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These results showed that Asparaginyl endopeptidase could promote invasion and metastasis by modulating epithelial-to-mesenchymal transition.
Our data suggest that altered proteolytic activity of legumain in the bone microenvironment contributes to decreased bone mass in postmenopausal osteoporosis.
Legumain is increased in both plasma and plaques of patients with carotid stenosis and might be a new and early biomarker of atherosclerosis.
Data suggest that melanoma cells internalize/absorb cystatin C (show CST3 ELISA Kits) from culture media, leading to increased intracellular cystatin C (show CST3 ELISA Kits) levels; cystatin E/M (show CST6 ELISA Kits) is internalized as well but at modest rate due to down-regulation of cell migration; however, the effect of intracellular cystatin E/M (show CST6 ELISA Kits) on down-regulation of legumain activity is pronounced.
AEP is activated and cleaves human alpha-synuclein at N103 in an age-dependent manner.
AEP promotes activation of the PI3K (show PIK3CA ELISA Kits)-AKT (show AKT1 ELISA Kits) signaling pathway in prostate cancer cells.
upregulation of legumain is associated with malignant behavior of uveal melanoma.
Studies indicate that legumain, usually in lysosomes, is also found extracellularly and even translocates to the cytosol and the nucleus.
legumain might play an important role in cervical cancer cell migration and invasion.
Legumain appears to be involved in tumor development and deterioration.
This study showed that legumain may serve as a biomarker of disease, and that the occurrence of legumain-expressing macrophages in regions of acinar-to-ductal metaplasia suggests that this protease may influence reprogramming events that lead to inflammation-induced pancreatic cancer.
AEP acts as a delta-secretase, cleaving APP (show APP ELISA Kits) at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP (show APP ELISA Kits). AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.
results suggest that legumain expression and activation and cleavage of annexin A2 (show ANXA2 ELISA Kits) are regulated by DJ-1 (show PARK7 ELISA Kits) through p53 (show TP53 ELISA Kits)
AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.
TDP-43 (show TARDBP ELISA Kits) is cleaved by AEP in brain.
TLR7 (show TLR7 ELISA Kits) requires a proteolytic cleavage by AEP to generate a C-terminal fragment competent for signaling.
We identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (ICAM1 (show ICAM1 ELISA Kits)), and ras-related C3 botulinum toxin substrate 2 (RAC2 (show RAC2 ELISA Kits)), among others, in an invasive pre-B-cell line that produced leukemia in NOD-SCID (show PRKDC ELISA Kits) mice
AEP is required for normal protein catabolism by PTCs, and its loss induces proliferative and other abnormalities in the murine kidney, at least in part through defective regulation of the EGF receptor (show EGFR ELISA Kits)
Immunohistochemical analyses revealed the expression of legumain in Iba1 (show AIF1 ELISA Kits)(+) microglial cells and glial fibrillary acidic protein (show GFAP ELISA Kits)-positive astrocytes of the peri (show POSTN ELISA Kits)-infarct area in mice after transient occlusion of the middle cerebral artery.
legumain and TIMP-2 (show TIMP2 ELISA Kits) mRNAs were up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy
at the early stage of seed development, deltaVPE is involved in cell death of limited cell layers, the purpose of which is to form a seed coat
The LGMN and CST6 (show CST6 ELISA Kits) system at the maternal-fetal interface may play an important role in the establishment and maintenance of pregnancy in pigs.
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
, cysteine protease 1
, protease, cysteine 1
, protease, cysteine, 1 (legumain)
, protease, cysteine, 1