Browse our anti-ROCK2 (ROCK2) Antibodies

Full name:
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 Antibodies (ROCK2)
On www.antibodies-online.com are 165 rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) Antibodies from 31 different suppliers available. Additionally we are shipping ROCK2 Kits (25) and ROCK2 Proteins (10) and many more products for this protein. A total of 209 ROCK2 products are currently listed.
Synonyms:
B230113H15Rik, mKIAA0619, Rho-kinase, ROCK-II, ROCK2, Rock2m, rocka-a, ROK, rok2, ROKalpha, xROK
list all antibodies Gene Name GeneID UniProt
ROCK2 19878 P70336
ROCK2 25537 Q62868
ROCK2 9475 O75116

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Most Popular Reactivities for anti-ROCK2 (ROCK2) Antibodies

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anti-Mouse (Murine) ROCK2 Antibodies:

anti-Rat (Rattus) ROCK2 Antibodies:

anti-Human ROCK2 Antibodies:

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Top referenced anti-ROCK2 Antibodies

  1. Dog (Canine) Monoclonal ROCK2 Primary Antibody for IF, IP - ABIN968070 : Adachi, Vita, Sannohe, Stafford, Alam, Kayaba, Chihara: The functional role of rho and rho-associated coiled-coil forming protein kinase in eotaxin signaling of eosinophils. in Journal of immunology (Baltimore, Md. : 1950) 2001 (PubMed)
    Show all 5 references for 968070

  2. Human Polyclonal ROCK2 Primary Antibody for IF (p), IHC (p) - ABIN673359 : Wang, Zhang, Wang, Zhang, Mao, Zhuang, Tang, Luo, Zhou, Zhang: Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor--a signaling pathway. in The international journal of biochemistry & cell biology 2013 (PubMed)
    Show all 2 references for 673359

  3. Human Polyclonal ROCK2 Primary Antibody for ELISA, WB - ABIN1450779 : Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005 (PubMed)
    Show all 2 references for 1450779

  4. Human Polyclonal ROCK2 Primary Antibody for IHC, IHC (p) - ABIN4350923 : Mikami, Yoshida, Sawada, Esaki, Yasumura, Ono: Inhibition of Rho-associated kinases disturbs the collective cell migration of stratified TE-10 cells. in Biological research 2015 (PubMed)
    Show all 2 references for 4350923

  5. Human Polyclonal ROCK2 Primary Antibody for IHC (p), WB - ABIN1108892 : Thumkeo, Keel, Ishizaki, Hirose, Nonomura, Oshima, Oshima, Taketo, Narumiya: Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. in Molecular and cellular biology 2003 (PubMed)
    Show all 2 references for 1108892

  6. Human Polyclonal ROCK2 Primary Antibody for IP, WB - ABIN152024 : Mattaliano, Wooters, Shih, Paulsen: ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production. in American journal of physiology. Cell physiology 2010 (PubMed)
    Show all 2 references for 152024

  7. Human Monoclonal ROCK2 Primary Antibody for IF, IHC (p) - ABIN522961 : Chen, Liu, Huang, Chiou: Vascular hyperpermeability in response to inflammatory mustard oil is mediated by Rho kinase in mice systemically exposed to arsenic. in Microvascular research 2011 (PubMed)

  8. Human Polyclonal ROCK2 Primary Antibody for IP, PLA - ABIN152025 : Shum, Da Silva, Belleannée, McKee, Brown, Breton: Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells. in American journal of physiology. Cell physiology 2011 (PubMed)

More Antibodies against ROCK2 Interaction Partners

Xenopus laevis rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.

  2. Data demonstrate a direct relationship between SHP-2(N308D) and ROCK activation in the developing heart.

  3. Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.

Zebrafish rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. The findings of the present study indicate that miR (show MYLIP Antibodies)-142-3p plays a critical role in hematopoiesis, cardiogenesis, and somitegenesis in the early stage of mesoderm formation via regulation of Rock2a.

