Browse our anti-GJA1 (GJA1) Antibodies

Full name:
anti-Gap Junction Protein, alpha 1, 43kDa Antibodies (GJA1)
On www.antibodies-online.com are 306 Gap Junction Protein, alpha 1, 43kDa (GJA1) Antibodies from 31 different suppliers available. Additionally we are shipping GJA1 Kits (65) and GJA1 Proteins (10) and many more products for this protein. A total of 395 GJA1 products are currently listed.
Synonyms:
AI118175, AU042049, AVSD3, AW546267, Cnx32, Cnx43, Cnx46, connexin43, connexin 43, Cx32, CX43, cx43a1, Cx43alpha1, Cx46, DFNB38, Gja-1, Gja-3, gja1, gja1-A, GJAL, Gjb-1, HLHS1, HSS, Npm1, ODDD, zfCx43.3
list all antibodies Gene Name GeneID UniProt
GJA1 14609 P23242
Anti-Rat GJA1 GJA1 24392 P08050
GJA1 2697 P17302

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Top referenced anti-GJA1 Antibodies

  1. Human Polyclonal GJA1 Primary Antibody for IHC (p), WB - ABIN388369 : Li, Zhang, Jiao, Zou: Knockdown of microRNA-181 by lentivirus mediated siRNA expression vector decreases the arrhythmogenic effect of skeletal myoblast transplantation in rat with myocardial infarction. in Microvascular research 2009 (PubMed)
    Show all 9 references for 388369

  2. Chicken Monoclonal GJA1 Primary Antibody for IHC (f), IF - ABIN967717 : Giepmans, Hengeveld, Postma, Moolenaar: Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for 967717

  3. Human Polyclonal GJA1 Primary Antibody for EIA, IHC (p) - ABIN357085 : Spinella, Rosanò, Di Castro, Nicotra, Natali, Bagnato: Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for 357085

  4. Dog (Canine) Polyclonal GJA1 Primary Antibody for IF (p), IHC (p) - ABIN671451 : Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014 (PubMed)
    Show all 2 references for 671451

  5. Human Polyclonal GJA1 Primary Antibody for IHC (p), WB - ABIN197018 : Solan, Fry, TenBroek, Lampe: Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation. in Journal of cell science 2003 (PubMed)
    Show all 2 references for 197018

  6. Human Polyclonal GJA1 Primary Antibody for ELISA, WB - ABIN1532837 : Boengler, Schulz, Heusch: Connexin 43 signalling and cardioprotection. in Heart (British Cardiac Society) 2006 (PubMed)

  7. Cow (Bovine) Polyclonal GJA1 Primary Antibody for WB - ABIN2774852 : Feller, Wood, Sluiter, Noffke, Raubenheimer, Lemmer, van Rensburg: Report of a black South African child with oculodentodigital dysplasia and a novel GJA1 gene mutation. in American journal of medical genetics. Part A 2008 (PubMed)

  8. Human Polyclonal GJA1 Primary Antibody for IHC, ELISA - ABIN1531561 : Fishman, Eddy, Shows, Rosenthal, Leinwand: The human connexin gene family of gap junction proteins: distinct chromosomal locations but similar structures. in Genomics 1991 (PubMed)

  9. Cow (Bovine) Polyclonal GJA1 Primary Antibody for WB - ABIN2774853 : Gellhaus, Dong, Propson, Maass, Klein-Hitpass, Kibschull, Traub, Willecke, Perbal, Lye, Winterhager: Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against GJA1 Interaction Partners

Zebrafish Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal.

  2. serpinh1b is molecularly and functionally downstream of cx43. The gene serpinh1b codes for a protein called Hsp47, a molecular chaperone (show HSP90AA1 Antibodies) responsible for proper folding of procollagen molecules.

  3. Hapln1a (show HAPLN1 Antibodies)-ECM (show MMRN1 Antibodies) stabilizes the secreted growth factor (show WNT2 Antibodies) Semaphorin3d (Sema3d (show SEMA3D Antibodies)), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration.

  4. Hapln1a (show HAPLN1 Antibodies) has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton

  5. Sema3d (show SEMA3D Antibodies) functions in a common molecular pathway with Cx43 cell proliferation and joint formation

  6. Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL (show COL6A1 Antibodies)) exhibited osteogenic characteristics, in which Cx43 played an important role.

  7. Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role.

  8. Data demonstrate a cross-talk between IGF-1R (show IGF1R Antibodies) and AT-1R in AT-II and IGF-1 (show IGF1 Antibodies)-induced Cx43 expression in SV SMCs involving Erk 1 (show MAPK3 Antibodies)/2 and downstream activation of the AP-1 (show JUN Antibodies) transcription factor.

  9. Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45 (show GJC1 Antibodies).

  10. Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis.

