suggest that melanoma cells internalize/absorb cystatin C (show CST3 ELISA Kits) from culture media, leading to increased intracellular cystatin C (show CST3 ELISA Kits) levels; cystatin E/M (show CST6 ELISA Kits) is internalized as well but at modest rate due to down-regulation of cell migration; however, the effect of intracellular cystatin E/M (show CST6 ELISA Kits) on down-regulation of legumain activity is pronounced.

  2. AEP is activated and cleaves human alpha-synuclein (show SNCA ELISA Kits) at N103 in an age-dependent manner.

  3. AEP promotes activation of the PI3K (show PIK3CA ELISA Kits)-AKT (show AKT1 ELISA Kits) signaling pathway in prostate cancer cells.

  4. upregulation of legumain is associated with malignant behavior of uveal melanoma.

  5. Studies indicate that legumain, usually in lysosomes, is also found extracellularly and even translocates to the cytosol and the nucleus.

  6. legumain might play an important role in cervical cancer cell migration and invasion.

  7. Legumain appears to be involved in tumor development and deterioration.

  8. AEP acts as a delta-secretase, cleaving APP (show APP ELISA Kits) at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP (show APP ELISA Kits). AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.

  9. High legumain expression is associated with breast cancer.

  10. This unique feature was confirmed by the crystal structure of AEPpH4.5 (AEP was matured at pH 4.5 and crystallized at pH 8.5), in which the broken peptide bonds were religated and the structure was transformed back to its proenzyme form.

Cow (Bovine) Legumain (LGMN) interaction partners

  1. legumain and TIMP-2 (show TIMP2 ELISA Kits) mRNAs were up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy

Mouse (Murine) Legumain (LGMN) interaction partners

  1. This study showed that legumain may serve as a biomarker of disease, and that the occurrence of legumain-expressing macrophages in regions of acinar-to-ductal metaplasia suggests that this protease may influence reprogramming events that lead to inflammation-induced pancreatic cancer.

  2. AEP acts as a delta-secretase, cleaving APP (show APP ELISA Kits) at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP (show APP ELISA Kits). AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.

  3. results suggest that legumain expression and activation and cleavage of annexin A2 (show ANXA2 ELISA Kits) are regulated by DJ-1 (show PARK7 ELISA Kits) through p53 (show TP53 ELISA Kits)

  4. AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.

  5. TDP-43 (show TARDBP ELISA Kits) is cleaved by AEP in brain.

  6. TLR7 (show TLR7 ELISA Kits) requires a proteolytic cleavage by AEP to generate a C-terminal fragment competent for signaling.

  7. We identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (ICAM1 (show ICAM1 ELISA Kits)), and ras-related C3 botulinum toxin substrate 2 (RAC2 (show RAC2 ELISA Kits)), among others, in an invasive pre-B-cell line that produced leukemia in NOD-SCID (show PRKDC ELISA Kits) mice

  8. AEP is required for normal protein catabolism by PTCs, and its loss induces proliferative and other abnormalities in the murine kidney, at least in part through defective regulation of the EGF receptor (show EGFR ELISA Kits)

  9. Immunohistochemical analyses revealed the expression of legumain in Iba1 (show AIF1 ELISA Kits)(+) microglial cells and glial fibrillary acidic protein (show GFAP ELISA Kits)-positive astrocytes of the peri (show POSTN ELISA Kits)-infarct area in mice after transient occlusion of the middle cerebral artery.

  10. AEP has a pivotal role in the endosomal/lysosomal degradation system

Legumain (LGMN) Antigen Profile

Antigen Summary

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Alternative names and synonyms associated with Legumain (LGMN)

  • legumain-like (LOC100053265) Elisa Kit
  • legumain (lgmn) Elisa Kit
  • legumain (LGMN) Elisa Kit
  • delta vacuolar processing enzyme/legumain (DELTA-VPE) Elisa Kit
  • Legumain (Mboo_1489) Elisa Kit
  • Legumain (Odosp_3582) Elisa Kit
  • Legumain (lgmn) Elisa Kit
  • legumain (Lgmn) Elisa Kit
  • AEP Elisa Kit
  • AI746452 Elisa Kit
  • AU022324 Elisa Kit
  • cb173 Elisa Kit
  • cb460 Elisa Kit
  • delta vacuolar processing enzyme Elisa Kit
  • DELTAVPE Elisa Kit
  • lgmn Elisa Kit
  • LGMN1 Elisa Kit
  • MGC64351 Elisa Kit
  • MGC88980 Elisa Kit
  • PRSC1 Elisa Kit
  • sb:cb173 Elisa Kit
  • wu:fa98g05 Elisa Kit
  • wu:fj92g08 Elisa Kit
  • zgc:76953 Elisa Kit

Protein level used designations for Legumain (LGMN) ELISA Kits

legumain , Legumain , asparaginyl endopeptidase , protease, cysteine 1 , protease, cysteine, 1 (legumain) , cysteine protease 1 , preprolegumain , protease, cysteine, 1

100053265 Equus caballus
379601 Xenopus laevis
406625 Danio rerio
423418 Gallus gallus
448252 Xenopus (Silurana) tropicalis
821565 Arabidopsis thaliana
5410409 Methanoregula boonei 6A8
10255359 Odoribacter splanchnicus DSM 220712
100306856 Salmo salar
63865 Rattus norvegicus
5641 Homo sapiens
480232 Canis lupus familiaris
281281 Bos taurus
19141 Mus musculus
100173793 Pongo abelii
Selected quality suppliers for Legumain (LGMN) ELISA Kits
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