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Human MUC1 ELISA Kit for Sandwich ELISA - ABIN414976
Maker, Katabi, Gonen, DeMatteo, DAngelica, Fong, Jarnagin, Brennan, Allen: Pancreatic cyst fluid and serum mucin levels predict dysplasia in intraductal papillary mucinous neoplasms of the pancreas. in Annals of surgical oncology 2011
Show all 5 Pubmed References
Results that overexpression and aberrant glycosylation of MUC1 on tumor cells influences many critical steps in tumor initiation, progression, and metastasis as well as in tumor immunosurveillance. This hypoglycosylated tumor form of MUC1 is also overexpressed during chronic inflammation and in premalignant lesions that progress to tumors. [review]
MUC1 role in pulmonary fibrosis
We have identified novel MUC1 class I peptides that bind to HLA-A*0201 molecules with significantly higher affinity and function than the native MUC1 peptides. These peptides elicited CTLs from normal donors, as well as breast cancer patients, which were highly effective in killing MUC1-expressing MCF-7 breast cancer cells.
Low MUC1 expression is associated with tongue squamous cell carcinoma.
Pseudomonas aeruginosa - stimulated MUC1 expression in THP-1 (show GLI2 ELISA Kits) macrophages is regulated mainly through the TLR4 (show TLR4 ELISA Kits)-p38 (show CRK ELISA Kits) signaling pathway.
A previously unrecognized central role for MUC1-C in integrating PD-L1 (show CD274 ELISA Kits) activation with suppression of immune effectors and poor clinical outcome in non-small-cell lung cancer.
Studied and analyzed MUC1 in specimens from patients with cholangiocarcinoma and pancreatic ductal adenocarcinoma. Using lectin microarray analysis, analyzed and found different glycoforms of MUC1 could distinguish between different cancers and degree of malignancy.
These findings uncover a previously unrecognized role for MUC1-C in driving BMI1 (show BMI1 ELISA Kits) expression and in directly interacting with this stem cell factor (show KITLG ELISA Kits), linking MUC1-C with function of the PRC1 (show PRC1 ELISA Kits) in epigenetic gene silencing.
our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1 (show NELL1 ELISA Kits)-dependent VEGFR (show KDR ELISA Kits) signaling in PDA cells.
Results suggest that MUC1 serves as a metabolic regulator in triple-negative breast cancer, facilitating the metabolic reprogramming of glutamine utilization that influences triple-negative breast cancer tumor growth.
The results indicate that Muc1 gene is significantly associated with litter size in pigs.
The epiblast expressed epithelial markers, MUC1 and E-CADHERIN (show CDH1 ELISA Kits), and the pluripotency markers, DNMT3B (show DNMT3B ELISA Kits) and CRIPTO (show TDGF1 ELISA Kits).
Endometrial expressions of MUC1 and cytokine genes differed among normal, fertile versus diseased, and subfertile dairy cows.
Bovine Muc1 prevents binding of bacteria to human intestinal cells and may have a role in preventing the binding of common enteropathogenic bacteria to human intestinal epithelial surfaces.
concluded that bovine Muc1 protein is probably an inducible innate immune effector and an important component of the first line of defense against bacterial invasion of epithelial surfaces
Muc1 has anti-fibrotic properties in the mouse lung.
our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1 (show NRP1 ELISA Kits)-dependent VEGFR (show KDR ELISA Kits) signaling in PDA cells.
Low expression of MUC1 is associated with lung carcinogenesis.
Using an extensive collection of novel murine cell lines we have identified distinct roles for Kras and Pten on MUC1 and EMT (show ITK ELISA Kits) in vivo and in vitro. The data has implications for future design of combination therapies targeting Kras mutations, Pten deletions and MUC1 vaccines.
Gp91phox (show CYBB ELISA Kits) NADPH oxidase (show NOX1 ELISA Kits) modulates litter size by up-regulating mucin1 expression in the uterus of mice.
In summary, we have demonstrated that MUC1 on immune cells is a novel regulator of the NLRP3 (show NLRP3 ELISA Kits) inflammasome, and propose this is mediated by an interaction with signalling components at the cytoplasmic domains of TLRs that involves inhibition of IRAK4 (show IRAK4 ELISA Kits) activation.
MUC1 regulates IL-1beta (show IL1B ELISA Kits) secretion induced by the NLRP3 (show NLRP3 ELISA Kits)-activating bacteria Haemophilus influenzae but not bacteria that activate other inflammasomes.
Muc1 protection during acute kidney injury proceeds by enhancing both the HIF-1 (show HIF1A ELISA Kits) and beta-catenin (show CTNNB1 ELISA Kits) protective pathways.
MAMs MUC1 and MUC16 (show MUC16 ELISA Kits) contribute to the maintenance of immune homeostasis at the ocular surface by limiting TLR-mediated innate immune responses.
the present study provides evidence that Muc1 is a direct target of let-7a and let-7b in mouse uteri during embryo implantation.
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
, H23 antigen
, breast carcinoma-associated antigen DF3
, cancer antigen 15-3
, carcinoma-associated mucin
, krebs von den Lungen-6
, mucin 1, transmembrane
, peanut-reactive urinary mucin
, polymorphic epithelial mucin
, tumor associated epithelial mucin
, tumor-associated epithelial membrane antigen
, tumor-associated mucin
, endometrial mucin-1
, epithelial mucin