Browse our anti-RYR1 (RYR1) Antibodies

Full name:
anti-Ryanodine Receptor 1 (Skeletal) Antibodies (RYR1)
On are 29 Ryanodine Receptor 1 (Skeletal) (RYR1) Antibodies from 8 different suppliers available. Additionally we are shipping RYR1 Kits (19) and RYR1 Proteins (4) and many more products for this protein. A total of 52 RYR1 products are currently listed.
AI528790, alphaRYR, CCO, CRC, MHS, MHS1, RYDR, Ryr, RYR-1, RYR1, Ryr1l, skrr
list all antibodies Gene Name GeneID UniProt
RYR1 6261 P21817
RYR1 114207  
RYR1 20190 E9PZQ0

Show all species

Show all synonyms

Most Popular Reactivities for anti-RYR1 (RYR1) Antibodies

Select your species and application

anti-Human RYR1 Antibodies:

anti-Rat (Rattus) RYR1 Antibodies:

anti-Mouse (Murine) RYR1 Antibodies:

All available anti-RYR1 Antibodies

Go to our pre-filtered search.

Top referenced anti-RYR1 Antibodies

  1. Amphibian Monoclonal RYR1 Primary Antibody for BP, IF - ABIN152702 : Olivares, Tanksley, Airey, Beck, Ouyang, Deerinck, Ellisman, Sutko: Nonmammalian vertebrate skeletal muscles express two triad junctional foot protein isoforms. in Biophysical journal 1991 (PubMed)
    Show all 12 references for 152702

  2. Amphibian Monoclonal RYR1 Primary Antibody for ICC, FACS - ABIN266948 : Huang, Cheng, Wang, Shiao, Chen, Hung: High-fructose and high-fat feeding correspondingly lead to the development of lysoPC-associated apoptotic cardiomyopathy and adrenergic signaling-related cardiac hypertrophy. in International journal of cardiology 2016 (PubMed)

More Antibodies against RYR1 Interaction Partners

Zebrafish Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

  1. Most of the ryanodine receptor (show RYR3 Antibodies) 1b (ryr1b) mRNA in mutants carried a nonsense mutation that was generated by aberrant splicing due to a DNA insertion in an intron of the ryr1b gene, leading to a hypomorphic condition in relatively relaxed mutants.

  2. sepn1 (show SEPN1 Antibodies) and ryr1 are required for the same cellular differentiation events and are needed for normal calcium fluxes

Turkey Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

Human Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

  1. level of myotubes MTM1 (show MTM1 Antibodies) mutations do not dramatically affect calcium homeostasis and calcium release mediated through the ryanodine receptor 1, though they do affect myotube size and nuclear content..mature muscles such as those obtained from patient muscle biopsies exhibit a significant decrease in expression of the ryanodine receptor 1, a decrease in muscle-specific (show EIF3K Antibodies) microRNAs and a considerable up-regulation of HDAC4 (show HDAC4 Antibodies).

  2. Allosteric mechanism of RyR1, including a key interaction between a peripheral domain and the Ca-binding EF hand domain

  3. Data suggest that reduced SOICR (store overload-induced Ca2 (show CA2 Antibodies)+ release) threshold is a common defect of malignant hyperthermia- or central core disease-associated RyR1 mutations; carvedilol (a beta (show SUCLA2 Antibodies)-blocker), like dantrolene (a central muscle relaxant), can suppress RyR1-mediated SOICR. Here, human disease-associated point mutations were induced in recombinant rabbit RyR1 via site-directed mutagenesis.

  4. results suggest that nine RyR1 mutants associated with skeletal muscle diseases were differently regulated by Ca(2 (show SYN3 Antibodies)+) and Mg(2 (show MUC7 Antibodies)+) Four malignant hyperthermia-associated RyR1 mutations in the S2-S3 loop conferred RyR2 (show RYR2 Antibodies)-type Ca(2 (show CA2 Antibodies)+)- and Mg(2 (show MUC7 Antibodies)+)-dependent channel regulation

  5. This review summarizes the progress in the structural determination of RyR by cryoEM and, bearing in mind the leap in resolution provided by the recent implementation of direct electron detection, analyzes the first near-atomic structures of RyR.

  6. Data indicate that unlike ryanodine receptor RyRs, inositol 145-trisphosphate receptor IP3Rs are present and continually functional at early stages of cardiomyocyte differentiation.