Rabbit Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. These findings indicated that Cx43/miR (show MYLIP Antibodies)-206 is involved in the pathogenesis of early stage steroid-induced avascular necrosis of the femoral head.

  2. Gap junction enhancer AAP10 could attenuate the pro-arrhythmic effect of lysophosphatidic acid, probably by downregulating myocardial nonphosphorylated Cx43 expression.

  3. Ischemic postconditioning protected the heart from I/R injury by attenuating I/R induced decrease of mitochondria Cx43 expression.

  4. In addition to Cx43 dephosphorylation, downregulation of Cx43 plays an essential role in reduced cell coupling in the failing rabbit heart

Mouse (Murine) Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Blocking of connexin32 (show GJB1 Antibodies) or connexin43 hemichannels decreased serum levels of pro-inflammatory cytokines, and reduced acetaminophen-induced liver injury.

  2. deletion of connexin 43 (Cx43, also known as GJA1) in astrocytes inhibits OPC proliferation by decreasing matrix glucose levels without impacting on OPC hemichannel properties, a process that also occurs in corpus callosum from acute brain slices.

  3. Relative to Gja1(+/-) controls, male Gja1(-/K258Stop) mice have a cortical bone phenotype that is remarkably similar to those reported for deletion of the entire Cx43 gene in osteoblasts.

  4. S368 of connexin 43 (also known as GJA1) is phosphorylated on gap junctions and connexosomes, whereas connexin 43 residue S262 is phosphorylated only on some connexosomes.

  5. a plaque accretion defect as the primary manifestation of myosin VI (show MYO6 Antibodies) loss in Cx43 homeostasis, is reported.

  6. Findings demonstrate that spinal cord injury activates astrocyte sigma-1 receptors leading to increases in the expression of the gap junction protein, connexin 43 and astrocyte activation in the lumbar dorsal horn, and ultimately contribute to the induction of bilateral below-level mechanical allodynia.

  7. beige (show LYST Antibodies) adipocytes display an increased cell-to-cell coupling via connexin 43 (Cx43) gap junction channels.

  8. intermittent hypoxia (but not sleep fragmentation) causes reductions and remodeling of atrial Cx40 (show GJA5 Antibodies) and Cx43.

  9. the expression of Cx43 is specifically required in lymphatic endothelial cells for normal development of Lymphatic valves.

  10. This study showed that Gja1 may act downstream of cAMP-PKA signal to mediate the effects of Acvr1 (show ACRV1 Antibodies) on the differentiation of uterine stromal cells through targeting Hand2 (show HAND2 Antibodies).

Guinea Pig Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. The localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding spiral ganglion cell bodies in man and guinea pig, were analyzed.

  2. CX43 is therefore essential for the maintenance of spontaneous slow wave activity and subsequent contractile activity in the guinea pig prostate gland.

Cow (Bovine) Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis.

  2. Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration.

  3. RhoA (show RHOA Antibodies) appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress

  4. Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.

  5. Human TGF-beta1 (show TGFB1 Antibodies) induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells

  6. Increased degradation of Cx43 and reduction of intracellular communication through gap junctions in high glucose may be of physiological importance by contributing to endothelial cell dysfunction.

  7. intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26 (show GJB2 Antibodies), Cx32 (show GJB1 Antibodies), and Cx43

  8. CBN (show CALB1 Antibodies) blocks junctional communication and modulates Cx43 expression in BAEC. These results suggest a feedback mechanism for control of connexin expression based on junctional patency.

  9. Results describe the effect of suppression of connexin 43 and E-cadherin (show CDH1 Antibodies) on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.

Human Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Connexin 43 expression is increased in human fetal membrane defects after fetoscopic surgery compared to controls, with preferential distribution in the fibroblast layer compared with the epithelial layer.

  2. Results show stark differences in gap junction plaque formation, gap junctional intercellular communication, Cx43 phosphorylation, and hemichannel activity among Cx43 variants, as well as subtle differences in myofibroblast differentiation.

  3. These observations point to Cx43 as a novel profibrotic factor in asthma progression.

  4. results show that Cx43 expression is reduced in the diabetic retinas and Cx43 reduction is associated with increased vascular cell death; findings suggest that diabetes decreases retinal Cx43 expression and that the development of pericyte loss and acellular capilaries is associated with reduced Cx43 expression in diabetic retinopathy

  5. Reduced expression of Cx26 (show GJB2 Antibodies) and Cx43 is implicated in the pathophysiology of colonic dysmotility in the aganglionic bowel as well as, in the case of Cx26 (show GJB2 Antibodies), the ganglionic bowel in Hirschsprung's disease.

  6. Results suggest polymorphisms of Cx37 (show GJA4 Antibodies) rs1630310 and Cx43 rs1925223 genes may be associated with the pathogenesis of essential hypertension.

