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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 ELISA Kits (ABCC8)
On www.antibodies-online.com are 5 ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) ELISA Kits from 4 different suppliers available. Additionally we are shipping ABCC8 Antibodies (87) and ABCC8 Proteins (8) and many more products for this protein. A total of 104 ABCC8 products are currently listed.
Synonyms:
ABC36, D930031B21Rik, HHF1, HI, HRINS, MRP8, PHHI, Sur, Sur1, SUR1delta2, TNDM2
list all ELISA KIts Gene Name GeneID UniProt
ABCC8 6833 Q09428
Mouse ABCC8 ABCC8 20927  
Rat ABCC8 ABCC8 25559 Q09429

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Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) interaction partners

  1. Mutation in ABCC8 gene is associated with congenital hyperinsulinism.

  2. ABCC8 mutation causing loss of function of beta-cell KATP channels lead to congenital hyperinsulinism, higher basal [Ca(2+)] i and insulin secretion, increased insulin secretion in response to amino acids but not to glucose, increased basal rate of oxygen consumption and mitochondrial mass, increased rates of glycolysis, increased serine/glycine and glutamine biosynthesis, and low gamma-aminobutyric acid (GABA) levels.

  3. Hyperinsulinism-causing mutations cause multiple molecular defects in SUR1 nucleotide-binding domains.

  4. Genes ABCC7 (show CFTR ELISA Kits), A3, A8, A12 (show UGT1A9 ELISA Kits), and C8 prevailed among the most upregulated or downregulated ones. In conclusion, the results supported our theory about general adenosine triphosphate-binding cassette gene expression profiles and their importance for cancer on clinical as well as research levels.

  5. Cross-linking experiments showed that KATP channel inhibitors promoted interactions between the N terminus of Kir6.2 and SUR1, whereas channel openers did not, suggesting the inhibitors enhance intersubunit interactions to overcome channel biogenesis and trafficking defects.

  6. Mutations of the ABCC8 gene is associated with congenital hyperinsulinism.

  7. ABCC8 mutation is associated with neonatal diabetes mellitus and iDEND syndrome.

  8. The most frequently seen mutations in Turkish patients with congenital hyperinsulinism (CHI) were ATP binding cassette subfamily C (show CYP ELISA Kits) member 8 (ABCC8) gene, followed by 3-hydroxyacyl CoA dehydrogenase (HADH (show HADH ELISA Kits)) and kcnj11 (show KCNJ11 ELISA Kits) channel (KCNJ11 (show KCNJ11 ELISA Kits)) genes.

  9. Mutations in the ABCC8 gene were the most common cause of congenital hyperinsulinism in our cohort.

  10. ABCC8 mutation is associated with persistently elevated insulin (show INS ELISA Kits) concentrations.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) interaction partners

  1. Despite its importance in central nervous system (CNS) injuries, sulfonylurea receptor 1 (SUR1) upregulation appears to play no part in rodent anterior ischemic optic neuropathy (rAION) injury.

  2. study provides evidence for a role of Abcc8(ATP-binding cassette sub-family C) in early-phase glucose-mediated insulin (show INS ELISA Kits) secretion and validates this gene as a contributor to beta-cell dysfunction in type 2 diabetes

  3. We conclude that the gradual development of glucose intolerance in patients with the SUR1-E1506K mutation might, as in the mouse model, result from impaired insulin (show INS ELISA Kits) secretion due a failure of insulin (show INS ELISA Kits) content to increase with age.

  4. The results confirm that Kir6.2 (show KCNJ11 ELISA Kits) contributes to APD shortening in both atria and ventricle during metabolic stress, and that SUR1 is required for atrial APD shortening while SUR2A (show ABCC9 ELISA Kits) is required for ventricular APD shortening.

  5. EPAC (show RAPGEF3 ELISA Kits) interaction with SUR1 controls seizure susceptibility and possibly acts via regulation of glutamate (show GRIN1 ELISA Kits) release.

  6. the role of CpG methylation in regulating SUR1 and SUR2 (show ABCC9 ELISA Kits) expression

  7. SUR1 controls K(ATP) channel activity but not TRPM4 (show TRPM4 ELISA Kits) channels.

  8. Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC (show ABCB6 ELISA Kits)) transporters ABCB6 (show ABCB6 ELISA Kits) and sulfonylurea receptor 1 (SUR1)/ABCC8.

  9. ATP regulates pancreatic beta-cell K(ATP) channel activity, not only by its direct actions on Kir6.2 pore subunit, but also via ATP modulation of Syn-1A binding to SUR1.

  10. Diazoxide does not open the ventricular sarcolemmal adenosine triphosphate-sensitive potassium channel but provides volume homeostasis via an SUR1-dependent pathway in mouse ventricular myocytes.

Pig (Porcine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) interaction partners

  1. islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1), inward rectifying potassium channel (show KCNAB2 ELISA Kits) (Kir6.2 (show KCNJ11 ELISA Kits), associated with Sur1), glucagon-like peptide 1 receptor (GLP1R (show GLP1R ELISA Kits)), and adrenergic receptor alpha 2A (show ADRA2A ELISA Kits) (ADRalpha2A)

ABCC8 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed\; however, the transcript variants have not been fully described.

Alternative names and synonyms associated with ABCC8

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (ABCC8) Elisa Kit
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (Abcc8) Elisa Kit
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 8 (Abcc8) Elisa Kit
  • ABC36 Elisa Kit
  • D930031B21Rik Elisa Kit
  • HHF1 Elisa Kit
  • HI Elisa Kit
  • HRINS Elisa Kit
  • MRP8 Elisa Kit
  • PHHI Elisa Kit
  • Sur Elisa Kit
  • Sur1 Elisa Kit
  • SUR1delta2 Elisa Kit
  • TNDM2 Elisa Kit

Protein level used designations for ABCC8

ATP-binding cassette, sub-family C (CFTR/MRP), member 8 , ATP-binding cassette, sub-family C, member 8 , ATP-binding cassette sub-family C member 8 , ATP-binding cassette transporter sub-family C member 8 , sulfonylurea receptor (hyperinsulinemia) , sulfonylurea receptor 1 , sulfonylurea receptor , sulphonylurea receptor 1

GENE ID SPECIES
423072 Gallus gallus
451056 Pan troglodytes
654490 Macaca mulatta
6833 Homo sapiens
20927 Mus musculus
485402 Canis lupus familiaris
538996 Bos taurus
100158245 Sus scrofa
100722700 Cavia porcellus
25559 Rattus norvegicus
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