  2. Data show that Rock2 acts as a negative regulator of the TGFbeta (show TGFB1 Antibodies) signaling pathway.

Mouse (Murine) rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. The effect of Smad4 (show SMAD4 Antibodies) was at least partially mediated by the downstream effectors Syk (show SYK Antibodies) and ROCK2 transcription in megakaryocytes.

  2. Here we describe the generation of a gene-targeted mouse line that enables CRE-inducible expression of a conditionally-active fusion between the ROCK2 kinase domain and the hormone-binding domain of a mutated estrogen receptor (show ESR1 Antibodies) (ROCK2:ER). This two-stage system of regulation allows for tissue-selective expression of the ROCK2:ER fusion protein, which then requires administration of estrogen analogues

  3. The results of the present study verify that ROCKII participates in the loss of DA neurons induced by MPTP (show PTPN2 Antibodies) and suggest that ROCKII inhibition may be a promising therapeutic target for PD.

  4. These results indicate that tensile force induces in vivo gene expression associated with vascularization early in tensile-force-induced sutural bone formation. Moreover, the early induction of Vegf (show VEGFA Antibodies) gene expression is regulated by CTGF (show CTGF Antibodies) and ROCK2.

  5. While the loss of either Rock1 (show ROCK1 Antibodies) or Rock2 had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 (show ROCK1 Antibodies) and Rock2 have been genetically deleted.

  6. Inhibition of the RhoA (show RHOA Antibodies)/Rock2 kinase pathway prevents lipopolysaccharide-induced hyperalgesia and the release of TNF-alpha (show TNF Antibodies) and IL-1beta (show IL1B Antibodies) in the mouse spinal cord.

  7. found that cigarette smoke leads to decreased ROCK2 activation and IRF4 (show IRF4 Antibodies) phosphorylation in T cells

  8. Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

  9. Results suggest that Rho-associated, coiled-coil containing protein kinase (ROCK) inhibitors fasudil may be an emerging therapeutic option for targeting cancer vasculogenic mimicry (VM).

  10. Lin28a (show LIN28A Antibodies) protects against DCM through PKA/ROCK2 dependent pathway.

Human rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. ICAP-1 (show ITGB1BP1 Antibodies) monoubiquitylation helps in switching from ROCK2-mediated to MRCKalpha-mediated cell contractility.

  2. BCR-ABL-dependent ROCK, but not TK, is involved in CD1d downregulation. We propose that ROCK, which is most likely activated by the DH/PH domain of BCR-ABL, mediates iNKT-cell immune subversion in chronic myeloid leukaemia (CML) patients by downregulating CD1d expression on CML mDCs.

  3. this study shows that ulinastatin (show AMBP Antibodies) inhibites the hyperpermeability of vascular endothelial cells induced by TNF-alpha (show TNF Antibodies), and that this inhibitory effect may be related to the RhoA (show RHOA Antibodies)/ROCK2 signaling pathway

  4. Taken together, these results suggest that this newly identified Rock2-beta-catenin (show CTNNB1 Antibodies)/TCF4 (show TCF4 Antibodies)-SCARA5 (show SCARA5 Antibodies) axis will provide novel insight into the understanding of the regulatory mechanisms of proliferation in human RCC (show XRCC1 Antibodies).

  5. Panax notoginseng saponins provide neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1 (show NEUROG1 Antibodies), RhoA (show RHOA Antibodies), and ROCK2.

  6. The positive rates of Rock2 protein in normal esophageal epithelium tissue was 12.3% and in esophageal carcinomas tissues was 56.5%. The expression of Rock2 protein was related with vascular invasion and there was no significant difference between the expression of Rock2 protein and ESCC patients' tumor location, differentiation, T stage, and lymph node metastases.