  7. The Cx43 is the most prominent gap junction protein in the heart, cardiomyocyte-differentiated stem cells have been studied intensely. Cx43 expression was detected at mRNA and protein level in human cord-blood-derived induced pluripotent stem cells .

  8. Human deltoid muscle biopsies of 5 Chilean dysferlinopathy patients exhibited the presence of muscular connexins (Cx40.1, Cx43 and Cx45 (show GJC1 Antibodies)).

  9. endogenous osteocyte Cx43 hemichannels emerge as important and promising therapeutic targets for the prevention of bone metastases and/or clinical treatment of bone-metastasized breast cancers

  10. The results suggest that Osterix (show SP7 Antibodies) plays an important role in increasing BMP- 4 (show BMP4 Antibodies)-induced Cx43 activity.

Pig (Porcine) Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Data show that connexin 43 (Cx43) is localized in the ooplasmic membrane through zona pellucidae and its level changes over time during culture in porcine oocytes.

  2. The effects of flutamide on connexin 43 expression in porcine placenta and uterus throughout pregnancy are reported.

  3. we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.

  4. The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 (show CDK4 Antibodies) gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.

  5. Gonadotropins regulate Cx43 protein expression, degradation and localization in porcine cumulus oocyte complex.

  6. Gene transfer-mediated overexpression of Cx43 increases the absolute amount of phosphorylated and intercalated disk-localized Cx43, improves conduction velocity (CV), and reduces ventricular tachycardia inducibility.

  7. These data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication.

  8. Cx43 expression and distribution are disrupted by ischemia, recovered by the well reperfused regions and further disrupted by no-reflow.

  9. Atrial connexin 43 was reduced in atrial fibrillation. Connexin 43 gene therapy prevented persistent atrial fibrillation.

  10. During ventricular fibrillation, myocardial Cx43 expression was down-regulated, which could be attenuated by administration of ZP123.

GJA1 Antigen Profile

Antigen Summary

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.

Alternative names and synonyms associated with GJA1

  • gap junction protein, alpha 1, 43kDa (gja1) antibody
  • connexin 43 (cx43) antibody
  • connexin 43 (CX43) antibody
  • CONNEXIN 43 protein (CONNEXIN 43) antibody
  • connexin 43-like (LOC100359132) antibody
  • gap junction protein, alpha 1 (Gja1) antibody
  • gap junction protein, alpha 1, 43kDa (GJA1) antibody
  • gap junction protein, alpha 3 (Gja3) antibody
  • gap junction protein, beta 1 (Gjb1) antibody
  • AI118175 antibody
  • AU042049 antibody
  • AVSD3 antibody
  • AW546267 antibody
  • Cnx32 antibody
  • Cnx43 antibody
  • Cnx46 antibody
  • connexin43 antibody
  • connexin 43 antibody
  • Cx32 antibody
  • CX43 antibody
  • cx43a1 antibody
  • Cx43alpha1 antibody
  • Cx46 antibody
  • DFNB38 antibody
  • Gja-1 antibody
  • Gja-3 antibody
  • gja1 antibody
  • gja1-A antibody
  • GJAL antibody
  • Gjb-1 antibody
  • HLHS1 antibody
  • HSS antibody
  • Npm1 antibody
  • ODDD antibody
  • zfCx43.3 antibody

Protein level used designations for GJA1

alpha 1 gap junction protein , connexin 43 , connexin-43 , etID309742.9 , gap junction alpha-1 protein , gap junction protein, alpha 1 , shf , short fin protein , sof , alpha 1 connexin , gap junction 43 kDa heart protein , gap junction membrane channel protein alpha 1 , cx43 , gap junction protein, alpha 1, 43 kD (connexin 43) , vascular smooth muscle connexin-43 , gap junction protein, alpha 1, 43kDa (connexin 43) , Connexin-43 , gap junction protein alpha 1 , gap junction protein, alpha 1, 43kDa , alpha 3 connexin , connexin-46 , gap junction alpha-3 protein , gap junction membrane channel protein alpha 3 , connexin 32 , connexin-32 , gap junction beta-1 protein , gap junction membrane channel protein beta 1

GENE ID SPECIES
394450 Xenopus (Silurana) tropicalis
30236 Danio rerio
100067229 Equus caballus
443455 Ovis aries
100359132 Oryctolagus cuniculus
14609 Mus musculus
24392 Rattus norvegicus
100379273 Cavia porcellus
281193 Bos taurus
2697 Homo sapiens
403418 Canis lupus familiaris
100518636 Sus scrofa
100008935 Oryctolagus cuniculus
373664 Xenopus laevis
395278 Gallus gallus
443233 Ovis aries
101100211 Felis catus
14611 Mus musculus
14618 Mus musculus
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