Browse our LRP2 Proteins (LRP2)

Full name:
Low Density Lipoprotein Receptor-Related Protein 2 Proteins (LRP2)
On www.antibodies-online.com are 7 Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) Proteins from 3 different suppliers available. Additionally we are shipping LRP2 Antibodies (64) and LRP2 Kits (17) and many more products for this protein. A total of 88 LRP2 products are currently listed.
Synonyms:
AI315343, AW536255, D230004K18Rik, DBS, Gp330, im:680590, lrp2, Megalin
list all proteins Gene Name GeneID UniProt
LRP2 4036 P98164
LRP2 14725 A2ARV4
Rat LRP2 LRP2 29216 P98158

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LRP2 Proteins (LRP2) by Origin

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More Proteins for LRP2 Interaction Partners

Zebrafish Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) interaction partners

  1. Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.

  2. These studies implicate altered Lrp2-mediated homeostasis as important for myopia and other risk factors for glaucoma.

Rabbit Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) interaction partners

  1. Megalin mediates transepithelial albumin (show ALB Proteins) clearance from the alveolar space of intact rabbit lungs

  2. low-level LPS (show IRF6 Proteins)-mediated TNF-alpha (show TNF Proteins)-ERK1/2 signaling pathway is involved in downregulation of megalin expression in IRPTCs.

Human Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) interaction partners

  1. we discovered one novel locus (LRP2; most significant single nucleotide polymorphism rs12988804) that reached genome-wide significance in predicting relapse risk (HR=2.18, p=3.30x10(-8)).

  2. miR (show MLXIP Proteins)-148b directly down-regulates renal megalin expression.

  3. Exocytosis-mediated urinary C-megalin excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin-mediated lysosomal dysfunction in proximal tubules.

  4. The studies suggest that impaired endocytosis of megalin/cubilin (show CUBN Proteins) ligands, hemoglobin (show HBB Proteins) and albumin (show ALB Proteins), rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients.

  5. VDR (show CYP27B1 Proteins) and MEGALIN gene variations can alter age-related cognitive trajectories differentially between men and women among African American urban adults, specifically in global mental status and domains of verbal fluency, visual/working memory, and executive function.

  6. the main role for placental megalin is not to mediate uptake of nutrients from the maternal bloodstream; results point toward novel and complex functions for megalin in the cytotrophoblasts.

  7. specific miRNA-146a regulation may contribute to Alzheimer's disease by downregulating the Lrp2/Akt (show AKT1 Proteins) pathway

  8. abundances of megalin and Dab2 (show DAB2 Proteins) (p = 0.046) were reduced in infected placentas from women with LBW deliveries

  9. homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 and TSPYL2 (show TSPYL2 Proteins) genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability

  10. The megalin expression appears to vary inversely with gestational age with the greatest expression noted in the most premature samples. Age-dependent differences in placental megalin may therefore influence fetal exposure.

Mouse (Murine) Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) interaction partners

  1. This study evaluated the role of transcobalamin (TC), the transcobalamin receptor (CD320 (show CD320 Proteins)) , and megalin in various tissues during pregnancy.

  2. miR (show MLXIP Proteins)-148b negatively regulates megalin expression in unilateral ureteral obstruction-induced kidney injury.

  3. Exocytosis-mediated urinary C-megalin excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin-mediated lysosomal dysfunction in proximal tubules.

  4. study reveals a cross talk between ATR signaling and DPP4 (show DPP4 Proteins) activation in the regulation of megalin and underscores the significance of targeting DPP4 (show DPP4 Proteins) in the prevention of obesity related kidney injury progression.

  5. LRP2 plays a crucial role in cardiovascular development in mice.

  6. Foxg1 (show FOXG1 Proteins)-Cre mediated Lrp2 inactivation in developing mouse neural retina, ciliary and retinal pigment epithelia is a model of congenital high myopia

  7. megalin-deficient mice may provide a valuable model for future studies of megalin in ocular physiology and pathology.

  8. LRP2 is essential for cellular folate uptake in the developing neural tube, a crucial step for proper neural tube closure.

  9. we have identified hypothalamic clusterin (show CLU Proteins) as a novel anorexigenic molecule that can potentiate central leptin (show LEP Proteins) activity.

  10. Multiligand endocytic receptor megalin may be involved in AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells.

LRP2 Protein Profile

Protein Summary

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

Alternative names and synonyms associated with LRP2

  • low density lipoprotein receptor-related protein 2 (LRP2)
  • low density lipoprotein receptor-related protein 2a (lrp2a)
  • low-density lipoprotein receptor-related protein 2 (LRP2.3)
  • low density lipoprotein receptor-related protein 2 (lrp2)
  • low-density lipoprotein receptor-related protein 2-like (LOC100183506)
  • low density lipoprotein receptor-related protein 2 (Lrp2)
  • AI315343 protein
  • AW536255 protein
  • D230004K18Rik protein
  • DBS protein
  • Gp330 protein
  • im:680590 protein
  • lrp2 protein
  • Megalin protein

Protein level used designations for LRP2

low density lipoprotein-related protein 2 , gp330b , low-density lipoprotein receptor-related protein 2 , megalin , low density lipoprotein receptor-related protein 2 , low-density lipoprotein receptor-related protein 2-like , Heymann nephritis antigen homolog , LRP-2 , calcium sensor protein , glycoprotein 330 , gp330

GENE ID SPECIES
459713 Pan troglodytes
478781 Canis lupus familiaris
568184 Danio rerio
589778 Strongylocentrotus purpuratus
7232953 Branchiostoma floridae
100024150 Monodelphis domestica
100062836 Equus caballus
100126618 Xenopus laevis
100183506 Ciona intestinalis
100346275 Oryctolagus cuniculus
100403066 Callithrix jacchus
100455598 Pongo abelii
100475386 Ailuropoda melanoleuca
100489914 Xenopus (Silurana) tropicalis
100543626 Meleagris gallopavo
100558696 Anolis carolinensis
100591561 Nomascus leucogenys
4036 Homo sapiens
14725 Mus musculus
29216 Rattus norvegicus
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