  7. There are 2 isoforms: ROCK1 (show ROCK1 Antibodies) and ROCK2. They have different functions in different types of cells and tissues. There is growing evidence that ROCKs contribute to the development of cardiovascular diseases, including cardiac fibrosis, hypertrophy, and subsequent heart failure.

  8. a soft extracellular matrix causes downregulation of ROCK2 expression, which drives resistance to chemotherapy by repressing p53 (show TP53 Antibodies) activation.

  9. Data suggest that Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor Y-27632 may be therapeutically useful in tongue squamous cell carcinoma (TSCC).

  10. Significant associations between ROCK1 (show ROCK1 Antibodies), ROCK2, RhoA (show RHOA Antibodies) and RhoC (show RHOC Antibodies) gene polymorphisms and systemic sclerosis were demonstrated.

Pig (Porcine) rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Results indicate that ROCK1 (show ROCK1 Antibodies) and ROCK2 may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.

  2. ROCK2 plays a pivotal role in generating the intrinsic circadian rhythm of vascular contractility by receiving a cue from RORalpha.

  3. It is highly possible that Rho-kinase (show ROCK1 Antibodies) plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase (show ROCK1 Antibodies) is not involved in endothelial regeneration after vascular injury.

Cow (Bovine) rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) interaction partners

  1. Rho-kinase (show ROCK1 Antibodies) analysis of coiled-coil association of the RhoA (show RHOA Antibodies)-binding domain

  2. RhoA/Rho-kinase pathway is an important component of TGF-beta-induced effects on endothelial myosin light chain phosphorylation, cytoskeletal reorganization, and barrier integrity.

  3. nucleus-localized ROCK2 targets p300 for phosphorylation to regulate its acetyltransferase activity

ROCK2 Antigen Profile

Antigen Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

Alternative names and synonyms associated with ROCK2

  • Rho-associated, coiled-coil containing protein kinase 2 (rock2) antibody
  • rho-associated, coiled-coil containing protein kinase 2a (rock2a) antibody
  • Rho-associated, coiled-coil containing protein kinase 2 (ROCK2) antibody
  • Rho-associated coiled-coil containing protein kinase 2 (Rock2) antibody
  • Rho-associated coiled-coil containing protein kinase 2-like (LOC100346837) antibody
  • Rho-associated, coiled-coil containing protein kinase 2 (Rock2) antibody
  • B230113H15Rik antibody
  • mKIAA0619 antibody
  • Rho-kinase antibody
  • ROCK-II antibody
  • ROCK2 antibody
  • Rock2m antibody
  • rocka-a antibody
  • ROK antibody
  • rok2 antibody
  • ROKalpha antibody
  • xROK antibody

Protein level used designations for ROCK2

Rho-associated kinase alpha , rho-associated protein kinase 2 , rho-associated, coiled-coil containing protein kinase 2 , Rho-associated, coiled-coil containing protein kinase 2 , rho-associated protein kinase 2-like , Rho-associated coiled-coil forming kinage 2 , p164 ROCK-2 , rho-associated, coiled-coil-containing protein kinase 2 , rho-associated, coiled-coil-containing protein kinase II , ROKalpha , Rho-associated coiled-coil forming kinase 2 , RhoA - binding serine/threosine kinase alpha (ROK - alpha) , p150 ROK-alpha , rhoA-binding kinase 2 , Rho-kinase alpha

GENE ID SPECIES
394289 Xenopus laevis
317747 Danio rerio
470307 Pan troglodytes
708444 Macaca mulatta
100221127 Taeniopygia guttata
100294663 Ovis aries
100461801 Pongo abelii
100578506 Apis mellifera
100585294 Nomascus leucogenys
19878 Mus musculus
25537 Rattus norvegicus
100346837 Oryctolagus cuniculus
9475 Homo sapiens
374182 Gallus gallus
482970 Canis lupus familiaris
397445 Sus scrofa
282041 Bos taurus
100713798 Cavia porcellus
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