  7. This study reveled that One novel (p.L4578V) and heterozygous missense mutations in RYR1 were identified in 7 chines patients.

  8. CaM (show CALM1 Antibodies) and S100A1 (show S100A1 Antibodies) can concurrently bind to and functionally modulate RyR1 and RyR2 (show RYR2 Antibodies), but this does not involve direct competition at the RyR CaM (show CALM1 Antibodies) binding site.

  9. the RYR1 gene has previously been implicated in the pathogenesis of malignant hyperthermia, (1) this particular variant has only been reported in one other case of malignant hyperthermia

  10. this is the first case of a patient with central core disease, carrying a RYR1 mutation in a Korean large family, who had concurrent familial hemophagocytic lymphohistiocytosis.

Cow (Bovine) Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

  1. Gain of Ca(2 (show CA2 Antibodies)+)-induced Ca(2 (show CA2 Antibodies)+) release activity of RyR1 is markedly lower than that of RyR3 (show RYR3 Antibodies) in mammalian skeletal muscle, indicating selective stabilization of RyR1

Rabbit Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

  1. Data suggest that RyR1 exhibits conformation consistent with an open-channel model sufficient for movement of Ca2 (show CA2 Antibodies)+ except for a pore constriction site; molecular dynamics simulations suggest Ca2 (show CA2 Antibodies)+ passage could be allowed by rotation of upper portion of pore-lining S6 helix away from 4-fold channel axis and twisting of Ile-4937 at channel constriction site out of the channel pore.

  2. Data suggest that reduced SOICR (store overload-induced Ca2 (show CA2 Antibodies)+ release) threshold is a common defect of malignant hyperthermia- or central core disease-associated RyR1 mutations; carvedilol (a beta (show SUCLA2 Antibodies)-blocker), like dantrolene (a central muscle relaxant), can suppress RyR1-mediated SOICR. Here, human disease-associated point mutations were induced in recombinant rabbit RyR1 via site-directed mutagenesis.

  3. RyR1-G4934A had reduced K(+) conductance and ion selectivity compared with WT. Mutations further increasing the side chain volume at these positions (G4934V and G4941I) resulted in reduced caffeine-induced Ca(2 (show CA2 Antibodies)+) release.

  4. Structural insights into the roles of divergent regions in RyR1 allosteric regulation during excitation contraction coupling.

  5. architecture of rabbit RyR1 at a resolution of 6.1 A, using electron cryomicroscopy

  6. closed-state structure of the 2.3-megadalton complex of the rabbit skeletal muscle type 1 RyR (RyR1), solved by single-particle electron cryomicroscopy at an overall resolution of 4.8 A

  7. Diminishing S-palmitoylation directly suppresses RyR1 activity as well as stimulus-coupled Ca(2 (show CA2 Antibodies)+) release through RyR1.

  8. Two regions of the ryanodine receptor (show RYR3 Antibodies) calcium channel are involved in Ca(2 (show CA2 Antibodies)+)-dependent inactivation

  9. Data indicate that S107 increased FKBP12 (show FKBP1A Antibodies) binding to RyR1 in sarcoplasmic reticulum vesicles in the presence of reduced glutathione and the NO-donor NOC12.

  10. These results suggest that the intersubunit contact region between N-terminal domains of RyR1 is a prime target for disease mutations.

Pig (Porcine) Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

  1. These results suggest that the heterogeneity of immunological and neuroendocrine response to exercise stress in pigs could be influenced by RYR1 gene mutation.

  2. Interleukin 1, IL-2 (show IL2 Antibodies), IL-10 (show IL10 Antibodies), and TNF-alpha (show TNF Antibodies) measures were positively intercorrelated in each of the three RYR1 genotype group

  3. T-tubules proximity modulates RyR cluster properties resulting in intracellular heterogeneity of diastolic spark activity.

  4. Results support the hypothesis that Ca(2 (show CA2 Antibodies))(+) binding to CaM's C-terminal acts as the switch converting CaM (show CALM Antibodies) from a RyR1 activator into a channel inhibitor.

  5. The RYR1 genotype had a significant effect on IGF-2 expression in pig longissimus dorsi muscle.

  6. Binding to RyR1 targets evokes significant changes in calmodulin (show CALM Antibodies) structure and sensitivity.

  7. Significant interactions between CAST and RYR1 genotypes indicate that the quality of meat influenced by RYR1 genotype may be modified by the simultaneous influence of genotype as regards the CAST locus

  8. Our data suggest that non-coplanar PCBs are more potent and efficacious toward (MH)RyR1 than (Wt)RyR1, and have more profound effects on its cation regulation.

