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This study showed that LPIN1 knockdown blocks phospholipid synthesis and changes membrane lipid compositions, and that lipin-1 knockdown significantly inhibits tumor growth in vivo using an orthotopic xenograft breast mouse model.
The novel insights into the regulation of human Lipin-1 stability will be useful in planning further studies to elucidate its metabolic processes.
It seems that a new signaling axis, SIRT1 (show SIRT1 Proteins)-SFRS10 (show TRA2B Proteins)-LPIN1 axis, acting in the pathogenesis of alcoholic fatty liver disease exists.
Consistent with these observations, LPIN1 levels were positively correlated with IRS1 (show IRS1 Proteins) expression in human breast cancer. Thus, our results indicate a mechanism by which IRS1 (show IRS1 Proteins) expression is increased in breast cancer, and LPIN1 may be a promising drug target for anticancer therapy
LPIN1 is upregulated in non-alcoholic fatty liver disease. Up-regulation of miR (show MLXIP Proteins)-122 can trigger the compensatory response of LPIN1 and CTDNEP1 (show DULLARD Proteins) in hepatosteatosis.
lipin-1-mediated downregulation of p21 (show CDKN1A Proteins) is critical for the progress of keratinocyte differentiation
lipin-1 has a critical role in the regulation of macrophage inflammatory responses to modified-LDL
Results of our study suggest that rs2716610: C>T polymorphism of LPIN1 gene could have a protective effect against development of metabolic syndrome, while rs11693809: C>T might affect a glucose control in patients with MS.
Lipin-1 controls main cellular processes involved in cancer progression and that its targeting, alone or in combination with other treatments, could open new avenues in anticancer therapy.
Lipin1beta might play a role in the pathogenesis of insulin (show INS Proteins) resistance in gestational diabetes mellitus
Time course analysis demonstrated that the adipogenic 'hub', sampled by PPARgamma (show PPARG Proteins) and Lpin1, undergoes orchestrated reorganization during adipogenesis.
Our findings provide new insights into the physiological roles of hepatic Lipin1 in systemic energy homeostasis, and suggest that the moderate inactivation of hepatic Lipin1 represents a promising approach for preventing the development of obesity.
c-fos has a role in increasing the catalytic efficiency of lipin 1 beta
reveals a previously unknown role of lipin1 in skeletal muscle regeneration and expands our understanding of the cellular and molecular mechanisms underlying skeletal muscle regeneration
deficits in hepatic PAP (show ASAP1 Proteins) activity do not impair TG synthesis and accumulation
lipin-1 PAP (show ASAP1 Proteins) activity functions in autophagy to activate the PKD (show PRKD1 Proteins)-Vps34 (show PIK3C3 Proteins) cascade to promote autolysosome maturation.
The findings demonstrate an unanticipated role for lipin-1 as a mediator of macrophage proinflammatory activation and support a critical link between lipid biosynthesis and systemic inflammatory responses.
in addition to their roles during early adipogenesis, lipin1 and lipin2 (show LPIN2 Proteins) also have a role in lipid droplet biogenesis.
hepatic removal of lipin-1 in mice augmented ethanol-induced impairment of hepatic fatty acid oxidation and lipoprotein production, likely by way of deactivation of peroxisome proliferator-activated receptor gamma coactivator-1 alpha.
The lipin1 gene may have a crucial effect on body lipid accumulation in pigs.
Different genotypes of the Lpin1 gene were associated with percentage of leaf fat and intramuscular fat.
The results of this study suggest that suggest that SLC27A6, ACSL1 (show Acsl1 Proteins), FABP3 (show FABP3 Proteins), AGPAT6 (show AGPAT6 Proteins), and LPIN1 coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary.
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their full-length structures have not been determined.
, phosphatidate phosphatase LPIN1-like
, phosphatidate phosphatase LPIN1
, fatty liver dystrophy protein