  9. stimulation of the RyR1 malignant hyperthermia susceptible channel caused by affected inter-domain interaction between regions 1 and 2 is an underlying mechanism for dysfunction of Ca2 (show CA2 Antibodies)+ homoeostasis seen in the malignant hyperthermia phenotype

  10. altered luminal Ca(2 (show CA2 Antibodies)+) regulation of RyR1 represents a primary causal mechanism of malignant hyperthermia

Mouse (Murine) Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

  1. This molecular rearrangement is compatible with direct inhibition of RyR opening by junctophilin-2 (show JPH2 Antibodies) to intrinsically stabilise the Ca(2 (show CA2 Antibodies)+) signalling properties of the junction and thus the contractile function of the cell.

  2. These data demonstrate that modulating Ryrs has neuroprotective effects in nGD (show NGDN Antibodies) through mechanisms that protect the mitochondria, autophagy, Ryr expression and enhance GCase (show GBA Antibodies) activity

  3. these findings suggest an important non-contractile role of RyR1 or RYR1-mediated Ca(2 (show CA2 Antibodies)+) signaling during muscle organ development.

  4. mutating residue E4242 affects RyR1 structures critical for retrograde communication with CaV1.1 (show CACNA1S Antibodies)

  5. High-intensity interval training exercise induces a ROS (show ROS1 Antibodies)-dependent RyR1 fragmentation in muscles of recreationally active subjects, and the resulting changes in muscle fiber Ca(2 (show CA2 Antibodies)+)-handling trigger muscular adaptations

  6. The present study reveals that the C-terminal of the beta1a subunit changes conformation in the presence of RyR1 consistent with an interaction between the C-terminal of beta1a and RyR1 in resting myotubes.

  7. Ryanodine receptor (show RYR3 Antibodies) sensitization results in abnormal calcium signaling in airway smooth muscle cells.

  8. major finding from this study is the novel region- and cell-specific relationship between the localization of the plasma membrane Kv2.1 (show KCNB1 Antibodies) channel and intracellular RyR Ca2 (show CA2 Antibodies)+ release channels

  9. RyR1 is required for proper release of transmitter at the neuromuscular junction, and postsynaptic RyR1 is required for the size and distribution of acetylcholine receptor (show CHRNB1 Antibodies) clusters.

  10. Spindle abnormalities precede those in extrafusal fibers, indicating that they are a primary pathological feature in this murine Ryr1-related core myopathy. [review]

RYR1 Antigen Profile

Antigen Summary

This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described.

Alternative names and synonyms associated with RYR1

  • ryanodine receptor 1 (skeletal) (RYR1) antibody
  • ryanodine receptor 1a (skeletal) (ryr1a) antibody
  • ryanodine receptor 1 (skeletal) (Ryr1) antibody
  • ryanodine receptor 1, skeletal muscle (Ryr1) antibody
  • AI528790 antibody
  • alphaRYR antibody
  • CCO antibody
  • CRC antibody
  • MHS antibody
  • MHS1 antibody
  • RYDR antibody
  • Ryr antibody
  • RYR-1 antibody
  • RYR1 antibody
  • Ryr1l antibody
  • skrr antibody

Protein level used designations for RYR1

ryanodine receptor 1 (skeletal) , ryanodine receptor type 1 , ryanodine receptor 1a (slow muscle) , ryanodine receptor alpha isoform , central core disease of muscle , ryanodine receptor 1 , sarcoplasmic reticulum calcium release channel , skeletal muscle calcium release channel , skeletal muscle ryanodine receptor , type 1-like ryanodine receptor , skeletal muscle-type ryanodine receptor , type 1 ryanodine receptor , ryanodine receptor 1, skeletal muscle , ryanodine receptor 1-like, skeletal muscle , RYR-1 , calcium release channel , halothane , porcine stress syndrome

396112 Gallus gallus
719601 Macaca mulatta
798565 Danio rerio
100008574 Meleagris gallopavo
100034090 Equus caballus
100612063 Pan troglodytes
6261 Homo sapiens
606491 Canis lupus familiaris
100139857 Bos taurus
100009540 Oryctolagus cuniculus
114207 Rattus norvegicus
396718 Sus scrofa
20190 Mus musculus
Selected quality suppliers for anti-RYR1 (RYR1) Antibodies
Did you look for something else?